7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, belongs to triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 3,5-Dibromo-1H-1,2,4-triazole
In a 500 mL round bottomed flask, 3,5-dibromo-1H-1,2,4-triazole (Int-1, 3.00 g, 13.2 mmol) was dissolved in 1,2-dichloroethane (100 mL), and cyclopropylboronic acid (2.84 g, 33.1 mmol), sodium carbonate (3.50 g, 33.1 mmol), copper(II) acetate (2.94 g, 15.9 mmol) and 2,2′- bipyridine (2.50 g, 15.9 mmol) were added. The reaction mixture was stirred for 3 h at 75 C. After that, it was diluted with dichloromethane (100 mL) and washed with saturated aqueous solution of ammonium chloride (100 mL) and brine (100 mL), dried (sodium sulfate) and concentrated in vacuo. The crude product was purified by column chromatography (silica gel, 80 g, eluting with dichloromethane / methanol, gradient 100:0 to 95:5 v/v) to afford the title compound as colorless oil (660 mg, 13%). HPLC (method LCMS_fastgradient) tR = 1.00 min. 1H NMR (CDCl3, 300 MHz): delta 1.12- 1.31 (m, 4 H), 3.45-3.54 (m, 1 H). MS (ES+) mJz 265.8, 267.7, 269.8 [M+H, 2 Br isotopes] .
The synthetic route of 7411-23-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
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