New discoveries in chemical research and development in 2021. The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 4928-87-4, name is 1,2,4-Triazole-3-carboxylic acid belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 1,2,4-Triazole-3-carboxylic acid
A mixture of l-(7-Amino-5-(-8-azabicyclo[3.2.1]octan-3-yl)-3-(6-phenylpyridin-3- yl)pyrazolo[l,5-a]pyrimidin-6-yl)ethanone (131.4mg, 0.30 mmol), N2H4.H2O (150 ul, 3.0 mmol) in NMP (10 ml) was heated first at 100C for 30 min and then at 200C for 60 min under microwave condition. The mixture was put on rotovap and concentrated at 60C for 2h to remove excess N2H4.H20. lH-l,2,4-triazole-3-carboxylic acid (101.7 mg, 0.90 mmol), EDC (229 mg, 1.20 mmol), HOBt (121.5 mg, 0.90 mmol) and DIEA (521.6 uL, 3.0 mmol) were then added and the mixture was stirred at room temperature for lh. Purification with prep-LC pro ided (( 1 R,3 s,5 S)-3 -(3 -methyl-6-(6-phenylpyridin-3 -yl)- 1 H-dipyrazolo [1,5- a:4′,3′-e]pyrimidin-4-yl)-8-azabicyclo[3.2.1]octan-8-yl)(4H-l,2,4-triazol-3-yl)methanone.
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Reference:
Patent; MERCK SHARP & DOHME CORP.; MENG, Zhaoyang; PATEL, Mehul, F.; SIDDIQUI, M. Arshad; REDDY, Panduranga Adulla, P.; NAN, Yang; WO2013/16164; (2013); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics