Synthetic Route of 3641-13-2,Some common heterocyclic compound, 3641-13-2, name is 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, molecular formula is C3H4N4O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Add 90 mL of anhydrous methanol to a 250 mL three-necked flask. Take 12.8 g (10 mmol) of 3-amino-1H-1,2,4-triazole-5carboxylic acid, Stir it in anhydrous methanol. Take 6mL of 50% fuming H2SO4 and slowly add it to the reaction solution. The temperature was raised to 85 C and refluxed for 12 h. Naturally cooled, rotary distillation to remove some methanol, Precipitation gave precipitation of methyl 3-amino-1H-1,2,4-triazole-5-carboxylate sulfate. Add 20 mL of distilled water to the precipitate, and adjust the pH to 5-6 with NaOH (5 mol¡¤L-1). Filtered to give a white precipitate. Wash 2-3 times with absolute ethanol, Drying gave methyl 3-amino-1H-1,2,4-triazole-5-carboxylate (yield: 73%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5-Amino-4H-1,2,4-triazole-3-carboxylic acid, its application will become more common.
Reference:
Patent; China Engineering Physics Institute Chemical Materials Institute; Zhang Qi; Wang Tingwei; Chen Dong; Li Hongzhen; (10 pag.)CN109096215; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics