Application of 41253-21-8, A common heterocyclic compound, 41253-21-8, name is Sodium 1,2,4-triazol-1-ide, molecular formula is C2H2N3Na, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
(i) Preparation of crude anastrozole Into a IL, three-necked RB flask was charged 54g of sodium triazole monohydrate and 500ml of dry DMF under nitrogen atmosphere. The reaction mass was cooled to 25 C. (2,2′-[5-Bromomethyl)-l,3-phenylene]di(2-methylpropio-nitrile was added to the reaction mass over a period of 2hr. The reaction mass was maintained at this temperature until the completion of reaction. The reaction mass was transferred into 3 L flask containing 1.6L of water and stirred for 30min. Reaction mass was extracted with toluene (2 x 300ml and 1 x 100ml). Toluene layers were combined and washed with water (2 x 200ml). Toluene layer was treated with activated carbon (5g) and filtered. Toluene was distilled off from the filtrate under vacuum to get 98g of crude anastrozole.
The synthetic route of 41253-21-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NATCO PHARMA LIMITED; PULLA REDDY, Muddasani; SAMBASIVA RAO, Talasila; VENKAIAH CHOWDARY, Nannapaneni; WO2007/39919; (2007); A1;,
1,2,3-Triazole – Wikipedia,
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