In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 626248-56-4, name is 3-(2H-1,2,3-Triazol-2-yl)aniline belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. Recommanded Product: 626248-56-4
Example No. 262Preparation of N- (3 – (2H-1, 2 , 3 -triazol-2 -yl) phenyl) -5-(thiophen-2-yl) -IH-pyrazolo [4 , 3-d] pyrimidin-7-amine7-chloro-2- (4-methoxybenzyl) -5- (thiophen-2-yl) -2H- pyrazolo [4 , 3 -d] pyrimidine (0.16 mmol) and 3 – (2H- 1 , 2 , 3 -triazol- 2-yl)aniline (0.3 mmol 2 eq.,) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 360.1031 g/molHPLC-MS: analytical method Drt : 6.78 min – found mass: 361 (m/z+H)
The synthetic route of 626248-56-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; TRAUBE, Nadine; WO2012/143144; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics