Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 118863-62-0, name is 3-(4-Bromophenyl)-1H-[1,2,4]triazole, A new synthetic method of this compound is introduced below., Formula: C8H6BrN3
Example 243 (S)-2-((1-(4-(1H-1,2,4-Triazol-3-yl)phenyl)-7,8,9,10-tetrahydro-6-oxa-2,10a-diazacycloocta[cd]inden-4-yl)oxy)propanamide 243 243 was prepared using commercially available 3-(4-bromophenyl)-1H-1,2,4-triazole and following procedures analogous to those of Example 242. LCMS (ESI): RT (min)=1.02, [M+H]+=419, method=F; 1H NMR (300 MHz, DMSO-d6) delta 12.28 (br, 1H), 8.53 (s, 1H), 8.20 (d, J=8.4 Hz, 2H), 7.82 (d, J=8.4 Hz, 2H), 7.55 (s, 1H), 7.25 (s, 1H), 6.94 (d, J=2.1 Hz, 1H), 6.62 (d, J=2.1 Hz, 1H), 4.67-4.60 (m, 1H), 4.44-4.40 (m, 2H), 4.27-4.24 (m, 2H), 2.20-2.00 (m, 2H), 1.80-1.55 (m, 2H), 1.45 (d, J=6.6 Hz, 3H).
The synthetic route of 118863-62-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Genentech, Inc.; Braun, Marie-Gabrielle; Garland, Keira; Hanan, Emily; Purkey, Hans; Staben, Steven T.; Heald, Robert Andrew; Knight, Jamie; Macleod, Calum; Lu, Aijun; Wu, Guosheng; Yeap, Siew Kuen; (183 pag.)US2018/65983; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics