The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 6-Methylnicotinic acid(SMILESS: O=C(O)C1=CN=C(C)C=C1,cas:3222-47-7) is researched.HPLC of Formula: 305798-02-1. The article 《Catalytic enantioselective pyridine N-oxidation》 in relation to this compound, is published in ChemRxiv. Let’s take a look at the latest research on this compound (cas:3222-47-7).
The catalytic, enantioselective N-oxidation of substituted pyridines is described. The approach is predicated on a biomol.-inspired catalytic cycle wherein high levels of asym. induction are provided by aspartic acid-containing peptides as the aspartyl side chain shuttles between free acid and peracid forms. Desymmetrizations of bis(pyridine) substrates bearing a remote pro-stereogenic center are demonstrated, presenting a new entry into chiral pyridine frameworks in a heterocycle-rich mol. environment. Representative functionalizations of the enantioenriched pyridine N-oxides further document the utility of this approach. Demonstration of the asym. N-oxidation in two venerable drug-like scaffolds, Loratadine and Varenicline, show the likely generality of the method for highly variable and distinct chiral environments, while also revealing that the approach is applicable to both pyridines and 1,4-pyrazines.
In some applications, this compound(3222-47-7)Electric Literature of C7H7NO2 is unique.If you want to know more details about this compound, you can contact with the author or consult more relevant literature.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics