Synthesis of vaniprevir (MK-7009): Lactamization to prepare a 20-membered macrocycle was written by Song, Zhiguo J.;Tellers, David M.;Journet, Michel;Kuethe, Jeffrey T.;Lieberman, David;Humphrey, Guy;Zhang, Fei;Peng, Zhihui;Waters, Marjorie S.;Zewge, Daniel;Nolting, Andrew;Zhao, Dalian;Reamer, Robert A.;Dormer, Peter G.;Belyk, Kevin M.;Davies, Ian W.;Devine, Paul N.;Tschaen, David M.. And the article was included in Journal of Organic Chemistry in 2011.Formula: C17H27F6N7OP2 The following contents are mentioned in the article:
Development of a practical synthesis of MK-7009 I, a 20-membered macrocycle, is described. A variety of ring-closing strategies were evaluated, including ring-closing metathesis, intermol. palladium-catalyzed cross-couplings, and macrolactamization. Ring closure via macrolactamization was found to give the highest yields under relatively high reaction concentrations Optimization of the ring formation step and the synthesis of key intermediates en route to MK-7009 are reported. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Formula: C17H27F6N7OP2).
((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. Many triazoles have antifungal effects: the triazole antifungal drugs include fluconazole, isavuconazole, itraconazole, voriconazole, pramiconazole, ravuconazole, and posaconazole and triazole plant-protection fungicides include epoxiconazole, triadimenol, myclobutanil, propiconazole, prothioconazole, metconazole, cyproconazole, tebuconazole, flusilazole and paclobutrazol.Formula: C17H27F6N7OP2
Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics