These common heterocyclic compound, 1001401-62-2, name is 2-(2H-1,2,3-Triazol-2-yl)benzoic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. SDS of cas: 1001401-62-2
Step 2) Synthesis of 2- (2H-1, 2, 3-triazol-2-yl) benzoyl chloride To a solution of 2- (2H-1, 2, 3-triazol-2-yl) benzoic acid (0.37 g, 1.96 mmol) in anhydrous DCM (20 mL) were added slowly sulfoxide chloride (6 mL, 82.7 mmol) and pyridine (0.04 mL, 0.5 mmol) . The reaction was heated to reflux and stirred for 3 hours, and then cooled and the solvent was removed in vacuo to give a product, which was used directly in the next step.
The synthetic route of 2-(2H-1,2,3-Triazol-2-yl)benzoic acid has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SUNSHINE LAKE PHARMA CO., LTD.; ZHANG, Yingjun; JIN, Chuanfei; ZHANG, Ji; (90 pag.)WO2017/88759; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics