Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1186050-58-7, name is 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid, A new synthetic method of this compound is introduced below., name: 2-Fluoro-6-(2H-1,2,3-triazol-2-yl)benzoic acid
Method B:Step A: A one-piece EasyMax reactor was equipped with a mechanical stirred, a temperature probe, a reflux condenser and an NaOH scrubber. To the reactor was added 2-fluoro-6-triazol-2-yl benzoic acid (15.01 g, 72.5 mmol) and toluene (150.0 g), N, N dimethylformamide (0.06 g, 0.26 mmol) was then added, the reaction was held at 20 C prior to the addition of thionyl chloride (1 1 .31 g, 94.1 mmol) via syringe pump. The reaction mixture was then heated to 50 C over 15 minutes and then was stirred at that temperature for 1 .5 hours. The mixture was then heated to 55 C and 20.4 g of solvent were distilled in vacuo to give 139.4 g of acid chloride solution which was used as is in Step C below.
The synthetic route of 1186050-58-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; JANSSEN PHARMACEUTICA NV; LETAVIC, Michael; RUDOLPH, Dale, A.; SAVALL, Brad, M.; SHIREMAN, Brock, T.; SWANSON, Devin; WO2012/145581; (2012); A1;,
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