Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1455-77-2, name is 3,5-Diamino-1,2,4-triazole, A new synthetic method of this compound is introduced below., Computed Properties of C2H5N5
A solution of 3-(dimethylamino)-1-phenylpropan-1-one hydrochloride 9 (9.36 mmol) and diaminotriazole 10 (9.36 mmol) in 20 mL of acetic acid was heated to reflux for 6 h. The reaction mixture was cooled and the solvent evaporated in vacuo to furnish a mixture of desired product 12 (minor) and 5-phenyl-6,7-dihydro-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine (major). The crude mixture was taken to the next step without any further purification and it was treated with N-bromosuccinimide (14.03 mmol) in ethanol (20 mL) under reflux for 5 h to promote the oxidation of the dihydrotriazolopyrimidine. The reaction mixture was cooled, and the solvent was evaporated in vacuo to yield a pale-yellow solid. The crude compound was purified by flash chromatography on silica gel using as eluent a gradient of EtOAc (0-50percent) to produce the desired compound 12 as white solid (adapted from 2). Yield: 29percent (0.57 g). 1H NMR (600 MHz, DMSO-d6) delta 9.07 (d, J = 6.9 Hz, 1H), 8.21 ? 8.19 (m, 2H), 7.72 (d, J = 6.9 Hz, 1H), 7.56 (s, 3H). HRMS-ESI (+) m/z calculated for C11H10N5, 212.0936 [M+H]+; found: 212.0941
The synthetic route of 1455-77-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Ribeiro, Carlos J.A.; Kankanala, Jayakanth; Xie, Jiashu; Williams, Jessica; Aihara, Hideki; Wang, Zhengqiang; Bioorganic and Medicinal Chemistry Letters; vol. 29; 2; (2019); p. 257 – 261;,
1,2,3-Triazole – Wikipedia,
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