Sources of common compounds: 1H-1,2,3-Triazole

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.

288-36-8, A common compound: 288-36-8, name is 1H-1,2,3-Triazole, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

To a soution of 23-dichoro-5-nitropyridine (lOg, 5.18 mmo) and K2003 (1.43 g, 10.4 mmo) in THF (5 m) was added 2H-1,2.3-triazoe (0.360 m, 6.22 mrnoD. The reaction mixture was stirred for overnight at RT. Since the reaction was uncompete, additiona 2H-1,2,3-triazoe (0.300 mL 5.18 mmo) was added and reaction mixture was stirred over2 days at RT. Water was added and the mixture was extracted with AcOEt. The organic ayer was washed with brine, dried over Na2SO4, fi[tered and concentrated under vacuum. The residue taken-up in DCM, the soHd was fHtered off and the fi[trate was evaporated. The residue was purified by flash cournn chromatography on si?ica g& (cycohexane/AcOEt: 1/0 to 7/3) to afford 3-choro-5-nitro-2-(2H-1 2,3-triazo-2- y)pyridine. Rt = 0.75 mm (UPLC Method BI), 1H NMR (400 MHz, DMSO-d6) O ppm:939 (d, IH), 9.15 (d, IH), 833 (s, 2H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1H-1,2,3-Triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; PISSOT SOLDERMANN, Carole; QUANCARD, Jean; SCHLAPBACH, Achim; SIMIC, Oliver; TINTELNOT-BLOMLEY, Marina; ZOLLER, Thomas; (161 pag.)WO2015/181747; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics