Application of 23579-79-5, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 23579-79-5, name is 3,5-Dibromo-1-methyl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.
To a stirred solution of 3,5-dibromo-l-methyl-lH-l,2,4-triazole (CAS 23579-79-5; 1 g, 4.15 mmol) at r.t. in DMF (15 ml) under an argon atmosphere was added pyrrolidine (310 mg, 360 mu, 4.36 mmol). The mixture was heated to 125C for 1 day. The mixture was cooled to r.t., diluted with EtOAc and washed with H20. The aqueous phase was back extracted with EtOAc. The combined organics were washed with H20 and brine, dried over MgS04, filtered and con- centrated. The crude product was purified by silica gel chromatography using a CH2Cl2/MeOH 9: 1 as eluent, providing the title compound (451 mg, 44%) as brown oil. MS: M = 231.1 (M+H)+
The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1-methyl-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; FLOHR, Alexander; GROEBKE ZBINDEN, Katrin; LERNER, Christian; WO2014/72261; (2014); A1;,
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