Reference of 27808-16-8, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 27808-16-8 as follows.
To a mixture of 5-bromo-2-chloro-3-(difluoromethyl)quinoline (115 mg, 0.385 mmol) and 4-methyl-1H-1,2,3-triazole (99 mg, 1.2 mmol) in DMF (3 mL) was added K2CO3 (164 mg, 1.19 mmol). The mixture was heated at 80 C. overnight, then poured into water (30 mL) and extracted with Et2O (30 mL*3). The combined organic layers were dried over Na2SO4, filtered and concentrated under reduced pressure. The residue was purified by SiO2 gel chromatography (60% to 90% EtOAc in petroleum ether) to give the title compound as a yellow solid (109 mg, 84%). MS (ES+): C13H9BrF2N4 requires: 338, found: 339 [M+H]+.
According to the analysis of related databases, 27808-16-8, the application of this compound in the production field has become more and more popular.
Reference:
Patent; Board of Regents, The University of Texas System; LE, Kang; SOTH, Michael J.; LIU, Gang; JONES, Philip; CROSS, Jason Bryant; MCAFOOS, Timothy Joseph; CARROLL, Christopher L.; LEWIS, Richard T.; (199 pag.)US2019/308978; (2019); A1;,
1,2,3-Triazole – Wikipedia,
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