16227-12-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 16227-12-6, name is 4-Phenyl-4H-1,2,4-triazole, A new synthetic method of this compound is introduced below.
EXAMPLE 129 4-phenyl-1-(hex-1-yl)triazolium bromide 0.15 g (0.001 mol) 4-phenyltriazole 1 and 0.42 ml (0.495 g, 0.003 mol) 1-bromohexane 2 are combined in a pressure tube. The mixture is stirred for 12 h at 110 C. Subsequently, it is cooled down to room temperature. The precipitated solid is taken up in a 1:1 mixture of THF and petroleum ether, is filtered off, and washed with diethylether. M 310.23 C14H20N3Br Yield: 0.254 g (82%) 1H-NMR DM-231 (300 MHz/DMSO): (ppm)=0.89 (t, 3H, 12-H); 1.33 (m, 6H, 9/10/11H): 1.96 (q, 2H, 8-H); 4.45 (t, 2H, 7-H); 7.69 (m, 3H, 5/5’/6H); 7.86 (d, 2H, 4/4′-H); 9.81 (s, 1H, 2-H); 10.88 (s, 1H, 1-H) 13C-NMR DM-231 (75.475 MHz/DMSO):
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; TECHNISCHE UNIVERSITAET DRESDEN; US2011/105761; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics