Reference of 6523-49-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 6523-49-5 as follows.
Example 3; N*4*,N*4’*-Bis-(4-[l,2,4]triazol-l-yI-phenyl)-[6,6′]biquinazoIinyl-4,4′-diamine; N’-[3,3′-Dicyano-4′-(dimethylammo-methyleneamino)-biphenyl-4-yl]-N3N-dimethyl- formamidine (lOOmg, 0.29mmol) and 4-(lH-l,2,4-triazol-l-yl)aniline (93mg, 0.58mmol) were combined in acetic acid (50OuL) and heated to 125 for 90minutes. The solid was isolated by filtration and washed with water, then slurried with aqueous potassium carbonate. The solid was filtered and washed with water before drying in vacuo to give the title compound as a cream solid( 90mg, 54%)1H NMR (DMSO) delta 11.95 (IH, s), 10.2 (IH, s), 9.28 ( IH, s), 9.03 ( IH, s) 8.69 (IH, S), 8.47 (IH, d) 8.25 (IH, s), 7.9-8.1 ( 4H, m) LC-MS rt 2.43 m/z 573 ES- 575 ES+ EPO
According to the analysis of related databases, 6523-49-5, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2006/79833; (2006); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics