Adding a certain compound to certain chemical reactions, such as: 6523-49-5, name is 4-(1,2,4-Triazol-1-yl)aniline, belongs to triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6523-49-5, Safety of 4-(1,2,4-Triazol-1-yl)aniline
The product from step 1 (850 mg) was heated in DMF-DMA (1.32 ml) for 1.5 h. On cooling the mixture was diluted with ether, filtered and washed with further ether to give the formamidine as a grey solid (564 mg). A portion of this material (54 mg) was treated with 4-triazolyl-aniline (35 mg) in AcOH (1.5 ml) at 100 for 2 h, cooled and diluted with water (25 ml). Basified with NaOH, filtered and the solid dried to give the title compound (54.4 mg, 70 %). 1H NMR delta 10.0 (IH, s), 9.18 (IH, s) 8.67 (IH, s), 8.51 (IH, s), 8.14 (IH, s), 8.0(3H, m), 7.8 (2H, d), 7.72 (IH, d, J 8.85Hz), 7.48 (IH, s), 7.15 (IH, s), 2.2 (3H, s); LC-MS rt 2.72 m/z 385 ES+.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 4-(1,2,4-Triazol-1-yl)aniline, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ARROW THERAPEUTICS LIMITED; WO2007/80401; (2007); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics