New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products via catalytic C–H bond functionalisation has revolutionised modern synthetic chemistry. 6818-99-1, name is 3-Chloro-1,2,4-triazole belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 6818-99-1
2- [6-Chloro-3- (ethanesulfonyl) pyridin-2-yl] -3-methyl-6- (pentafluoroethyl)-3H-imidazo [4,5-b] 300mg, sodium hydride (60 %, in a mixture of oil) 45mg and DMF 1.3mL, was added under ice-cooling 3-chloro-1H-1,2,4-triazole 116mg. The reaction mixture was stirred under ice cooling for 20 hours, water was added to the reaction mixture, followed by extraction with ethyl acetate. The resulting organic layer was dried over anhydrous sodium sulfate, and then dried under reduced pressure. The resulting residue was subjected to silica gel chromatography, the compounds of the present invention beta33 referred to below was obtained 240mg.
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Reference:
Patent; SUMITOMO CHEMICAL COMPANY LIMITED; NAKAJIMA, YUJI; OKAWARA, YUICHI; (263 pag.)JP2016/102104; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics