7170-01-6, These common heterocyclic compound, 7170-01-6, name is 3-Methyl-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Compound 10 (62.0 g, 115 mmol), Pd2 (dba) 3 (21.0 g, 22.9 mmol), dppf (14.0 g,25.2mmol), Cs2CO3 (112g, 344mmol),3-Methyl-1H-1,2,4-triazole (21.0 g, 252 mmol) was mixed in toluene (600 mL), stirred and warmed to reflux for 4 hr.After cooling, tap water (600 mL) was added and liquid separation was carried out. The organic phase is dried,Crystallization from petroleum ether gave compound 11 (41.9 g, 77.5%).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7170-01-6.
Reference:
Patent; Liu Fengjuan; (8 pag.)CN108623631; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics