Application of 7411-23-6, New Advances in Chemical Research in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis. 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, below Introduce a new synthetic route.
In a 50 mL round bottomed flask, 3,5-dibromo-1H-1,2,4-triazole (lnt-1, 500 mg, 2.2 mmol) was dissolved in DMF (8 mL) and potassium carbonate (680 mg, 4.87 mmol) was added. After stirring for 20 min at room temperature, 2,2,3,3, 3-pentafluoropropyl trifluoromethanesulfonate (705 mg, 414 mu, 2.42 mmol) was added and the reaction mixture was stirred for 20 h at room temperature. After that, it was concentrated in vacuo, the residue was purified by column chromatography (silica gel, 50 g, eluting with ethyl acetate / n-heptane, gradient 20:80 to 50:50 v/v) to yield the title compound as white solid (409 mg, 52%). HPLC (methodLCMS_fastgradient) tR= 1.11 min. 1H NMR (CDCl3, 300 MHz): delta 4.78 (t, J = 13.4 Hz, 2 H). MS (ES+) mJz 357.9, 359.9, 361.9 [M+H, 2 Br isotopes].
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Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
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