Some common heterocyclic compound, 10570-40-8, name is 4-Methyl-4H-1,2,4-triazole, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 4-Methyl-4H-1,2,4-triazole
A solution of 4-methyl-1,2,4-triazole (1:08 g, 13 mmol) and DNPH (2:60 g, 13 mmol) in CH2Cl2 (20 mL) was stirred at 20 C for 4 d. The product precipitated and was collected by filtration, washed with CH2Cl2 (5 mL) and Et2O (5 mL), and dried to yield 2.45 g (67%) of a yellow powder. – 1H NMR (300 MHz, [D6]DMSO): delta = 3:84 (s, 3H), 6.32 (d, J =9:7 Hz, 1H), 7.41 (s, 2H), 7.77 (dd, J = 9.7 Hz, J = 3.1 Hz, 1H), 8.59 (d, J = 3.1 Hz, 1H), 8.98 (s, 1H), 9.98 ppm. – 13C NMR (75 MHz, [D6]DMSO): delta = 34:1, 125.0, 126.5, 127.4, 136.0, 140.7, 143.4, 170:3 ppm. – IR (neat): nu = 3294 w, 3236 w, 3081 m, 2988 m, 1595 s, 1550 m, 1525 s, 1475 m, 1431 m, 1371 m, 1307 s, 1258 s, 1175 m, 1128 s, 983 m, 834 s, 710 m, 654 m, 618 s cm-1. – C9H10N6O5 (282.21): calcd. C 38.30, H 3.57, N 29.78; found C 38.28, H 3.42, N 29.40.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 10570-40-8, its application will become more common.
Reference:
Article; Laus, Gerhard; Kahlenberg, Volker; Wurst, Klaus; Schottenberger, Herwig; Zeitschrift fur Naturforschung – Section B Journal of Chemical Sciences; vol. 69; 9-10; (2014); p. 950 – 964;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics