These common heterocyclic compound, 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Formula: C8H8N4
3-Phenyl-1,2,4-triazol-5-amine (12, 3.20 g, 20 mmol) was dissolved in cold DMF (8 mL). Carbondisulphide (1.2 mL, 20 mmol) was added drop-wise, followed by 10 N KOH solution (2 mL, 20 mmol).The reaction mixture was stirred for 1 h on an ice-bath. Iodomethane (1.25 mL, 20 mmol) was added,and stirring was continued for 10 min. Subsequently, the ice-bath was removed and the reactionmixture was stirred for 2 h. Cold water (15 mL) was added to the mixture, the yellow precipitate wasfiltered, washed with water, dried and recrystalized from EtOH. Yield 80 mg, 32%; mp 207-209 C(EtOH). 1H-NMR (300 MHz, DMSO-d6): 2.63 (3H, s, SMe), 7.47-7.57 (3H, m, H-30, H-40 and H-50),8.03 (2H, dd, J = 6.8, 3.0 Hz, H-20 and H-60), 8.64 (2H, s, NH2). 13C-NMR (75 MHz, DMSO-d6): 18.8,126.6 (2C), 128.8 (2C), 129.1, 130.6, 157.5, 158.8, 199.5. Combustion elemental analysis calculated forC10H10N4S2: C, 47.98; H, 4.03; N, 22.38. Found: C, 48.06; H, 4.12; N, 22.14.
The synthetic route of 5-Phenyl-1H-1,2,4-triazol-3-amine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Junaid, Ahmad; Lim, Felicia Phei Lin; Zhou, Yvonne Peijun; Chui, Wai Keung; Dolzhenko, Anton V.; Molecules; vol. 24; 8; (2019);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics