Szaboo, Nikoletta’s team published research in Expert Opinion on Drug Metabolism & Toxicology in 7 | CAS: 377727-87-2

Expert Opinion on Drug Metabolism & Toxicology published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C8H6ClF3, HPLC of Formula: 377727-87-2.

Szaboo, Nikoletta published the artcileNovel therapy in Parkinson’s disease: adenosine A2A receptor antagonists, HPLC of Formula: 377727-87-2, the publication is Expert Opinion on Drug Metabolism & Toxicology (2011), 7(4), 441-455, database is CAplus and MEDLINE.

A review. Introduction: Parkinson’s disease (PD) is a progressive neurodegenerative disorder. To date, most of the currently available therapies in PD target the dopaminergic system and none of these therapeutic approaches have been proven to modify the course of the disease. To various extents, these drugs can also cause motor and non-motor complications. A novel target, the adenosine A2A receptor (AA2AR), was recently identified, blockade of which may alleviate Parkinsonian symptoms, reduce motor fluctuations and potentially afford neuroprotection. Areas covered: This review is based on a PubMed search covering the relationship of the adenosine receptors and PD. The role of the AA2AR is reviewed and the results of preclin. investigations of antagonists are assessed. A synopsis of current drug development is provided, with a special focus on the pharmacokinetics and relevant clin. trials. Expert opinion: The localization of the AA2AR in the central nervous system, the ultra structural localization and the mol. mechanism of its action reveal the potential importance of the AA2AR in movement disorders. The theor. background and exptl. data indicate that AA2AR antagonists may have a potential therapeutic effect in Parkinson’s disease. More importantly, the putative neuroprotective effect needs further investigation.

Expert Opinion on Drug Metabolism & Toxicology published new progress about 377727-87-2. 377727-87-2 belongs to triazoles, auxiliary class GPCR/G Protein,Adenosine Receptor, name is 2-(Furan-2-yl)-7-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, and the molecular formula is C8H6ClF3, HPLC of Formula: 377727-87-2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics