Tag: 0-100

In 2019,Organic Letters included an article by Roshandel, Sahar; Lunn, Maiko J.; Rasul, Golam; Muthiah Ravinson, Daniel Sylvinson; Suri, Suresh C.; Prakash, G. K. Surya. SDS of cas: 288-36-8. The article was titled 《Catalyst-Free Regioselective N2 Arylation of 1,2,3-Triazoles Using Diaryl Iodonium Salts》. The information in the text is summarized as follows:

The widespread application of 1,2,3-triazoles in pharmaceuticals has resulted in substantial interest toward developing efficient postmodification methods. Whereas there are many postmodification methods available to obtain N1-substituted 1,2,3-triazoles, developing a selective and convenient protocol to synthesize N2-aryl-1,2,3-triazoles has been challenging. A catalyst-free and regioselective method to access N2-aryl-1,2,3-triazoles in good to excellent yields (66-97%), is reported. This scalable postmodification protocol is effective for a wide range of substrates. The experimental process involved the reaction of 1H-1,2,3-Triazole(cas: 288-36-8SDS of cas: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties SDS of cas: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Salinas-Torres, Angelica; Portilla, Jaime; Rojas, Hugo; Becerra, Diana; Castillo, Juan-Carlos published an article in Molbank. The title of the article was 《Synthesis, Spectroscopic Analysis, and In Vitro Anticancer Evaluation of 2-(Phenylsulfonyl)-2H-1,2,3-triazole》.Application of 288-36-8 The author mentioned the following in the article:

The 1,2,3-triazole derivatives containing the sulfonyl group have proved their biol. importance in medicinal chem. and drug design. In this sense, the regioselective synthesis of 2-(phenylsulfonyl)-2H-1,2,3-triazole in good yield through a classical sulfonamidation reaction of 1H-1,2,3-triazole with benzenesulfonyl chloride in dichloromethane using a slight excess of triethylamine at 20° for 3 h is described. This procedure is distinguished by its short reaction time, high yield, excellent regioselectivity, clean reaction profile, and operational simplicity. The sulfonamide exhibited moderate activity against UO-31 renal, SNB-75 central nervous system, HCT-116 colon, and BT-549 breast cancer cell lines, with growth inhibition percentages (GI%) ranging from 10.83% to 17.64%. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 288-36-8In 2020 ,《Imidazole-Selective Alkyne Hydroamination under Physiological Conditions》 appeared in Organic Letters. The author of the article were Kang, Hyung-Joon; Lee, Joon-Ho; Kim, Dong-Hyun; Cho, Cheon-Gyu. The article conveys some information:

Imidazole-selective intermol. hydroamination reaction has been discovered. This unprecedented additive-free addition reaction proceeds in an exclusively regioselective and stereoselective manner with high atom economy under extremely mild reaction conditions. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Related Products of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Electric Literature of C2H3N3In 2022 ,《Rational design of Striga hermonthica-specific seed germination inhibitors》 was published in Plant Physiology. The article was written by Zarban, Randa A.; Hameed, Umar F. Shahul; Jamil, Muhammad; Ota, Tsuyoshi; Wang, Jian You; Arold, Stefan T.; Asami, Tadao; Al-Babili, Salim. The article contains the following contents:

The obligate hemiparasitic weed Striga hermonthica grows on cereal roots and presents a severe threat to global food security by causing enormous yield losses, particularly in sub-Saharan Africa. The rapidly increasing Striga seed bank in infested soils provides a major obstacle in controlling this weed. Striga seeds require host-derived strigolactones (SLs) for germination, and corresponding antagonists could be used as germination inhibitors. Recently, we demonstrated that the common detergent Triton X-100 is a specific inhibitor of Striga seed germination by binding noncovalently to its receptor, S. hermonthica HYPO-SENSITIVE TO LIGHT 7 (ShHTL7), without blocking the rice (Oryza sativa) SL receptor DWARF14 (OsD14). Moreover, triazole ureas, the potent covalently binding antagonists of rice SL perception with much higher activity toward OsD14, showed inhibition of Striga but were less specific. Considering that Triton X-100 is not suitable for field application and by combining structural elements of Triton and triazole urea, we developed two hybrid compounds, KK023-N1 and KK023-N2, as potential Striga-specific germination inhibitors. Both compounds blocked the hydrolysis activity of ShHTL7 but did not affect that of OsD14. Binding of KK023-N1 diminished ShHTL7 interaction with S. hermonthica MORE AXILLARY BRANCHING 2, a major component in SL signal transduction, and increased ShHTL7 thermal specificity. Docking studies indicate that KK023-N1 binding is not covalent but is caused by hydrophobic interactions. Finally, in vitro and greenhouse tests revealed specific inhibition of Striga seed germination, which led to a 38% reduction in Striga infestation in pot experiments These findings reveal that KK023-N1 is a potential candidate for combating Striga and a promising basis for rational design and development of further Striga-specific herbicides.1H-1,2,3-Triazole(cas: 288-36-8Electric Literature of C2H3N3) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Electric Literature of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Triazole Ureas Covalently Bind to Strigolactone Receptor and Antagonize Strigolactone Responses》 were Nakamura, Hidemitsu; Hirabayashi, Kei; Miyakawa, Takuya; Kikuzato, Ko; Hu, Wenqian; Xu, Yuqun; Jiang, Kai; Takahashi, Ikuo; Niiyama, Ruri; Dohmae, Naoshi; Tanokura, Masaru; Asami, Tadao. And the article was published in Molecular Plant in 2019. Application In Synthesis of 1H-1,2,3-Triazole The author mentioned the following in the article:

Strigolactones, a class of plant hormones with multiple functions, mediate plant-plant and plant-microorganism communications in the rhizosphere. In this study, we developed potent strigolactone antagonists, which covalently bind to the strigolactone receptor D14, by preparing an array of triazole urea compounds Using yeast two-hybrid and rice-tillering assays, we identified a triazole urea compound KK094 as a potent inhibitor of strigolactone receptors. Liquid chromatog.-tandem mass spectrometry anal. and X-ray crystallog. revealed that KK094 was hydrolyzed by D14, and that a reaction product of this degradation covalently binds to the Ser residue of the catalytic triad of D14. Furthermore, we identified two triazole urea compounds KK052 and KK073, whose effects on D14-D53/D14-SLR1 complex formation were opposite due to the absence (KK052) or presence (KK073) of a trifluoromethyl group on their Ph ring. These results demonstrate that triazole urea compounds are potentially powerful tools for agricultural application and may be useful for the elucidation of the complicated mechanism underlying strigolactone perception. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Application In Synthesis of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application In Synthesis of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Cooperative Large-Hysteresis Spin-Crossover Transition in the Iron(II) Triazolate [Fe(ta)2] Metal-Organic Framework》 was written by Grzywa, Maciej; Roess-Ohlenroth, Richard; Muschielok, Christoph; Oberhofer, Harald; Blachowski, Artur; Zukrowski, Jan; Vieweg, Dana; von Nidda, Hans-Albrecht Krug; Volkmer, Dirk. Product Details of 288-36-8 And the article was included in Inorganic Chemistry in 2020. The article conveys some information:

The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) containing Fe(II) ions and 1,2,3-triazolate ligands shows a reversible phase transition while retaining the cubic crystal symmetry and space group Fd3m. The phase transition between room temperature (RT-[Fe(ta)2]; a 16.6315(2) Å, V = 4600.39(8) Å3) and high temperature (HT-[Fe(ta)2]; a 17.7566(4) Å, V = 5598.6(1) Å3) phases occurs at a temperature >290°, whereas the phase transition between HT- and RT-[Fe(ta)2] starts at a temperature <210°. Both [Fe(ta)2] polymorphs have identical bond topologies, but they differ by a large increase of the unit cell's volume of 22% for HT-[Fe(ta)2]. The compounds were characterized by powder x-ray diffraction, DSC, and thermogravimetric analyses. Addnl., Mossbauer spectroscopy, magnetic studies, and the electronic structure of both phases are discussed in detail with respect to the spin-crossover transition from the low-spin (RT-[Fe(ta)2]) to the high-spin phase (HT-[Fe(ta)2]). The metal-organic framework [Fe(ta)2] (Hta = 1H-1,2,3-triazole) shows a reversible coordinative wide-hysteresis phase transition >290° without change of the cubic crystal system and space group. A large difference in the unit cell lengths is observed between the low-spin RT-[Fe(ta)2] (a 16.6315(2) Å, V = 4600.39(8) Å3) and high-spin HT-[Fe(ta)2] (a 17.7566(4) Å, V = 5598.6(1) Å3) phases, which were studied in detail by Mossbauer spectroscopy, DSC, and VT-PXRD. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Two ways of spin crossover in an iron(II) coordination polymer associated with conformational changes of a bridging ligand》 was published in Dalton Transactions in 2020. These research results belong to Ksiazek, Maria; Weselski, Marek; Dreczko, Agnieszka; Maliuzhenko, Vladyslav; Kazmierczak, Marcin; Toloczko, Aleksandra; Kusz, Joachim; Bronisz, Robert. Name: 1H-1,2,3-Triazole The article mentions the following:

1,4-Di(1-ethyl-1,2,3-triazol-5-yl)butane (bbtre) was prepared by lithiation of 1-ethyl-1,2,3-triazole, followed by alkylation with 1,4-dibromobutane. The ligand bbtre forms a three-dimensional network with Fe(II), [Fe(bbtre)3](ClO4)2·2CH3CN, that exhibits thermally induced spin crossover (SCO). A change of temperature or change of spin state results in various types of structural transformation, leading to different structures that are stable in strictly defined temperature ranges. As a result, there are three spin crossover transitions arranged via two different paths. Thus, cooling <280 K involves a HT(HS) → LT(HS) (HT, high temperature structure; LT, low temperature structure; HS, high spin) phase transition (PT), which is associated with conformational changes of the bbtre mols. and with deformation of the polymeric skeleton. In the LT phase incomplete and reversible LT(HS) ⇄ LT(HS/LS) spin crossover occurs (LS, low spin). In contrast, rapid cooling (of a sample not previously thermally treated) allows the HT(HS) → LT(HS) phase transition to be avoided, and so complete HT(HS) → HT1(LS) SCO occurs. This means that the PT plays the role of a switch, which allows a choice of one of two ways in which the SCO will proceed. After rapid cooling, further heating to 150 K and subsequent cooling results in a reversible HT1(HS) ⇄ HT1(LS) spin crossover (T↓1/2 = 130 K, T↑1/2 = 131 K). However, raising the temperature to 170-200 K gives a modulated structure HT2(HS) exhibiting the next reversible HT2(HS) ⇄ HT2(LS) SCO (T↓1/2 = 121 K, T↑1/2 = 123 K). Finally, heating >200 K involves the HT2(HS) → LT(HS) PT and results in a LT(HS) structure exhibiting incomplete LT(HS) ⇄ LT(HS/LS) spin crossover. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, optimization, antifungal activity, selectivity, and CYP51 binding of new 2-aryl-3-azolyl-1-indolyl-propan-2-ols》 was published in Pharmaceuticals in 2020. These research results belong to Lebouvier, Nicolas; Pagniez, Fabrice; Na, Young Min; Shi, Da; Pinson, Patricia; Marchivie, Mathieu; Guillon, Jean; Hakki, Tarek; Bernhardt, Rita; Yee, Sook Wah; Simons, Claire; Leze, Marie-Pierre; Hartmann, Rolf W.; Mularoni, Angelique; Le Baut, Guillaume; Krimm, Isabelle; Abagyan, Ruben; Le Pape, Patrice; Le Borgne, Marc. Safety of 1H-1,2,3-Triazole The article mentions the following:

A series of 2-aryl-3-azolyl-1-indolyl-propan-2-ols was designed as new analogs of fluconazole in two different chem. approaches. The first one, in seven steps, involved the synthesis of the key intermediate 1-(1H-benzotriazol-1-yl)methyl-1H-indole and the final opening of oxiranes by imidazole or 1H-1,2,4-triazole. The second route allowed access to the target compounds in only three steps, this time with the ring opening by indole and analogs. Twenty azole derivatives were tested against Candida albicans and other Candida species. The enantiomers of the best anti-Candida compound, 2-(2,4-dichlorophenyl)-3-(1H-indol-1-yl)-1-(1H-1,2,4-triazol-1-yl)-propan-2-ol, were analyzed by X-ray diffraction to determine their absolute configuration. The S-isomer (MIC = IC80 = 0.000256μg/mL on C. albicans CA98001) was found with the S-absolute configuration. In contrast the R-isomer was (MIC = 0.023μg/mL). Addnl., mol. docking calculations and mol. dynamics simulations were carried out using a crystal structure of Candida albicans lanosterol 14α-demethylase (CaCYP51). The S-isomer aligned with the positioning of posaconazole within both the heme and access channel binding sites, which was consistent with its biol. results. All target compounds have been also studied against human fetal lung fibroblast (MRC-5) cells. Finally, the selectivity of four compounds on a panel of human P 450-dependent enzymes (CYP19, CYP17, CYP26A1, CYP11B1, and CYP11B2) was investigated. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Hexadecanuclear MnII2MnIII14 Molecular Torus Built from in Situ Tandem Ligand Transformations》 were Riaz, Muhammad; Gupta, Rakesh Kumar; Su, Hai-Feng; Jaglicic, Zvonko; Kurmoo, Mohamedally; Tung, Chen-Ho; Sun, Di; Zheng, Lan-Sun. And the article was published in Inorganic Chemistry in 2019. Formula: C2H3N3 The author mentioned the following in the article:

A mixed-valent hexadecanuclear manganese cluster, [MnII2MnIII14(trz)14(thetach)4(μ3-O)8(H2O)10](ClO4)6 (Mn16), containing two MnII and 14 MnIII ions, is constructed from mixed in situ generated ligands, 1,2,3-triazole (Htrz) and 1,3,5-tri(2-hydroxyethyl)-1,3,5-triazacyclohexane (H3thetach). Remarkably, both ligands were not initially added into the reaction system, and their formations involve the in situ ligand decomposition and subsequent condensation reactions. The core of Mn16 is an elongated torus comprised of eight Mn atoms and four [Mn2O2] subunits bridged by oxo or alkoxide. The high-resolution electrospray ionization mass spectrometry (HR-ESI-MS) of Mn16 dissolved in CH3CN indicates its structure remains intact as +3 and +4 species. Temperature and field dependent magnetization revealed predominantly antiferromagnetic exchange interactions within the cluster. The work provides 1-pot synthesis of high-nuclearity manganese clusters using the ligands generated by in situ reactions in a tandem fashion. A new strategy was uncovered consisting of a tandem in situ formation of two ligands which subsequently construct a hexadecanuclear mixed-valent manganese sym. torus. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Huang, Wenhuan; Qiu, Qiang; Yang, Xiufang; Zuo, Shouwei; Bai, Jianan; Zhang, Huabin; Pei, Ke; Che, Renchao published an article in Nano-Micro Letters. The title of the article was 《Ultrahigh density of atomic CoFe-electron synergy in noncontinuous carbon matrix for highly efficient magnetic wave adsorption》.Formula: C2H3N3 The author mentioned the following in the article:

Improving the atom utilization of metals and clarifying the M-M’ interaction is both greatly significant in assembling high-performance ultra-light electromagnetic wave-absorbing materials. Herein, a high-temperature explosion strategy has been successfully applied to assemble the hierarchical porous carbon sponge with Co-Fe decoration via the pyrolysis of the energetic metal organic framework. The as-constructed hybrid displays a superior reflection loss (RL) value of – 57.7 dB and a specific RL value of – 192 dB mg-1 mm-1 at 12.08 GHz with a layer thickness of 2.0 mm (loading of 15 wt%). The off-axis electron hologram characterizes the highly distributed numerous polarized nanodomain variable capacitors, demonstrating the dipole and interfacial polarization along the edges of the nanopores. More importantly, the X-ray absorption spectroscopy anal. verifies the mutual interaction between the metal cluster and carbon matrix and the electronic coupling responsible for the greatly improved electromagnetic wave absorption. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics