Tag: 0-100

In 2022,Cui, Menghan; Wang, Rong; Yang, Qing; Kuang, Chunxiang published an article in Journal of Organic Chemistry. The title of the article was 《Copper-Promoted One-Pot Sandmeyer-Type Reaction for the Synthesis of N-Aryltriazoles》.Category: triazoles The author mentioned the following in the article:

Herein, the copper-catalyzed one-pot Sandmeyer-type reaction of aromatic amines with triazoles to afford N-aryl-1,2,3-triazoles such as I [Ar = Ph, 4-MeC6H4, 2-naphthyl, etc.; R = H, 4-Me, 3-Me, 4-C(O)OMe, 4-Ph; X1 = N, CH; X2 = N, CH;] was reported. Diazonium salts, formed from aromatic amines and tert-Bu nitrite in the presence of fluoroboric acid, reacted with triazoles in a copper-catalyzed Sandmeyer-type reaction. The reaction proceeded under mild conditions to afford N-aryltriazoles such as I in moderate to good yields. This method was amenable to a wide range of aromatic amines and triazoles and showed diverse functional group tolerance. Inhibition of the reaction upon the addition of free radical scavengers suggested a radical pathway, in which the aryl radical, copper, and triazole formed a complex that underwent reductive elimination to gave aryltriazole compounds such as I; this was consistent with the mechanism underlying the Sandmeyer reaction. Thus, a new effective strategy for the construction of C-N bonds via Sandmeyer-type reactions and a valuable alternative approach for the synthesis of aryltriazole derivs such as I was demonstrated. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Name: 1H-1,2,3-TriazoleIn 2021 ,《Azole as privileged heterocycle for targeting the inducible cyclooxygenase enzyme》 appeared in Drug Development Research. The author of the article were Prasher, Parteek; Sharma, Mousmee. The article conveys some information:

A review. An over-expression of COX-2 isoenzyme belonging to the Cyclooxygenase Enzyme Family triggers the overproduction of pro-inflammatory prostaglandins that instigate the development of chronic inflammation and related disorders. Hence, the rationally designed drugs for mitigating over-activity of COX-2 isoenzyme play a regulatory role toward the alleviation of the progression of these disorders. However, a selective COX-2 inhibition chemotherapy prompts several side effects that necessitate the identification of novel mol. scaffolds for deliberating state-of-the-art drug designing strategies. The heterocyclic “”azole”” scaffold, being polar and hydrophilic, possesses remarkable physicochem. advantages for designing physiol. active mols. capable of interacting with a wide range of biol. components, including enzymes, peptides, and metabolites. The substituted derivatives of azole nuclei enable a comprehensive SAR anal. for the appraisal of bioactive profile of the deliberated mols. for obtaining the rationally designed compounds with prominent activities. The comprehensive SAR anal. readily prompted the identification of Y-shaped mols. and the eminence of bulkier group for COX-2 selective inhibition. This review presents an epigrammatic collation of the pharmacophore-profile of the chemotherapeutics based on azole motif for a selective targeting of the COX-2 isoenzyme. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Name: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Name: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Copper-Catalyzed Oxidative C-H Bond Functionalization of N-Allylbenzamide for Regioselective C-N and C-O Bond Formation》 was written by Ranjith, Jala; Krishna, Palakodety Radha. Synthetic Route of C2H3N3This research focused ontriazole allylbenzamide copper catalyst oxidative carbon nitrogen bond formation; amino imide preparation; allylbenzamide copper catalyst hydrogen carbon oxygen bond functionalization regioselective; imide preparation; copper; imides; oxidative coupling; oxo-amination; regioselectivity. The article conveys some information:

Copper-catalyzed oxidative couplings of N-allylbenzamides for C-N and C-O bond formations have been developed through C-H bond functionalization. To demonstrate the utility of this approach, it was applied to the synthesis of β-aminoimides and imides. To the best of our knowledge, these are the first examples in which different classes of N-containing compounds have been directly prepared from the readily available N-allylbenzamides using an inexpensive catalyst/oxidant/base (CuSO4/TBHP/Cs2CO3) system. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Sandahl, Alexander F.; Nguyen, Thuy J. D.; Hansen, Rikke A.; Johansen, Martin B.; Skrydstrup, Troels; Gothelf, Kurt V. published an article in 2021. The article was titled 《On-demand synthesis of phosphoramidites》, and you may find the article in Nature Communications.Product Details of 288-36-8 The information in the text is summarized as follows:

Automated chem. synthesis of oligonucleotides is of fundamental importance for the production of primers for the polymerase chain reaction (PCR), for oligonucleotide-based drugs, and for numerous other medical and biotechnol. applications. The highly optimized automised chem. oligonucleotide synthesis relies upon phosphoramidites as the phosphate precursors and one of the drawbacks of this technol. is the poor bench stability of phosphoramidites. Here, we report on the development of an on-demand flow synthesis of phosphoramidites from their corresponding alcs., which is accomplished with short reaction times, near-quant. yields and without the need of purification before being submitted directly to automated oligonucleotide synthesis. Sterically hindered as well as redox unstable phosphoramidites are synthesized using this methodol. and the subsequent couplings are near-quant. for all substrates. The vision for this technol. is direct integration into DNA synthesizers thereby omitting manual synthesis and storage of phosphoramidites. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Product Details of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Product Details of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Pesticide Biochemistry and Physiology included an article by Yan, Wei; Wang, Xing; Li, Ke; Li, Tian-Xi; Wang, Jia-Jie; Yao, Kai-Cheng; Cao, Ling-Ling; Zhao, Shuang-Shuang; Ye, Yong-Hao. Category: triazoles. The article was titled 《Design, synthesis, and antifungal activity of carboxamide derivatives possessing 1,2,3-triazole as potential succinate dehydrogenase inhibitors》. The information in the text is summarized as follows:

Succinate dehydrogenase (SDH) is demonstrably one of the most important mol. targets in development of new fungicide. In our continuous efforts to discover novel SDH inhibitors, forty-two carboxamide derivatives containing 1,2,3-triazole ring were designed and synthesized, which were precisely characterized by 1H NMR, ESI-MS, elemental anal. and X-ray single-crystal diffraction. The compounds were screened for antifungal activities against phytopathogenic fungi by mycelia growth inhibition assay in vitro. Compound A3-3 exhibited significant antifungal activity against Sclerotinia sclerotiorum, Botrytis cinerea, Rhizoctonia cerealis and Gaeumannomyces graminsis with EC50 values of 1.08, 8.75, 1.67 and 5.30μg/mL, resp., comparable to those of com. SDHI boscalid. In vivo testing demonstrated that A3-3 was effective for suppressing rape sclerotinia rot, cucumber gray mold and wheat powdery mildew caused by S. sclerotiorum, B. cinerea and Blumeria graminis at a dosage of 200μg/mL. Inhibition activities against SDH test proved the designed analogs were effective in the enzyme level. The mol. docking simulation revealed that A3-3 interacted with ARG43, TYR58 and TRP173 of the SDH through hydrogen bond and pi-pi interaction, which could explain the probable mechanism of action between the inhibitor and target protein.1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Kumar Ghosh, Asim; Neogi, Sukanya; Das, Krishna Kanta; Hajra, Alakananda published an article in Journal of Organic Chemistry. The title of the article was 《Organocatalytic Oxidative C-H Amination of Aldehyde Hydrazones with Azoles at Ambient Temperature》.Safety of 1H-1,2,3-Triazole The author mentioned the following in the article:

An efficient, metal-free, and direct oxidative amination of aldehyde-derived hydrazones R1CH=N-N(CH2)2X(CH2)2- (R1 = Ph, 2-bromo-5-chlorophenyl, naphthalen-1-yl, 2-methylphenyl, etc.; X = O, CH2) with azoles e.g., I has been developed using 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) as an organocatalyst under ambient temperature This protocol provides a wide range of aminated hydrazone derivatives II (R2 = 3,5-dimethyl-1H-pyrazol-1-yl, 2H-indazol-2-yl, 4-phenyl-1H-1,2,3-triazol-1-yl, etc.) in a step and atom economical fashion. The reaction possibly follows a radical mechanism.1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Li, Mingyue; Fu, Yaomei; You, Siqi; Yang, Yu; Qin, Chao; Zhao, Liang; Su, Zhongmin published an article in 2021. The article was titled 《Hexanuclear nickel-based [P4Mo11O50] with photocatalytic reduction of CO2 activity》, and you may find the article in Inorganic Chemistry Communications.Related Products of 288-36-8 The information in the text is summarized as follows:

A new polyoxometalate based organic-inorganic hybrid [Ni6(trz)2(Htrz)13][H4P4Mo11O50]·7H2O (1), constructed from a hexanuclear [Ni6(trz)2(Htrz)13] building block and a new polyoxometalate [H4P4Mo11O50] cluster, was synthesized under a hydrothermal condition. In this 3D structure, each [Ni6(trz)2(Htrz)13] secondary building unit (SBU) connects with four neighbored [Ni6(trz)2(Htrz)13] and four [H4P4Mo11O50] clusters, forming an eight-connected node. While each [H4P4Mo11O50] cluster bridges four [Ni6(trz)2(Htrz)13] SBUs as a four-connected node. So the 3D framework of 1 can be simplified to a binodal (4,8)-connected gsp2 topol. with point symbol [44·62][416·612]. The photocatalytic reduction of CO2 under visible light reveals that the highest yield of CO was 689.86μmol g-1 when 1 is used as catalyst, Ru(bpy)3Cl2 as a photosensitizer and TEOA as a sacrificial agent. The mechanism of the photoreduction of CO2 is confirmed by Mott-Schottky, photocurrent, and fluorescence quenching experiments This research provides a new strategy for the design of cheap and efficient POM-based photocatalysts. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Related Products of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Triazolium-Based Ionic Liquids: A Novel Class of Cellulose Solvents》 was written by Brehm, Martin; Pulst, Martin; Kressler, Joerg; Sebastiani, Daniel. Safety of 1H-1,2,3-TriazoleThis research focused ontriazolium ionic liquid cellulose solvent solubility synthesis MD simulation. The article conveys some information:

We present first results on triazolium-based ionic liquids (ILs) as a novel class of nonderivatizing solvents for cellulose. Despite their chem. similarity to imidazolium cations, the 1,2,3-triazolium cation lacks the isolated ring proton, leading to reduced formation of N-heterocyclic carbenes (NHCs) and therefore to lower reactivity and less unwanted side reactions. We synthesized six ILs based on 1,2,3-triazolium and 1,2,4-triazolium cations. The acetates are room-temperature ionic liquids and dissolve a similar amount of cellulose as the corresponding imidazolium salt. From NMR spectroscopy of the solution, we rule out polymer degradation The cellulose solubility rises with increasing anion basicity, while being almost independent of the cation. We perform mol. dynamics simulations and compute enthalpies of solvation, which quant. fit the exptl. solubilities. Trajectory anal. reveals strong hydrogen bonds between acetate anions and cellulose hydroxyl groups, while the cations do not form strong hydrogen bonds with cellulose. Thus, the simulations provide an atomistic explanation of our exptl. observations. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Safety of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Safety of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Highly Selective Separation of C3H8 and C2H2 from CH4 within Two Water-Stable Zn5 Cluster-Based Metal-Organic Frameworks》 was written by Kan, Liang; Li, Guanghua; Liu, Yunling. HPLC of Formula: 288-36-8This research focused ontriazole zinc triazolediyldiisophthalate terphenyltetracarboxylate metal organic framework preparation structure; crystal structure triazole zinc triazolediyldiisophthalate terphenyltetracarboxylate MOF; propane acetylene methane gas separation triazole zinc triazolediyldiisophthalate terphenyltetracarboxylate; JLU MOF66 MOF67 preparation crystal mol structure gas separation; acetylene; gas separation; metal−organic frameworks; propane; water stability. The article conveys some information:

Adopting the mixed ligands approach, two water-stable Zn5 cluster-based MOFs, [Zn10(TZ)12(TADIPA)2(DMF)4]·DMF·6H2O (JLU-MOF66) and [Zn10(TZ)12(TPTA)2(DMA)2]·2DMA·4H2O (JLU-MOF67), have been constructed (H4TADIPA = 5,5′-(1H-1,2,4-triazole-3,5-diyl)diisophthalic acid, H4TPTA = [1,1′:3′,1”-terphenyl]-3,3”,5,5”-tetracarboxylic acid, and HTZ = 1H-[1,2,3]triazole). Both compounds with [Zn5(TZ)6] clusters exhibit extraordinary stability (pH = 2-11) and selectivity of C3H8/CH4 (308 for JLU-MOF66, and 287 for JLU-MOF67). Compared to JLU-MOF67, JLU-MOF66 with functional groups exhibits higher CO2 and C2H2 uptake capacity and excellent selective separation for C2H2/CH4 (86, 1:1). Such high separation and chem. stability render them as promising materials for industrial applications. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties HPLC of Formula: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Andreeva, Anastasia B.; Le, Khoa N.; Kadota, Kentaro; Horike, Satoshi; Hendon, Christopher H.; Brozek, Carl K. published their research in Chemistry of Materials in 2021. The article was titled 《Cooperativity and Metal-Linker Dynamics in Spin Crossover Framework Fe(1,2,3-triazolate)2》.COA of Formula: C2H3N3 The article contains the following contents:

Cooperative interactions are responsible for the useful properties of spin crossover (SCO) materials-large hysteresis windows, critical temperatures near room temperature, and abrupt transitions-with hybrid framework materials exhibiting the greatest cooperativity and hysteresis of all SCO systems. However, little is known about the chem. origin of cooperativity in frameworks. Here, the authors present a combined exptl.-computational approach for identifying the origin of cooperativity in the metal-organic framework (MOF) Fe(1,2,3-triazolate)2 (Fe(TA)2), which exhibits the largest known hysteresis window of all SCO materials and unusually high transition temperatures, as a roadmap for understanding the manipulation of SCO behavior in general. Variable-temperature vibrational spectroscopy provides evidence that soft modes associated with dynamic metal-linker bonding trigger the cooperative SCO transition. Thermodn. anal. also confirms a cooperativity magnitude much larger than those of other SCO systems, while electron d. calculations of Fe(TA)2 support previous theor. predictions that large cooperativity arises in materials where SCO produces considerable differences in metal-ligand bond polarities between different spin states. Taken together, this combined exptl.-computational study provides a microscopic basis for understanding cooperative magnetism and highlights the important role of dynamic bonding in the functional behavior of framework materials. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics