Tag: 0-100

In 2022,Desai, Shrey P.; Zambri, Matthew T.; Taylor, Mark S. published an article in Journal of Organic Chemistry. The title of the article was 《Borinic Acid Catalyzed Regioselective N-Alkylation of Azoles》.Category: triazoles The author mentioned the following in the article:

A method for regioselective N-alkylation of ambident, azole-type heterocycles with alkene or epoxide electrophiles is described. In the presence of diphenylborinic acid (Ph2BOH) and an amine cocatalyst, heterocyclic nucleophiles such as 1,2,3- and 1,2,4-triazoles, substituted tetrazoles, and purine are activated toward selective N-functionalization. The scope of electrophilic partners includes enones, 2-vinylpyridine, Ph vinyl sulfone, a dehydroalanine derivative, and epoxides. Mechanistic studies, including in situ 11B NMR spectroscopy and kinetic anal., are discussed. The results came from multiple reactions, including the reaction of 1H-1,2,3-Triazole(cas: 288-36-8Category: triazoles)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Buglioni, Laura; Beslac, Marko; Noel, Timothy published their research in Journal of Organic Chemistry in 2021. The article was titled 《Dehydrogenative Azolation of Arenes in a Microflow Electrochemical Reactor》.Related Products of 288-36-8 The article contains the following contents:

The electrochem. synthesis of aryl azoles was performed for the first time in a microflow reactor. The reaction relies on the anodic oxidation of the arene partners making these substrates susceptible for C-H functionalization with azoles, thus requiring no homogeneous transition-metal-based catalysts. The synthetic protocol benefits from the implementation of a microflow setup, leading to shorter residence times (10 min) compared to previously reported batch systems. Various azolated compounds are obtained in good to excellent yields. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Related Products of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Thermochemistry and Initial Decomposition Pathways of Triazole Energetic Materials》 was written by Lu, Meiheng; Zhou, Panwang; Yang, Yanqiang; Liu, Jianyong; Jin, Bing; Han, Keli. Recommanded Product: 1H-1,2,3-TriazoleThis research focused ontriazole nitrotriazole isomer thermal decomposition. The article conveys some information:

A thorough investigation of the initial decomposition pathways of triazoles and their nitro-substituted derivatives has been conducted using the MP2 method for optimization and DLPNO-CCSD(T) method for energy. Different initial thermolysis mechanisms are proposed for 1,2,4-triazole and 1,2,3-triazole, the two kinds of triazoles. The higher energy barrier of the primary decomposition path of 1,2,4-triazole (H-transfer path, ~52 kcal/mol) compared with that of 1,2,3-triazole (ring-open path, ~45 kcal/mol) shows that 1,2,4-triazole is more stable, consistent with exptl. observations. For nitro-substituted triazoles, more dissociation channels associated with the nitro group have been obtained and found to be competitive with the primary decomposition paths of the triazole skeleton in some cases. Besides, the effect of the nitro group on the decomposition pattern of the triazole skeleton has been explored, and it has been found that the electron-withdrawing nitro group has an opposite effect on the primary dissociation channels of 1,2,4-triazole derivatives and 1,2,3-triazole derivatives1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 288-36-8In 2019 ,《Complexes of Zn(II)-Triazoles with CO2 and H2O: Structures, Energetics, and Applications》 was published in Journal of Physical Chemistry A. The article was written by Dahmani, Rahma; Grubisic, Sonja; Yaghlane, Saida Ben; Boughdiri, Salima; Hochlaf, Majdi. The article contains the following contents:

Using a first-principle methodol., DFT-M05-2X(+D3), we investigate the stable structures of the nonreactive and reactive clusters formed between Zn2+-triazoles ([Zn2+-Tz]) clusters and CO2 and/or H2O. In sum, we characterized two modes of bonding of [Zn2+-Tz] with CO2/H2O: the interaction is established through (i) a covalent bond between Zn2+ of [Zn2+-Tz] and oxygen atoms of CO2 or H2O and (ii) hydrogen bonds through N-H or C-H of [Zn2+-Tz] and oxygen atoms of H2O or CO2, N-H···O. We also identified intramol. proton transfer processes induced by complexation. Indeed, water drastically changes the shape of the energy profiles of the tautomeric phenomena through strong lowering of the potential barriers to tautomerism. The comparison to [Zn2+-Im] subunits formed with Zn2+ and imidazole shows that the efficiency of Tz-based compounds for CO2 capture and uptake is due to the incorporation of more accessible nitrogen donor sites in Tzs compared to imidazoles. Since [Zn2+-Tz] clusters are subunits of an organometallic nanoporous materials and Zn-proteins, our data are useful for deriving force fields for macromol. simulations of these materials. Our work also suggests the consideration of traces of water to better model the CO2 sequestration and reactivity on macromol. entities such as pores or active sites. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Synthesis, characterization and study of covalently modified triazole LAPONITE edges》 was written by Colletti, Carmelo Giuseppe; Massaro, Marina; Lazzara, Giuseppe; Cavallaro, Giuseppe; Milioto, Stefana; Pibiri, Ivana; Noto, Renato; Riela, Serena. HPLC of Formula: 288-36-8This research focused ontriazole LAPONITE supramol interaction dynamic light scattering. The article conveys some information:

LAPONITE (Lap) clay mineral was successful functionalized by triazole groups in a two steps procedure. First, the Lap edges were modified with 3-azidopropyltrimethoxysilane by traditional heating and microwave irradiation Microwave irradiation allowed us to obtain high loading onto the Lap edges in lower times compared to those obtained through conventional method. Afterwards, the triazole moieties were obtained by reaction between azido functionalized Lap and propargyl alc. The successful functionalization of Lap was proved by thermogravimetric anal., FT-IR spectroscopy, dynamic light scattering and ζ-potential measurements. Finally, the effects of the surface modification on the gel formation ability of Lap were studied by gelation tests and the morphol. of the gel phases was investigated by polarized optical microscopy measurements and diffusion experiments In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties HPLC of Formula: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,New Journal of Chemistry included an article by Re He Man, Xi Jia Ai Ti; Liu, Yong Chun; Li, Xiao Xiao; Zhao, Zhi Gang. HPLC of Formula: 288-36-8. The article was titled 《Highly N2-selective allylation of NH-1,2,3-triazoles with allenamides mediated by N-iodosuccinimide》. The information in the text is summarized as follows:

A new method was developed to synthesize N2-allyl-substituted 1,2,3-triazoles via NIS mediated allylation of allenamides with mono- and unsubstituted NH-1,2,3-triazoles and benzotriazole. All the N2-allyl-substituted 1,2,3-triazoles has relative stability. The ionic pair composed of a σ-complex and the conjugate base of the imide and the hydrogen bond between the conjugate base and NH-1,2,3-triazole were found to be generated, which selectively gave the desired N2-allylation products. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties HPLC of Formula: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Rachuru, Sanjeev; Vandanapu, Jagannadham; Skelton, Adam A. published their research in Australian Journal of Chemistry in 2021. The article was titled 《The pKa of Pentazole (HN5)》.HPLC of Formula: 288-36-8 The article contains the following contents:

Pentazole having the mol. formula HN5 is an archetypical five-membered homocyclic inorganic aromatic mol. consisting of five nitrogen atoms. A hydrogen atom is bonded to one of the nitrogens. Even though the mol. does not contain a carbon it appears last in the series of the heterocyclic azole family; the family containing one to five nitrogen atoms. This series of heterocyclic azoles is pyrrole, imidazole, pyrazole, triazole, tetrazole, and the last one is the pentazole. Barring pentazole, the rest of the members of the azole family are heterocyclic organic mols. The pKa of N(1)H-acidity values of all the azole members are known, except for that of pentazole. In the present work we endeavored to determine the pKa of pentazole by a graphical method and by performing theor. DFT calculations After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8HPLC of Formula: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties HPLC of Formula: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of C2H3N3In 2020 ,《Precise Preparation of a High-Purity Key Intermediate of Tazobactam》 was published in Organic Process Research & Development. The article was written by Zhou, Yanan; Wu, Chengjun; Ma, Hongzhi; Chen, Jianchao; Sun, Tiemin. The article contains the following contents:

In situ IR was used to precisely prepare high-purity diphenylmethyl 6α-bromopenicillanate 8 (VIII), a key intermediate of tazobactam (I). 8 Was obtained when 6α-bromopenicillanic acid 2 (II) reacted with diphenyldiazomethane (DDM). 2 Is unstable and must therefore react immediately with DDM upon preparation DDM is also unstable. As DDM decomposes rapidly upon preparation, the DDM content cannot be precisely determined using high-performance liquid chromatog. (HPLC) or gas chromatog. (GC). Therefore, good yield and purity are difficult to obtain, resulting in large batch-to-batch variations (yield 69.3-82.8%, purity 89.8-98.4%) for 8. The developed preparation method for 8 involved the use of in situ IR to monitor the reaction process and achieved good results (82.7-83.1% yield and 97.3-98.5% purity). This method was also used to prepare the key intermediate for the synthesis of cephalosporin derivatives, which have high industrial value. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

SDS of cas: 288-36-8In 2021 ,《Naphthoquinones and Derivatives for Chemotherapy: Perspectives and Limitations of their Anti-trypanosomatids Activities》 appeared in Current Pharmaceutical Design. The author of the article were Dantas-Pereira, Luiza; Cunha-Junior, Edezio F.; Andrade-Neto, Valter V.; Bower, John F.; Jardim, Guilherme A. M.; da Silva, Eufranio N. Junior; Torres-Santos, Eduardo C.; Menna-Barreto, Rubem F. S.. The article conveys some information:

A review. Chagas disease, Sleeping sickness and Leishmaniasis, caused by trypanosomatids Trypanosoma cruzi, Trypanosoma brucei and Leishmania spp., resp., are considered neglected tropical diseases, and they especially affect impoverished populations in the developing world. The available chemotherapies are very limited, and a search for alternatives is still necessary. In folk medicine, natural naphthoquinones have been employed for the treatment of a great variety of illnesses, including parasitic infections. This review is focused on the anti-trypanosomatid activity and mechanistic anal. of naphthoquinones and derivatives Among all the series of derivatives tested in vitro, naphthoquinone-derived 1,2,3-triazoles were very active on T. cruzi infective forms in blood bank conditions, as well as in amastigotes of Leishmania spp. naphthoquinones containing a CF3 on a Ph amine ring inhibited T. brucei proliferation in the nanomolar range, and naphthopterocarpanquinones stood out for their activity on a range of Leishmania species. Some of these compounds showed a promising selectivity index (SI) (30 to 1900), supporting further anal. in animal models. Indeed, high toxicity to the host and inactivation by blood components are crucial obstacles to be overcome to use naphthoquinones and/or their derivatives for chemotherapy. Multidisciplinary initiatives embracing medicinal chem., bioinformatics, biochem., and mol. and cellular biol. need to be encouraged to allow the optimization of these compounds Large scale automated tests are pivotal for the efficiency of the screening step, and subsequent evaluation of both the mechanism of action in vitro and pharmacokinetics in vivo is essential for the development of a novel, specific and safe derivative, minimizing adverse effects. In the experiment, the researchers used 1H-1,2,3-Triazole(cas: 288-36-8SDS of cas: 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties SDS of cas: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Formula: C2H3N3In 2019 ,《1,2,3-Triazole-containing hybrids as leads in medicinal chemistry: A recent overview》 appeared in Bioorganic & Medicinal Chemistry. The author of the article were Bozorov, Khurshed; Zhao, Jiangyu; Aisa, Haji A.. The article conveys some information:

A review. The 1,2,3-triazole ring is a major pharmacophore system among nitrogen-containing heterocycles. These five-membered heterocyclic motifs with three nitrogen heteroatoms can be prepared easily using ‘click’ chem. with copper- or ruthenium-catalyzed azide-alkyne cycloaddition reactions. Recently, the ‘linker’ property of 1,2,3-triazoles was demonstrated, and a novel class of 1,2,3-triazole-containing hybrids and conjugates was synthesized and evaluated as lead compounds for diverse biol. targets. These lead compounds have been demonstrated as anticancer, antimicrobial, anti-tubercular, antiviral, antidiabetic, antimalarial, anti-leishmanial, and neuroprotective agents. The present review summarises advances in lead compounds of 1,2,3-triazole-containing hybrids, conjugates, and their related heterocycles in medicinal chem. published in 2018. This review will be useful to scientists in research fields of organic synthesis, medicinal chem., phytochem., and pharmacol. After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics