Tag: 0-100

In 2019,International Journal of Molecular Sciences included an article by Harej, Anja; Macan, Andrijana Mescic; Stepanic, Visnja; Klobucar, Marko; Pavelic, Kresimir; Pavelic, Sandra Kraljevic; Raic-Malic, Silvana. Synthetic Route of C2H3N3. The article was titled 《The antioxidant and antiproliferative activities of 1,2,3-triazolyl-L-ascorbic acid derivatives》. The information in the text is summarized as follows:

The novel 4-substituted 1,2,3-triazole L-ascorbic acid (L-ASA) conjugates with hydroxyethylene spacer as well as their conformationally restricted 4,5-unsaturated analogs were synthesized as potential antioxidant and antiproliferative agents. An evaluation of the antioxidant activity of novel compounds showed that the majority of the 4,5-unsaturated L-ASA derivatives showed a better antioxidant activity compared to their saturated counterparts. m-Hydroxyphenyl (7j), p-pentylphenyl (7k) and 2-hydroxyethyl (7q) substituted 4,5-unsaturated 1,2,3-triazole L-ASA derivatives exhibited very efficient and rapid (within 5 min) 2,2-diphenyl-1-picrylhydrazyl (DPPH•) radical scavenging activity (7j, 7k: IC50 = 0.06 mM; 7q: IC50 = 0.07 mM). In vitro scavenging activity data were supported by in silico quantum-chem. modeling. Thermodn. parameters for hydrogen-atom transfer and electron-transfer radical scavenging pathways of anions deprotonated at C2-OH or C3-OH groups of L-ASA fragments were calculated The structure activity anal. (SAR) through principal component anal. indicated radical scavenging activity by the participation of OH group with favorable reaction parameters: the C3-OH group of saturated C4-C5(OH) derivatives and the C2-OH group of their unsaturated C4 = C5 analogs. The antiproliferative evaluation showed that p-bromophenyl (4e: IC50 = 6.72 μM) and p-pentylphenyl-substituted 1,2,3-triazole L-ASA conjugate (4k: IC50 = 26.91 μM) had a selective cytotoxic effect on breast adenocarcinoma MCF-7 cells. Moreover, compound 4e did not inhibit the growth of foreskin fibroblasts (IC50 > 100 μM). In MCF-7 cells treated with 4e, a significant increase of hydroxylated hypoxia-inducible transcription factor 1 alpha (HIF-1α) expression and decreased expression of nitric oxide synthase 2 (NOS2) were observed, suggesting the involvement of 4e in the HIF-1α signaling pathway for its strong growth-inhibition effect on MCF-7 cells. In the experimental materials used by the author, we found 1H-1,2,3-Triazole(cas: 288-36-8Synthetic Route of C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Synthetic Route of C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Quality Control of 1H-1,2,3-TriazoleIn 2021 ,《Characterizing and Contrasting Structural Proton Transport Mechanisms in Azole Hydrogen Bond Networks Using Ab Initio Molecular Dynamics》 appeared in Journal of Physical Chemistry Letters. The author of the article were Atsango, Austin O.; Tuckerman, Mark E.; Markland, Thomas E.. The article conveys some information:

Imidazole and 1,2,3-triazole are promising hydrogen-bonded heterocycles that conduct protons via a structural mechanism and whose derivatives are present in systems ranging from biol. proton channels to proton exchange membrane fuel cells. Here, the authors leverage multiple time-stepping to perform ab initio mol. dynamics of imidazole and 1,2,3-triazole at the nanosecond time scale. Despite the close structural similarities of these compounds, their proton diffusion constants vary by over an order of magnitude. The authors’ simulations reveal the reasons for these differences in diffusion constants, which range from the degree of hydrogen-bonded chain linearity to the effect of the central nitrogen atom in 1,2,3-triazole on proton transport. In particular, the authors uncover evidence of two “”blocking”” mechanisms in 1,2,3-triazole, where covalent and hydrogen bonds formed by the central nitrogen atom limit the mobility of protons. The authors’ simulations thus provide insights into the origins of the exptl. observed 10-fold difference in proton conductivity After reading the article, we found that the author used 1H-1,2,3-Triazole(cas: 288-36-8Quality Control of 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Quality Control of 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 1H-1,2,3-TriazoleIn 2021 ,《1,2,3-Triazole hybrids with anti-HIV-1 activity》 appeared in Archiv der Pharmazie (Weinheim, Germany). The author of the article were Feng, Lian-Shun; Zheng, Man-Jie; Zhao, Feng; Liu, Duan. The article conveys some information:

A review. The human immunodeficiency virus type 1 (HIV-1) is the major etiol. agent responsible for the acquired immunodeficiency syndrome (AIDS), which is a serious infectious disease and remains one of the most prevalent problems at present. Currently, combined antiretroviral therapy is the primary modality for the treatment and management of HIV/AIDS, but the long-term use can result in major drawbacks such as the development of multidrug-resistant viruses and multiple side effects. 1,2,3-Triazole is the common framework in the development of new drugs, and its derivatives have the potential to inhibit various HIV-1 enzymes such as reverse transcriptase, integrase, and protease, consequently possessing a potential anti-HIV-1 activity. This review covers the recent advances regarding the 1,2,3-triazole hybrids with potential anti-HIV-1 activity; it focuses on the chem. structures, structure-activity relationship, and mechanisms of action, covering articles published from 2010 to 2020. In the experiment, the researchers used many compounds, for example, 1H-1,2,3-Triazole(cas: 288-36-8Recommanded Product: 1H-1,2,3-Triazole)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Recommanded Product: 1H-1,2,3-Triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《A fast and simple SPE-LC-MS/MS procedure for extraction and quantitative analysis of 1,2,4-triazole, N,N-dimethylsulfamide, and other small polar organic compounds in groundwater》 was written by Bollmann, Ulla E.; Badawi, Nora. Application of 288-36-8This research focused ontriazole dimethylsulfamide organic compound groundwater; ENVI-Carb; Hypercarb; LC-MS/MS; PMOCs; SPE; Solid phase extraction. The article conveys some information:

Small polar organic pollutants have been discovered to be great threats to the groundwater, as they often are highly mobile and persistent in the environment. 1,2,4-Triazole and N,N-dimethylsulfamide, two well-known examples of small polar compounds, are frequent pollutants of upper groundwater. Both are degradation products of several fungicides commonly or previously used in agriculture, but also in wood-preserving paints. A common trait in the anal. of these small polar compounds is the lack of sufficient pre-concentration methods to lower the limit of detection and enable quant. anal. at nano-scale concentrations To date, they are analyzed only by direct injection in HPLC-MS/MS, with detection limits just below the European threshold value for pesticides in groundwater of 0.1μg/L. Based on a comprehensive method development, a solid phase extraction method was developed. As known LC methods for anal. of 1,2,4-triazole are based on Thermo Fisher’s Hypercarb column, emphasis was placed on testing various carbon-based materials. The final, thoroughly validated extraction protocol is based on Supelco’s ENVI-Carb Plus cartridges. With extraction recoveries close to 100% for 1,2,4-triazole and N,N-dimethylsulfamide and quantification limits of around 0.003μg/L, the method enables extraction and quantification of polar pollutants at nano-scale concentration from groundwater samples. In addition, the method is very promising to be used for other small polar pollutants. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《CASPT2, CASSCF and non-adiabatic molecular dynamics (NAMD) studies on the low-lying electronic states of 1H-1,2,3-triazole photolysis》 was written by Gil, Eduarda Sangiogo; de Araujo, Bruno Bercini; Goncalves, Paulo F. B.. SDS of cas: 288-36-8This research focused ontriazole photolysis mechanism oscillator strength triplet state absorption spectra. The article conveys some information:

The photolysis mechanisms of 1H-1,2,3-triazole and 1H-1,2,3-benzotriazole were elucidated by employing multiconfigurational methods (CASSCF and CASPT2). The potential energy curves and crossing points for the low-lying excited states were analyzed. In addition to the static electronic structure calculations, non-adiabatic mol. dynamics (NAMD) was propagated at the CASSCF level using SHARC (Surface Hopping including ARbitrary Couplings) dynamics in order to verify the proposed static picture, thereby understanding the possible reaction paths and the time scale of the photo-induced events. The S1 state for 1H-1,2,3-triazole reached a conical intersection between the S0 and S1 surfaces on a time scale of 100 fs. The emerging picture of the reaction presented here is the rupture of the triazole ring in the S1 state and the relaxation through a conical intersection to the S0. On the S0 surface, the triazoles easily extrude N2 and then undergo the hetero-Wolff rearrangement forming ethanimine.1H-1,2,3-Triazole(cas: 288-36-8SDS of cas: 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties SDS of cas: 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Jiu, Alexander Y.; Slocumb, Hannah S.; Yeung, Charles S.; Yang, Xiao-Hui; Dong, Vy M. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Addition of Pyrazoles to Dienes》.Application of 288-36-8 The article contains the following contents:

We report the first enantioselective addition of pyrazoles to 1,3-dienes [e.g., 1H-pyrazole + (E)-1-phenyl-1,3-butadiene → I (91%, 96:4 er)]. Secondary and tertiary allylic pyrazoles can be generated with excellent regioselectivity. Mechanistic studies support a pathway distinct from previous hydroaminations: a Pd0-catalyzed ligand-to-ligand hydrogen transfer (LLHT). This hydroamination tolerates a range of functional groups and advances the field of diene hydrofunctionalization.1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Taming Ambident Triazole Anions: Regioselective Ion Pairing Catalyzes Direct N-Alkylation with Atypical Regioselectivity》 was written by Dale, Harvey J. A.; Hodges, George R.; Lloyd-Jones, Guy C.. COA of Formula: C2H3N3This research focused ontriazole regioselective alkylation organocatalysis ion pairing. The article conveys some information:

Controlling the regioselectivity of ambident nucleophiles toward alkylating agents is a fundamental problem in heterocyclic chem. Unsubstituted triazoles are particularly challenging, often requiring inefficient stepwise protection-deprotection strategies and prefunctionalization protocols. Herein we report on the alkylation of archetypal ambident 1,2,4-triazole, 1,2,3-triazole, and their anions, analyzed by in situ 1H/19F NMR, kinetic modeling, diffusion-ordered NMR spectroscopy, X-ray crystallog., highly correlated coupled-cluster computations [CCSD(T)-F12, DF-LCCSD(T)-F12, DLPNO-CCSD(T)], and Marcus theory. The resulting mechanistic insights allow design of an organocatalytic methodol. for ambident control in the direct N-alkylation of unsubstituted triazole anions. Amidinium and guanidinium receptors are shown to act as strongly coordinating phase-transfer organocatalysts, shuttling triazolate anions into solution The intimate ion pairs formed in solution retain the reactivity of liberated triazole anions but, by virtue of highly regioselective ion pairing, exhibit alkylation selectivities that are completely inverted (1,2,4-triazole) or substantially enhanced (1,2,3-triazole) compared to the parent anions. The methodol. allows direct access to 4-alkyl-1,2,4-triazoles (rr up to 94:6) and 1-alkyl-1,2,3-triazoles (rr up to 99:1) in one step. Regioselective ion pairing acts in effect as a noncovalent in situ protection mechanism, a concept that may have broader application in the control of ambident systems. In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8COA of Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties COA of Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《ZINClick v.18: Expanding Chemical Space of 1,2,3-Triazoles》 was written by Levre, Doriana; Arcisto, Chiara; Mercalli, Valentina; Massarotti, Alberto. Formula: C2H3N3This research focused onZINClick database triazole alkyne azide. The article conveys some information:

In the last years, we have investigated the click-chem. space covered by mols. containing the triazole ring and generated a database of 1,2,3-triazoles called ZINClick, starting from literature-reported alkynes and azides synthesizable in no more than three synthetic steps from com. available products. This combinatorial database contains millions of 1,4-disubstituted 1,2,3-triazoles that are easily synthesizable. The library is regularly updated and can be freely downloaded from http://www.ZINClick.organic In this communication, the new implementation of ZINClick will be discussed as well as our new strategy for clustering the chem. space covered by 1,4-disubstituted 1,2,3-triazoles around their availability: from direct purchase to different degrees of synthetic feasibility of the compounds In the part of experimental materials, we found many familiar compounds, such as 1H-1,2,3-Triazole(cas: 288-36-8Formula: C2H3N3)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Formula: C2H3N3

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Nucleophilic Aromatic Substitution of Unactivated Fluoroarenes Enabled by Organic Photoredox Catalysis》 was written by Pistritto, Vincent A.; Schutzbach-Horton, Megan E.; Nicewicz, David A.. Related Products of 288-36-8 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Nucleophilic aromatic substitution (SNAr) is a classical reaction with well-known reactivity toward electron-poor fluoroarenes. However, electron-neutral and electron-rich fluoro(hetero)arenes are considerably underrepresented. Herein, we present a method for the nucleophilic defluorination of unactivated fluoroarenes enabled by cation radical-accelerated nucleophilic aromatic substitution. The use of organic photoredox catalysis renders this method operationally simple under mild conditions and is amenable to various nucleophile classes, including azoles, amines, and carboxylic acids. Select fluorinated heterocycles can be functionalized using this method. In addition, the late-stage functionalization of pharmaceuticals is also presented. Computational studies demonstrate that the site selectivity of the reaction is dictated by arene electronics. In addition to this study using 1H-1,2,3-Triazole, there are many other studies that have used 1H-1,2,3-Triazole(cas: 288-36-8Related Products of 288-36-8) was used in this study.

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Related Products of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Marshall, Checkers R.; Dvorak, Josh P.; Twight, Liam P.; Chen, Lan; Kadota, Kentaro; Andreeva, Anastasia B.; Overland, Alexandra E.; Ericson, Thomas; Cozzolino, Anthony F.; Brozek, Carl K. published an article in Journal of the American Chemical Society. The title of the article was 《Size-Dependent Properties of Solution-Processable Conductive MOF Nanocrystals》.Application of 288-36-8 The author mentioned the following in the article:

The diverse optical, magnetic, and electronic behaviors of most colloidal semiconductor nanocrystals emerge from materials with limited structural and elemental compositions Conductive metal-organic frameworks (MOFs) possess rich compositions with complex architectures but remain unexplored as nanocrystals, hindering their incorporation into scalable devices. Here, we report the controllable synthesis of conductive MOF nanoparticles based on Fe(1,2,3-triazolate)2. Sizes can be tuned to as small as 5.5 nm, ensuring indefinite colloidal stability. These solution-processable MOFs can be analyzed by solution-state spectroscopy and electrochem. and cast into conductive thin films with excellent uniformity. This unprecedented anal. of MOF materials reveals a strong size dependence in optical and electronic behaviors sensitive to the intrinsic porosity and guest-host interactions of MOFs. These results provide a radical departure from typical MOF characterization, enabling insights into phys. properties otherwise impossible with bulk analogs while offering a roadmap for the future of MOF nanoparticle synthesis and device fabrication. The experimental part of the paper was very detailed, including the reaction process of 1H-1,2,3-Triazole(cas: 288-36-8Application of 288-36-8)

1H-1,2,3-Triazole(cas: 288-36-8) belongs to triazoles. Triazoles are an important group of nitrogen-containing five-membered heterocyclic scaffolds. Triazoles are core structures of several drugs and pharmaceutical agents. Triazole derivatives possess antimicrobial, antiparasitic, antidiabetic, analgesic, and anti-inflammatory properties Application of 288-36-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics