Tag: 100-200

On March 3, 2010, Grimster, Neil; Zhang, Li; Fokin, Valery V. published an article.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Synthesis and Reactivity of Rhodium(II) N-Triflyl Azavinyl Carbenes. And the article contained the following:

Highly reactive rhodium(II) N-trifluoromethylsulfonyl azavinyl carbenes are formed in situ from NH-1,2,3-triazoles, triflic anhydride, and rhodium carboxylates. They rapidly and selectively react with olefins, providing cyclopropane carboxaldehydes and 2,3-dihydropyrroles in generally excellent yields and high enantio- and diastereoselectivity. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole triflic anhydride chiral rhodium carboxylate catalyst, rhodium azavinyl carbene triflyl derivative formation alkene cyclopropanation, cyclopropane carboxaldehyde stereoselective preparation, alkene rhodium triflyl azavinyl carbene dipolar cycloaddition, dihydropyrrole derivative regioselective preparation and other aspects.Reference of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Vorona, Svetlana V.; Zevatskii, Yuri E.; Myznikov, Leonid V. published an article in 2019, the title of the article was Zinc (II) Chloride as Phase Transfer Catalyst and as Catalyst of Cycloaddition Azide Ion to Heterocumulenes and Terminal Alkynes in Organic Solvents.Name: 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

The system of NaN3-ZnCl2 in organic solvents was effective for azide ion cycloaddition to heterocumulenes and terminal alkynes. The reaction proceeded readily in the case of heterocumulenes, so these transformations fall into the category of click reactions. The study on the reaction mechanism showed that role of zinc salt consists in transferring azide ion to the organic phase and decreasing the energy barrier of nucleophilic addition of azide ion to the unsaturated substrate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to isothiocyanate sodium azide zinc chloride catalyst cycloaddition, thiotetrazole preparation, carbodiimide sodium azide zinc chloride catalyst cycloaddition, aminotetrazole preparation, terminal alkyne sodium azide zinc chloride catalyst regioselective cycloaddition, triazole preparation and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On January 19, 2018, Bhagat, Ujjawal Kumar; Peddinti, Rama Krishna published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Asymmetric Organocatalytic Approach to 2,4-Disubstituted 1,2,3-Triazoles by N2-Selective Aza-Michael Addition. And the article contained the following:

Cycloalkenones (2-cyclohexen-1-one, 4,4-dimethyl-2-cyclohexen-1-one, 2-cyclopenten-1-one) underwent regio- and enantioselective aza-Michael reactions with aryl-1,2,3-triazoles in the presence of a nonracemic cinchonine-derived thiourea to yield nonracemic (oxocycloalkyl)aryltriazoles I [R = Ph, 3-MeOC6H4, 4-MeOC6H4, 4-MeC6H4, 4-i-PrC6H4, 2-ClC6H4, 4-ClC6H4, 2-O2NC6H4, 3-O2NC6H4, 2-BrC6H4, 4-BrC6H4, 2,5-(MeO)2C6H3, 3,4-(MeO)2C6H3, 2,3-Cl2C63, 2,4,5-(MeO)3C6H2, 2-methoxy-1-naphthyl; X = CH2, CMe2, bond] in 58-75% yields and in 44->99% ee (with 0-25% yields of regioisomeric products derived from N1-addition). The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to oxocycloalkyl aryltriazole regioselective enantioselective preparation, regioselective enantioselective aza michael addition aryltriazole cycloalkenone cinchonine thiourea, cinchonine thiourea catalyst regioselective enantioselective michael addition aryltriazole cycloalkenone and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Park, Gab-Man; Park, Hyun; Oh, Sangtae; Lee, Seokjoon published an article in 2017, the title of the article was Antimalarial activity of C-10 substituted triazolyl artemisinin.Computed Properties of 5301-96-2 And the article contains the following content:

Synthesis of C-10 substituted triazolyl artemisinins I [R = Ph, 4-MeC6H4, 3-ClC6H4, etc.], II and III [R = 4-Ph, 5-Ph, 5-(4-MeC6H4), 5-(3-ClC6H4), etc.] by the Huisgen cycloaddition reaction between dihydroartemisinins and variously substituted 1,2,3-triazoles was described. The antimalarial activities of 32 novel artemisinin derivatives I , II and III were screened against a chloroquine-resistant parasite. Among them, triazolyl artemisinins with electron-withdrawing groups showed stronger antimalarial activities than those shown by the derivatives having electron-donating groups. In particularly, m-chlorotriazolyl artemisinin I [R = 3-ClC6H4], II [R = 3-ClC6H4] and III [R = 5-(3-ClC6H4), 4-(3-ClC6H4)] showed antimalarial activity equivalent to that of artemisinin and could be a strong drug candidate. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Computed Properties of 5301-96-2

The Article related to substituted triazolyl artemisinin preparation regioselective diastereoselective antimalarial human, dihydroartemisinin triazole huisgen cycloaddition, antimalarial activity, artemisinin, dihydroartemisinin, substituted triazolyl artemisinin, synthesis and other aspects.Computed Properties of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On August 20, 2021, Wang, Tao; Tang, Zongyuan; Luo, Han; Tian, Yi; Xu, Mingchuan; Lu, Qixing; Li, Baosheng published an article.HPLC of Formula: 5301-96-2 The title of the article was Access to (Z)-β-Substituted Enamides from N1-H-1,2,3-Triazoles. And the article contained the following:

A direct ring-opening/nucleophilic substitution reaction of N1-H-1,2,3-triazoles was described. Divergent (Z)-β-halogen- or sulfonyl-substituted enamides were stereospecifically synthesized in a tunable manner. This strategy might not only enable a new ring-opening method of N1-H-1,2,3-triazoles under non-metal catalysis and mild reaction conditions but also offer a good opportunity to reliably access versatile (Z)-β-substituted enamides that could be used as synthetic precursors for further synthetic transformations. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).HPLC of Formula: 5301-96-2

The Article related to acyl halide triazole tandem diastereoselective ring opening nucleophilic substitition, halovinyl amide preparation, sulfonate acyl chloride triazole multicomponent tandem ring opening substitition, amido vinylsulfonate preparation diastereoselective and other aspects.HPLC of Formula: 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 5, 2021, Hazarika, Roktopol; Garg, Anirban; Chetia, Swadhin; Phukan, Parmita; Kulshrestha, Akshay; Kumar, Arvind; Bordoloi, Ankur; Kalita, Amlan Jyoti; Guha, Ankur Kanti; Sarma, Diganta published an article.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Magnetically separable ZnFe2O4 nanoparticles: a low cost and sustainable catalyst for propargyl amine and NH-triazole synthesis. And the article contained the following:

The multicomponent reaction (MCR) strategy for the construction of important mol. scaffolds is in trending nowadays and among them, A3-coupling stands in a significant position. Aldehyde, amine and alkynes are coupled in this particular reaction via C-H activation process. Herein, zinc ferrite nanoparticles are reported as magnetically separable heterogeneous catalyst for A3-coupling reaction with attractive attributes like excellent productivity, selectivity and better reusability. Moreover, the catalyst can also be effectively applied for the synthesis of various NH-triazoles in quant. yields. A plausible mechanism has been proposed for the synthesis of NH-triazoles followed by validation with computational study. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to triazole preparation, magnetically separable zinc ferrite nanoparticle preparation multicomponent catalyst, aldehyde amine alkyne coupling zinc ferrite, nitromethane aldehyde sodium azide coupling zinc ferrite, propargyl amine preparation and other aspects.Recommanded Product: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Yan, Wuming; Liao, Tao; Tuguldur, Odbadrakh; Zhong, Cheng; Petersen, Jeffrey L.; Shi, Xiaodong published an article in 2011, the title of the article was Mitsunobu Reaction of 1,2,3-NH-Triazoles: A Regio- and Stereoselective Approach to Functionalized Triazole Derivatives.Synthetic Route of 5301-96-2 And the article contains the following content:

Mitsunobu reactions of primary, secondary, benzylic and allylic alcs. with 1,2,3-triazoles and 1,2,3-benzotriazole gave the N2-alkylated triazoles and benzotriazoles in most cases as the major regioisomers; N-alkylation reactions also occurred with high stereoselectivities when either trans-2-methyl-1-cycloalkanols or nonracemic alcs. were used as electrophiles. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Synthetic Route of 5301-96-2

The Article related to alkyl allylic benzylic triazole regioselective stereoselective preparation, regioselective mitsunobu reaction triazole benzotriazole alc, stereoselective regioselective mitsunobu reaction benzotriazole nonracemic alc methylcycloalkanol and other aspects.Synthetic Route of 5301-96-2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On October 6, 2017, Zhang, Lingling; Yi, Hong; Wang, Jue; Lei, Aiwen published an article.Name: 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was Visible-Light Mediated Oxidative C-H/N-H Cross-Coupling between Tetrahydrofuran and Azoles Using Air. And the article contained the following:

THF is a privileged structural moiety in many important organic compounds In this work, a simple and mild catalytic oxidative amination of THF mediated by visible-light catalysis was developed. The C(sp3)-H bond of THF was activated using mol. oxygen as a benign oxidant. Besides, a variety of azoles could be tolerated, providing a green route for N-substituted azoles, e.g., I. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Name: 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole thf oxidative cross coupling amination light blue led, thf azole hybrid preparation, visible light oxidative amination mediator, methyltriphenyl acridinium perchlorate oxidative cross coupling amination photocatalyst and other aspects.Name: 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Wan, Zhaohua; Wang, Dan; Yang, Zixuan; Zhang, Heng; Wang, Shengchun; Lei, Aiwen published an article in 2020, the title of the article was Electrochemical oxidative C(sp3)-H azolation of lactams under mild conditions.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole And the article contains the following content:

An electrochem. oxidative direct C(sp3)-H azolation of lactams was reported under metal catalyst-free and external chem. oxidant-free conditions. This electrochem. C(sp3)-H/N-H coupling was characterized by its broad substrate scope of azoles and lactams under mild conditions at room temperature Mechanistic studies suggested that the reaction possibly involves a radical process. Moreover, the site selectivity was explained by DFT calculations More meaningfully, a gram-scale synthesis method of flow electrochem. was employed to show the scaled-up applicability of this transformation. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to azole lactam electrochem oxidative azolation, azolyl lactam preparation, amide azole electrochem oxidative azolation, amido azole preparation, pyrazole urea electrochem oxidative azolation, pyrazolyl urea preparation and other aspects.Application In Synthesis of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

On September 30, 2022, Sandeep, K.; Sanjeeva Kumar, A.; Qureshi, Asif Ali; Kumara Swamy, K. C. published an article.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole The title of the article was (3+2) Cycloadditions of Vinyl Sulfonyl Fluorides with Ethyl Diazoacetate or Azides: Metal-Free Synthesis of Pyrazole and Triazole Scaffolds via SO2 Elimination. And the article contained the following:

A (3 +2) cycloaddition reaction between substituted vinyl sulfonyl fluorides RCH=CHS(O)2F (R = Ph, 2,4,6-trimethylphenyl, naphthalen-2-yl, etc.) and 3,4-dihydronaphthalene-2-sulfonyl fluoride and Et diazoacetate or azides R1N3 (R1 = Ph, Bn, 4-nitrophenyl, etc.) for the rapid construction of pyrazole I or triazole cores II (R1 = H, Ph, Bn, 4-nitrophenyl, etc.) via Michael addition and SO2 gas elimination is developed. Trimethylsilyl azide or organic azide selectively attacks at the β-carbon of vinyl sulfonyl fluoride rather than at the S(VI) center and generates C-substituted or C,N-disubstituted triazole II. In contrast, vinyl sulfonyl fluorides react with Et diazoacetate to generate pyrazoles I in good to high yields. The experimental process involved the reaction of 4-(p-Tolyl)-1H-1,2,3-triazole(cas: 5301-96-2).Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

The Article related to pyrazole preparation chemoselective, ethyl diazoacetate vinyl sulfonyl fluoride cycloaddition michael addition, triazole preparation chemoselective, azide vinyl sulfonyl fluoride cycloaddition michael addition and other aspects.Quality Control of 4-(p-Tolyl)-1H-1,2,3-triazole

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics