Tag: 500-600

Microparticle Matrix Encoding of Beads was written by Meldal, Morten;Christensen, Soeren Flygering. And the article was included in Angewandte Chemie, International Edition in 2010.Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

The authors present a versatile, simple encoding principle that may solve many problems in solid-phase screening and decoding: optical microparticle matrix encoding (MPM encoding) with fluorescent microparticles. The utility of this technique has been demonstrated in the identification of avidin ligands from a focused library, in which compounds could not be distinguished with mass spectrometric methods. The library design was based upon previously reported L– and D-amino acid libraries for avidin and streptavidin, thus indicating selectivity for aromatic residues. Uniform 10 μm Tentagel microparticles labeled with a chem. stable fluorophore ATOTA [tris(dialkylamino)trioxatriangulenium ion] were randomly distributed in a bis(acrylamido)polyethylene glycol (PEG) macromonomer (64,000 cm^-3) by ultrasound and homogenization. Inverse suspension polymerization of the microparticle-containing macromonomer in the presence of bis(tert-butyldiphenylmethylsilyl)PEG1500 stabilizer provided 500,000 uniform, amino-functionalized, uniquely encoded beads (72 mL; ca 6.5 g dry weight), which contained an average of 8 microparticles per bead, with a bead size of (550±100) μm. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Application In Synthesis of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Modulating Oxytocin Activity and Plasma Stability by Disulfide Bond Engineering was written by Muttenthaler, Markus;Andersson, Asa;de Araujo, Aline D.;Dekan, Zoltan;Lewis, Richard J.;Alewood, Paul F.. And the article was included in Journal of Medicinal Chemistry in 2010.Recommanded Product: 156311-83-0 The following contents are mentioned in the article:

Disulfide bond engineering is an important approach to improve the metabolic half-life of cysteine-containing peptides. Eleven analogs of oxytocin were synthesized including disulfide bond replacements by thioether, selenylsulfide, diselenide, and ditelluride bridges, and their stabilities in human plasma and activity at the human oxytocin receptor were assessed. The cystathionine (K_i = 1.5 nM, and EC₅₀ = 32 nM), selenylsulfide (K_i = 0.29/0.72 nM, and EC₅₀ = 2.6/154 nM), diselenide (K_i = 11.8 nM, and EC₅₀ = 18 nM), and ditelluride analogs (K_i = 7.6 nM, and EC₅₀ = 27.3 nM) retained considerable affinity and functional potency as compared to oxytocin (K_i = 0.79 nM, and EC₅₀ = 15 nM), while shortening the disulfide bridge abolished binding and functional activity. The mimetics showed a 1.5-3-fold enhancement of plasma stability as compared to oxytocin (t_1/2 = 12 h). By contrast, the all-D-oxytocin and head to tail cyclic oxytocin analogs, while significantly more stable with half-lives greater than 48 h, had little or no detectable binding or functional activity. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles exhibit substantial isomerism, depending on the positioning of the nitrogen atoms within the ring. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Recommanded Product: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Methylamidation for Sialoglycomics by MALDI-MS: A Facile Derivatization Strategy for Both α2,3- and α2,6-Linked Sialic Acids was written by Liu, Xin;Qiu, Hongyu;Lee, Rhonda Kuo;Chen, Wangxue;Li, Jianjun. And the article was included in Analytical Chemistry (Washington, DC, United States) in 2010.Synthetic Route of C17H27F6N7OP2 The following contents are mentioned in the article:

Neutralization of carboxylic acid is an important means to avoid sialic acid dissociation when sialylated glycans are analyzed by matrix-assisted laser desorption ionization mass spectrometry (MALDI-MS). In this paper, the authors describe a simple and rapid method to modify the sialic acids of sialylated glycans in the presence of methylamine and (7-azabenzotriazol-1-yloxy)trispyrrolidinophosphonium hexafluorophosphate (PyAOP). After methylamidation, sialylated glycans can be analyzed by MALDI-MS without loss of the sialic acid moiety. The electrospray ionization mass spectrometry (ESI-MS) and MALDI-MS anal. of both 3′- and 6′-sialyllactose derivatives indicated that the quant. conversion of sialic acids was achieved, regardless of their linkage types. This derivatization strategy was further validated with the N-glycans released from three standard glycoproteins (fetuin, human acid glycoprotein, and bovine acid glycoprotein) containing different types of complex glycans. Most importantly, this derivatization method enabled the successful characterization of N-glycans of sera from different species (human, mouse, and rat) by MALDI-MS. Because of the mild reaction conditions, the modification in sialic acid residues can be retained. This improvement makes it possible to detect sialylated glycans containing O-acetylated sialic acid moieties using MALDI-MS in pos.-ion mode. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Synthetic Route of C17H27F6N7OP2).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeSynthetic Route of C17H27F6N7OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

PyClocK, the phosphonium salt derived from 6-Cl-HOBt was written by Subiros-Funosas, Ramon;Moreno, Juan A.;Bayo-Puxan, Nuria;Abu-Rabeah, Khalil;Ewenson, Ariel;Atias, Danit;Marks, Robert S.;Albericio, Fernando. And the article was included in Chimica Oggi in 2008.Category: triazoles The following contents are mentioned in the article:

Novel phoshphonium salts of benzotriazoles, which are highly reactive coupling agents, and are particularly useful in peptide synthesis, are described. Further described is a process of preparing the novel phosphonium salts and methods for preparing peptides. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Category: triazoles).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. The presence of the three nitrogen atoms in triazole structures afforded opportunities for a plethora of structural modification with the generation of novel therapeutically potential agents, which is different from other heterocyclic compounds.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Novel coupling method for the incorporation of ‘complex’ amino acid was written by Garcia-Martin, Fayna;Hinou, Hiroshi;Matsushita, Takahiko;Nishimura, Shin-ichiro. And the article was included in Peptide Science in 2010.Recommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

A symposium report. Novel coupling method for glycosylated amino acids (models for “complex” amino acids) relies on the synergy of microwave energy, incorporation of only 1.2 equiv of amino acid, PEG-containing resins and “double-activation” method. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeRecommanded Product: ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Racemization studies during solid-phase peptide synthesis using azabenzotriazole-based coupling reagents was written by Carpino, Louis A.;El-Faham, Ayman;Albericio, ernando. And the article was included in Tetrahedron Letters in 1994.Electric Literature of C17H27F6N7OP2 The following contents are mentioned in the article:

1-Hydroxy-7-azabenzotriazole (HOAt) (I) and its corresponding uronium salts are more effective in avoiding racemization in a model solid-phase peptide segment coupling process than their benzotriazole analogs. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Electric Literature of C17H27F6N7OP2).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeElectric Literature of C17H27F6N7OP2

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

N-acylation in combinatorial chemistry was written by Katritzky, Alan R.;Suzuki, Kazuyuki;Singh, Sandeep K.. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2004.Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) The following contents are mentioned in the article:

A review. Polymer-supported N-acylation utilizing carbodiimides with additives, direct coupling reagents (phosphonium salts and uronium salts), N-acylazoles, and other reagents are discussed. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. The triazole ring is a relatively stable functional group, and the triazole bond can be used for a variety of applications, such as replacing the phosphate backbone of DNA.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Safety of ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V)

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthesis of the C-terminal pentapeptide of the peptaibol culicinins was written by Zhang, Wei;Sun, Tian-Tian;Li, Ying-Xia. And the article was included in Journal of Peptide Science in 2009.Recommanded Product: 156311-83-0 The following contents are mentioned in the article:

The synthesis of the C-terminal pentapeptide of culicinins has been achieved using [4 + 1] protocol and reduction-coupling strategy. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Recommanded Product: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Many triazoles are versatile, biologically active compounds commonly used as fungicides and plant retardants.Triazole heterocyclic structures are found to form many weak nonbond interactions with the receptors and enzymes in biological systems.Recommanded Product: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Reaction microarrays: a method for rapidly determining the enantiomeric excess of thousands of samples was written by Gibertson, Scott R.. And the article was included in Chemtracts in 2001.SDS of cas: 156311-83-0 The following contents are mentioned in the article:

The title research (of G. A. Gorber, et al., 2001) is reviewed with commentary and 21 references This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0SDS of cas: 156311-83-0).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles consist of a five-membered ring containing three nitrogen atoms and are biologically active, especially as antifungal, antimicrobial and enzyme inhibitors. Triazole growth retardants such as uniconazole and paclobutrazol have been known to inhibit the biosynthesis of gibberellins by blocking kaurene oxidase, an P450 enzymeSDS of cas: 156311-83-0

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Total synthesis of halipeptins A and D and analogues was written by Nicolaou, K. C.;Kim, David W.;Schlawe, Daniel;Lizos, Dimitrios E.;de Noronha, Rita G.;Longbottom, Deborah A.. And the article was included in Angewandte Chemie, International Edition in 2005.Category: triazoles The following contents are mentioned in the article:

Deceptive rings: Halipeptins A I (R² = CH₂OH) and D I (R² = Me) and analogs thereof were synthesized from azide fragment II and ester fragment III (R = OSiPh₂CMe₃, H, resp.). Key steps included peptide-bond formation, DAST-induced thiazoline construction, and macrolactamization. Unlike the naturally isolated (and possibly contaminated) material, synthetic halipeptin D exhibited only weak toxicity against tumor cells. This study involved multiple reactions and reactants, such as ((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0Category: triazoles).

((3H-[1,2,3]Triazolo[4,5-b]pyridin-3-yl)oxy)tri(pyrrolidin-1-yl)phosphonium hexafluorophosphate(V) (cas: 156311-83-0) belongs to triazole derivatives. Triazoles are important five-member nitrogen heterocycles involved in a wide range of industrial applications such as agrochemicals, corrosion inhibitors, dyes, optical brighteners, as well as biologically active agents. 1,2,3-Triazoles are usually prepared following (3+2) cycloaddition protocols. A common technique for unsubstituted triazoles is the Huisgen azide-alkyne 1,3-dipolar cycloaddition: a azide and an alkyne react at high temperature to form a ring. However, the Huisgen strategy produces a mixture of isomers (typically 1,4- and 1,5-disubstituted) when used to produce substituted triazoles.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics