Tag: 500-600

In 2018,Shaw, Scott K.; Liu, Wenqi; Gomez Duran, Cesar Fernando Azael; Schreiber, Cynthia L.; de Lourdes Betancourt Mendiola, Maria; Zhai, Canjia; Roland, Felicia M.; Padanilam, Simon J.; Smith, Bradley D. published 《Non-Covalently Pre-Assembled High-Performance Near-Infrared Fluorescent Molecular Probes for Cancer Imaging》.Chemistry – A European Journal published the findings.Electric Literature of C30H30N10 The information in the text is summarized as follows:

New fluorescent mol. probes, which can selectively target specific cell surface receptors, are needed for microscopy, in vivo imaging, and image guided surgery. The preparation of multivalent probes using standard synthetic chem. can be a laborious process due to low reaction yields caused by steric effects. In this study, fluorescent mol. probes were prepared by a programmed non-covalent pre-assembly process that used a near-IR fluorescent squaraine dye to thread a macrocycle bearing a cyclic arginine-glycine-aspartate peptide antagonist (cRGDfK) as a cancer targeting unit. Cell microscopy studies using OVCAR-4 (ovarian cancer) and A549 (lung cancer) cells that express high levels of the integrin αvβ3 or αvβ5 receptors, resp., revealed a multivalent cell targeting effect. That is, there was comparatively more cell uptake of a pre-assembled probe equipped with two copies of the cRGDfK antagonist than a pre-assembled probe with only one appended cRGDfK antagonist. The remarkably high photostability and low phototoxicity of these near-IR probes allowed for acquisition of long-term fluorescence movies showing endosome trafficking in living cells. In vivo near-IR fluorescence imaging experiments compared the biodistribution of a targeted and untargeted probe in a xenograft mouse tumor model. The average tumor-to-muscle ratio for the pre-assembled targeted probe was 3.6 which matches the tumor targeting performance reported for analogous cRGDfK-based probes that were prepared entirely by covalent synthesis. The capability to excite these pre-assembled near-IR fluorescent probes with blue or deep-red excitation light makes it possible to determine if a target site is located superficially or buried in tissue, a probe performance feature that is likely to be very helpful for eventual applications such as fluorescence guided surgery. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Electric Literature of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Electric Literature of C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Keivanloo, Ali; Abbaspour, Sima; Sepehri, Saghi; Bakherad, Mohammad published an article in Polycyclic Aromatic Compounds. The title of the article was 《Synthesis, Antibacterial Activity and Molecular Docking Study of a Series of 1,3-Oxazole-Quinoxaline Amine Hybrids》.HPLC of Formula: 510758-28-8 The author mentioned the following in the article:

A series of 1,3-oxazole-quinoxaline amine hybrids I (R = -NHMe, -NHBn, morpholin-4-yl, etc.; X = H, Cl) were prepared successfully through a copper-free Sonogashira coupling followed by heteroannulation in a one-pot process. The reaction of benzoyl chlorides, prop-2-yn-1-amine, and 2-amine-substituted 3-chloroquinoxalines catalyzed by Pd(Ph3P)2Cl2 in the presence of tris(benzyltriazolylmethyl)amine (TBTA) as an efficient ligand in EtOH produced 1,3-oxazole-quinoxaline amine hybrids in high yields. All the synthesized 1,3-oxazole-quinoxaline amine hybrids were screened for antibacterial properties and were exposed to mol. docking studies. Mol. docking study manifested the possible binding mode of compounds with its bacterial target protein. The consequences of biol. activity and docking study disclosed that the increase of lipophilic and extra hydrogen bond characters are essential for suitable antibacterial activity. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8HPLC of Formula: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.HPLC of Formula: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《A Click Chemistry Strategy for the Synthesis of Efficient Photoinitiators for Two-Photon Polymerization》 was published in Advanced Functional Materials in 2020. These research results belong to Henning, Irene; Woodward, Adam W.; Rance, Graham A.; Paul, Benjamin T.; Wildman, Ricky D.; Irvine, Derek J.; Moore, Jonathan C.. Product Details of 510758-28-8 The article mentions the following:

It is reported that efficient photoinitiators, suitable for two-photon polymerization, can be obtained using the copper catalyzed azide/alkyne cycloaddition reaction. This click chem. strategy provides a modular approach to the assembly of photoinitiators that enables the rapid variation of key fragments to produce photoinitiators with desirable properties. To assess the performance of the first-in-class photoinitiators generated by this approach, a screening method is developed to enable the rapid determination of polymerization and damage thresholds in numerous photoresists during two-photon polymerization The degree of consumption of vinyl groups (DC) and homogeneity of the polymerization are further assessed by micro-Raman spectroscopy. Finally, more complex structures are fabricated to demonstrate that the efficient two-photon polymerization of stable 3D microarchitectures can be achieved using triazole-based photoinitiators. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Potent Metabolic Sialylation Inhibitors Based on C-5-Modified Fluorinated Sialic Acids》 were Heise, Torben; Pijnenborg, Johan F. A.; Buell, Christian; van Hilten, Niek; Kers-Rebel, Esther D.; Balneger, Natasja; Elferink, Hidde; Adema, Gosse J.; Boltje, Thomas J.. And the article was published in Journal of Medicinal Chemistry in 2019. Related Products of 510758-28-8 The author mentioned the following in the article:

Sialic acid sugars on mammalian cells regulate numerous biol. processes, while aberrant expression of sialic acid is associated with diseases such as cancer and pathogenic infection. Inhibition of the sialic acid biosynthesis may therefore hold considerable therapeutic potential. To effectively decrease the sialic acid expression, we synthesized C-5-modified 3-fluoro sialic acid sialyltransferase inhibitors. We found that C-5 carbamates significantly enhanced and prolonged the inhibitory activity in multiple mouse and human cell lines. As an underlying mechanism, we have identified that carbamate-modified 3-fluoro sialic acid inhibitors are more efficiently metabolized to their active cytidine monophosphate analogs, reaching higher effective inhibitor concentrations inside cells. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Expanding the Rubterolone Family: Intrinsic Reactivity and Directed Diversification of PKS-derived Pyrans》 was written by Guo, Huijuan; Benndorf, Rene; Koenig, Stefanie; Leichnitz, Daniel; Weigel, Christiane; Peschel, Gundela; Berthel, Patrick; Kaiser, Marcel; Steinbeck, Christoph; Werz, Oliver; Poulsen, Michael; Beemelmanns, Christine. Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineThis research focused ontropolone alkaloid biosynthesis antimicrobial cytotoxic antiinflammatory antiparasitic activity; biosynthetic pathway; chemical probes; natural products; polyketides; tropolone alkaloids. The article conveys some information:

We characterized two key biosynthetic intermediates of the intriguing rubterolone family (tropolone alkaloids) that contain a highly reactive pyran moiety (in equilibrium with the hydrolyzed 1,5-dione form) and undergo spontaneous pyridine formation in the presence of primary amines. We exploited the intrinsic reactivity of the pyran moiety and isolated several new rubterolone derivatives, two of which contain a unique thiazolidine moiety, e.g., I. Three rubterolone derivatives were chem. modified with fluorescence and biotin tags using peptide coupling and click reaction. Overall, eight derivatives were fully characterized by HRMS/MS and 1D and 2D NMR spectroscopy and their antimicrobial, cytotoxic, anti-inflammatory and antiparasitic activities evaluated. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 510758-28-8In 2022 ,《Anomeric DNA: Functionalization of α-D Anomers of 7-Deaza-2′-deoxyadenosine and 2′-Deoxyuridine with Clickable Side Chains and Click Adducts in Homochiral and Heterochiral Double Helices》 was published in Chemistry – A European Journal. The article was written by Zhang, Aigui; Leonard, Peter; Seela, Frank. The article contains the following contents:

Anomeric base pairs in heterochiral DNA with strands in the α-D and β-D configurations and homochiral DNA with both strands in α-D configuration were functionalized. The α-D anomers of 2′-deoxyuridine and 7-deaza-2′-deoxyadenosine were synthesized and functionalized with clickable octadiynyl side chains. Nucleosides were protected and converted to phosphoramidites. Solid-phase synthesis furnished 12-mer oligonucleotides, which were hybridized. Pyrene click adducts display fluorescence, a few of them with excimer emission. Tm values and thermodn. data revealed the following order of duplex stability α/α-D≫β/β-D≥α/β-D. CD spectra disclosed that conformational changes occur during hybridization. Functionalized DNAs were modeled and energy minimized. Clickable side chains and bulky click adducts are well accommodated in the grooves of anomeric DNA. The investigation shows for the first time that anomeric DNAs can be functionalized in the same way as canonical DNA for potential applications in nucleic acid chem., chem. biol., and DNA material science. The results came from multiple reactions, including the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《3D Printing of Supramolecular Polymers: Impact of Nanoparticles and Phase Separation on Printability》 was written by Rupp, Harald; Doehler, Diana; Hilgeroth, Philipp; Mahmood, Nasir; Beiner, Mario; Binder, Wolfgang H.. Category: triazolesThis research focused onthree dimensional printing supramol polymer nanoparticle; 3D printing; extrusion printing; melt rheology; supramolecular polymers. The article conveys some information:

3D printing of linear and three-arm star supramol. polymers with attached hydrogen bonds and their nanocomposites is reported. The concept is based on hydrogen-bonded supramol. polymers, known to form nano-sized micellar clusters. Printability is based on reversible thermal- and shear-induced dissociation of a supramol. polymer network, which generates stable and self-supported structures after printing, as checked via melt-rheol. and X-ray scattering. The linear and three-arm star poly(isobutylene)s PIB-B2 (Mn = 8500 g mol -1), PIB-B3 (Mn = 16 000 g mol -1), and linear poly(ethylene glycol)s PEG-B2 (Mn = 900 g mol-1, 8500 g mol -1) are prepared and then probed by melt-rheol. to adjust the viscosity to address the proper printing window. The supramol. PIB polymers show a rubber-like behavior and are able to form self-supported 3D printed objects at room temperature and below, reaching polymer strand diameters down to 200-300 μm. Nanocomposites of PIB-B2 with silica nanoparticles (12 nm, 5-15 wt%) are generated, in turn leading to an improvement of their shape persistence. A blend of the linear polymer PIB-B2 and the three-arm star polymer PIB-B3 (ratio ≈ 3/1 mol) reaches an even higher structural stability, able to build free-standing structures. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Category: triazoles) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: 510758-28-8In 2020 ,《Alkynylated and Dendronized 5-Aza-7-deazaguanine Nucleosides: Cross-Coupling with Tripropargylamine and Linear Alkynes, Click Functionalization, and Fluorescence of Pyrene Adducts》 was published in Journal of Organic Chemistry. The article was written by Kondhare, Dasharath; Zhang, Aigui; Leonard, Peter; Seela, Frank. The article contains the following contents:

The change of the recognition face of 5-aza-7-deazaguanine bridgehead nucleosides with respect to purine nucleosides permits the construction of new purine-purine or purine-pyrimidine base pairs in DNA and RNA. Clickable derivatives of 5-aza-7-deazaguanine were synthesized by introducing ethynyl, 1,7-octadiynyl, and tripropargylamino side chains in the 7-position of the 5-aza-7-deazapurine moiety by Sonogashira cross-coupling. Click reactions were performed with 1-azidomethylpyrene by the copper-catalyzed azide-alkyne cycloaddition The copper(I)-catalyzed click reaction on the tripropargylamino nucleoside was significantly faster and higher yielding than that for nucleosides carrying linear alkynyl chains. Also, this reaction could be performed with copper(II) as the catalyst. An autocatalyzed cycle was suggested in which the click product acts as a catalyst. Pyrene click adducts of linear alkynylated nucleosides showed pyrene monomer emission, while tripropargylamino adducts showed monomer and excimer fluorescence. The fluorescence intensities of the 5-aza-7-deazaguanine nucleosides were higher than those of their 7-deazaguanine counterparts. The reported clickable nucleosides can be utilized to functionalize or to cross-link monomeric nucleosides or DNA for diagnostic or imaging purposes and other applications in nucleic acid chem. and biotechnol. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

The author of 《Imaging of chemotherapy-induced acute cardiotoxicity with 18F-labeled lipophilic cations》 were McCluskey, Stuart P.; Haslop, Anna; Coello, Christopher; Gunn, Roger N.; Tate, Edward W.; Southworth, Richard; Plisson, Christophe; Long, Nicholas J.; Wells, Lisa A.. And the article was published in Journal of Nuclear Medicine in 2019. Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:

Many chemotherapy agents are toxic to the heart, such that increasing numbers of cancer survivors are now living with the potentially lethal cardiovascular consequences of their treatment. Earlier and more sensitive detection of chemotherapy-induced cardiotoxicity may allow improved treatment strategies and increase long-term survival. Lipophilic cation PET tracers may be suitable for early detection of cardiotoxicity. This study aimed to evaluate an 18F-labeled lipophilic phosphonium cation, [1-(2-18F-fluoroethyl),1H[1,2,3]triazole-4-ethylene]triphenylphosphonium bromide (18F-MitoPhos), as a cardiac imaging agent, comparing it with leading PET and SPECT lipophilic cationic tracers before further assessing its potential for imaging cardiotoxicity in an acute doxorubicin model. Cardiac uptake and response to decreased mitochondrial membrane potential of 18F-MitoPhos and 99mTc-sestamibi were tested in isolated perfused rat hearts. Baseline pharmacokinetic profiles of 18F-MitoPhos and 18F-fluorobenzyltriphenylphosphonium and their response to acute doxorubicin-induced cardiotoxicity were assessed in rats in vivo (10, 15, or 20 mg of doxorubicin per kg, i.v., 48 h beforehand). Cardiac retention of 18F-MitoPhos was more than double that of 99mTc-sestamibi in isolated perfused rat hearts. A favorable biodistribution of 18F-MitoPhos in vivo was observed, with heart-to-tissue ratios of 304 ± 186, 11.2 ± 1.2, and 3.8 ± 0.6 for plasma, liver, and lung, resp. (60 min). A significant dose-dependent loss of cardiac retention of 18F-MitoPhos was observed on doxorubicin treatment, with average cardiac SUV from 30 to 60 min (mean ± SD) decreasing from 3.5 ± 0.5 (control) to 1.8 ± 0.1 (doxorubicin, 20 mg/kg). Other assessed biomarkers showed no alterations. 18F-MitoPhos showed pharmacokinetic parameters suitable for cardiac imaging. A significant dose response of cardiac uptake to doxorubicin treatment was observed before detectable biomarker alterations. 18F-MitoPhos is therefore a promising tracer for imaging chemotherapy-induced cardiotoxicity. To our knowledge, this is the first demonstration of radiolabeled lipophilic cations being used for the PET imaging of chemotherapy-induced cardiotoxicity and indicates the potential application of these compounds in this area. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Safety of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hadidi, Kaivin; Bellucci, Maria Cristina; Dall’Angelo, Sergio; Leeson-Payne, Alasdair; Rochford, Justin J.; Esko, Jeffery D.; Tor, Yitzhak; Volonterio, Alessandro published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Guanidinoneomycin-maleimide molecular transporter: synthesis, chemistry and cellular uptake》.Product Details of 510758-28-8 The article contains the following contents:

Guanidino-glycosides are a class of non-cytotoxic mol. transporters capable of delivering high mol. weight bioactive cargos into cells at low nanomolar concentrations Efficient bioconjugation with guanidinoglycosides has been previously demonstrated by utilizing a guanidinoneomycin decorated with a reactive but also unstable N-hydroxysuccinimmide ester-containing linker. Herein we report the synthesis, chem., and application of a new, stable guanidinoneomycin derivative armed with a highly specific maleimide moiety which allows for thiol-maleimide click chem., a highly popular bioconjugation strategy, widening the field of application of these intriguing and useful delivery vehicles. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Product Details of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Product Details of 510758-28-8Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics