Tag: 500-600

In 2018,Angewandte Chemie, International Edition included an article by Wagner, Nicolai; Stephan, Milena; Hoeglinger, Doris; Nadler, Andre. Electric Literature of C30H30N10. The article was titled 《A Click Cage: Organelle-Specific Uncaging of Lipid Messengers》. The information in the text is summarized as follows:

Lipid messengers exert their function on short time scales at distinct subcellular locations, yet most exptl. approaches for perturbing their levels trigger cell-wide concentration changes. Herein, we report on a coumarin-based photocaging group that can be modified with organelle-targeting moieties by click chem. and thus enables photorelease of lipid messengers in distinct organelles. We show that caged arachidonic acid and sphingosine derivatives can be selectively delivered to mitochondria, the ER, lysosomes, and the plasma membrane. By comparing the cellular calcium transients induced by localized uncaging of arachidonic acid and sphingosine, we show that the precise intracellular localization of the released second messenger is crucial for the signaling outcome. Ultimately, we anticipate that this new class of caged compounds will greatly facilitate the study of cellular processes on the organelle level. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Electric Literature of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Electric Literature of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Tan, Min; Wang, Xiaoying; Xie, Tong; Zhang, Zhen; Shi, Yi; Li, Yuanchao; Chen, Yongming published an article in Macromolecules (Washington, DC, United States). The title of the article was 《Fluorogenic Mechanophore Based on Dithiomaleimide with Dual Responsiveness》.Related Products of 510758-28-8 The author mentioned the following in the article:

The maleimide scaffold is widely used for the preparation of fluorogenic probes owing to its good fluorescence quenching ability. Here, we demonstrate that it can be also employed to prepare fluorogenic mechanophores. A dithiomaleimide-based mechanophore with two dansyl fluorophores attached to the maleimide core via the thioether bond is synthesized and incorporated into polymer chains. Upon mechanochem. activation, the relatively weak C-S is cleaved hypothetically due to its low bond dissociation energy, resulting in the removal of the maleimide conjugation and turning on of the dansyl fluorophore with >5-fold increase in the fluorescence emission peak intensity at 510 nm. In addition, an excess of a thiol can also lead to the cleavage of the dansyl fluorophore from the maleimide via thiol-exchange reactions. This mechanophore with dual responsiveness may have potential applications in stress sensing as well as thiol sensing. Moreover, the design concept of the mechanophore may allow access to many other fluorogenic mechanophores, since a number of fluorophores covering a wide range of emission wavelengths have been reported to be quenched by maleimides. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Evaluation of charge-regulated supramolecular copolymerization to tune the time scale for oxidative disassembly of β-sheet comonomers》 was written by Berac, Christian M.; Zengerling, Lydia; Strassburger, David; Otter, Ronja; Urschbach, Moritz; Besenius, Pol. Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine And the article was included in Macromolecular Rapid Communications in 2020. The article conveys some information:

A multistimuli-responsive supramol. copolymerization is reported. The copolymerization is driven by hydrogen bond encoded β-sheet-based charge co-assembly into 1D nanorods in water, using glutamic acid or lysine residues in either of the peptide comonomers. The incorporation of methionine as hydrophobic amino acid supports β-sheet formation, but oxidation of the thioether side-chain to a sulfoxide functional group destabilizes the β-sheet ordered domains and induces disassembly of the supramol. polymers. Using H2O2 as reactive oxygen species, the time scale and kinetics of the oxidative disassembly are probed. Compared to the charge neutral homopolymers, it is found that the oxidative disassembly of the charged ampholytic copolymers is up to two times faster and is operative at neutral pH. The strategy is therefore an important addition to the growing field of amphiphilic polythioether containing (macro)mol. building blocks, particularly in view of tuning their oxidation induced disassembly which tends to be notoriously slow and requires high concentrations of reactive oxygen species or acidic reaction media. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Design and Synthesis of Water-Soluble and Potent MMP-13 Inhibitors with Activity in Human Osteosarcoma Cells》 was written by Zapico, Jose Maria; Acosta, Lourdes; Pastor, Miryam; Rangasamy, Loganathan; Marquez-Cantudo, Laura; Coderch, Claire; Ortin, Irene; Nicolau-Sanus, Maria; Puchades-Carrasco, Leonor; Pineda-Lucena, Antonio; Majali-Martinez, Alejandro; Ramos, Pilar; de Pascual-Teresa, Beatriz; Ramos, Ana. Category: triazolesThis research focused onwater soluble MMP13 inhibitor activity human osteosarcoma cell; MMP-13 inhibitors; RMN; metalloproteinases; molecular modeling; organic synthesis; osteoarthritis. The article conveys some information:

Osteoarthritis is a degenerative disease, often resulting in chronic joint pain and commonly affecting elderly people. Current treatments with anti-inflammatory drugs are palliative, making the discovery of new treatments necessary. The inhibition of matrix metalloproteinase MMP-13 is a validated strategy to prevent the progression of this common joint disorder. We recently described polybrominated benzotriazole derivatives with nanomolar inhibitory activity and a promising selectivity profile against this collagenase. In this work, we have extended the study in order to explore the influence of bromine atoms and the nature of the S1′ heterocyclic interacting moiety on the solubility/selectivity balance of this type of compound Drug target interactions have been assessed through a combination of mol. modeling studies and NMR experiments Compound 9a has been identified as a water-soluble and highly potent inhibitor with activity in MG-63 human osteosarcoma cells.Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Category: triazoles) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Category: triazoles

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lorenzo, Emmaline R.; Olshansky, Jacob H.; Abia, Daniel S. D.; Krzyaniak, Matthew D.; Young, Ryan M.; Wasielewski, Michael R. published an article in 2021. The article was titled 《Interaction of Photogenerated Spin Qubit Pairs with a Third Electron Spin in DNA Hairpins》, and you may find the article in Journal of the American Chemical Society.Computed Properties of C30H30N10 The information in the text is summarized as follows:

The designing of tunable mol. systems that can host spin qubits is a promising strategy for advancing the development of quantum information science (QIS) applications. Photogenerated radical pairs are good spin qubit pair (SQP) candidates because they can be initialized in a pure quantum state that exhibits relatively long coherence times. DNA is a well-studied mol. system that allows for control of energetics and spatial specificity through careful design and thus serves as a tunable scaffold on which to control multispin interactions. Here, we examine a series of DNA hairpins that use naphthalenediimide (NDI) as the hairpin linker. Photoexcitation of the NDI leads to subnanosecond oxidation of guanine (G) within the duplex or a stilbenediether (Sd) end-cap to give NDI•–G•+ or NDI•–Sd•+ SQPs, resp. A 2,2,6,6-tetramethylpiperdinyl-1-oxyl (TEMPO) stable radical is covalently attached to the hairpin at varying distances from the SQP spins. While TEMPO has a minimal effect on the SQP formation and decay dynamics, EPR spectroscopy indicates that there are significant spin-spin dipolar interactions between the SQP and TEMPO. We also demonstrate the ability to implement more complex spin manipulations of the NDI•–Sd•+-TEMPO system using pulse-EPR techniques, which is important for developing DNA hairpins for QIS applications. In the experimental materials used by the author, we found Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Computed Properties of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Computed Properties of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

《Uniform Continuous and Segmented Nanofibers Containing a π-Conjugated Oligo(p-phenylene ethynylene) Core via “”Living”” Crystallization-Driven Self-Assembly: Importance of Oligo(p-phenylene ethynylene) Chain Length》 was written by Nie, Jiucheng; Wang, Zhiqin; Huang, Xiaoyu; Lu, Guolin; Feng, Chun. Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine And the article was included in Macromolecules (Washington, DC, United States) in 2020. The article conveys some information:

π-Conjugated nanofibers of controlled length and composition show promising potential applications from biomedicine to optoelectronics. However, efficient preparation of uniform nanofibers from π-conjugated polymers with precise control over length and composition poses an outstanding challenge. Herein, we report the synthesis of a suite of block copolymers (BCPs) containing π-conjugated crystalline oligo(p-phenylene ethynylene) (OPE) segments of different chain lengths and a poly(N-isopropylacrylamide) (PNIPAM) or a poly(2-vinylpyridine) (P2VP) block (OPE5-b-PNIPAM47, OPE7-b-PNIPAM47, OPE9-b-PNIPAM47, and OPE9-b-P2VP56; subscripts indicate the number of repeat units). The length of OPE segment significantly affected the self-assembly OPE-based BCPs. OPE5-b-PNIPAM47 chains were molecularly dissolved in ethanol. Although OPE7-b-PNIPAM47 formed fiber-like micelles of uniform width initially, these micelles were not frozen at room temperature (23°C), leading to the transformation from regular fiber-like micelles to irregular spherical aggregates upon aging for 7 days. Polydisperse fiber-like micelles of uniform width with kinetically frozen morphol. at 23°C were formed for OPE9-b-PNIPAM47 in ethanol by a direct heating-cooling cycle. The results were supported by the observations in dynamic light scattering, UV-vis, and fluorescence measurements, which indicated the resistance of OPE-based micelles toward micelle dissolution increased with the rising of OPE chain length. By the self-seeding approach of living crystallization-driven self-assembly (CDSA), uniform continuous micelles of controlled length (~40 nm-1.2μm) consisting of an OPE core and PNIPAM or P2VP shell can be obtained although micelles of OPE9-b-PNIPAM47 and OPE9-b-P2VP56 exhibited different resistance toward micelle dissolution Significantly, a series of uniform segmented OPE-based fiber-like comicelles and their hybrid nanostructures with excellent length and composition tunability can be achieved by the seeded growth approach of living CDSA. Overall, we provided a facile access to the fabrication of OPE-based nanofibers with precise control over their length and composition along with instructive information about the influence of structure of π-conjugated block on the CDSA of BCPs containing a crystalline π-conjugated segment. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application In Synthesis of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amineIn 2018 ,《Affinity Enhancement of Protein Ligands by Reversible Covalent Modification of Neighboring Lysine Residues》 appeared in Angewandte Chemie, International Edition. The author of the article were Dal Corso, Alberto; Catalano, Marco; Schmid, Anja; Scheuermann, Joerg; Neri, Dario. The article conveys some information:

The discovery of protein ligands, capable of forming a reversible covalent bond with amino acid residues on a protein target of interest, may represent a general strategy for the discovery of potent small-mol. inhibitors. The authors analyzed the ability of different aromatic aldehydes to form imines by reaction with lysine using 1H NMR techniques. 2-Hydroxybenzaldehyde derivatives were found to efficiently form imines in the millimolar concentration range. These benzaldehyde derivatives could increase the binding affinity of protein ligands towards the cognate protein target. Affinity maturation was achieved not only by displaying ligand and aldehyde moieties on two complementary locked nucleic acid strands but also by incorporating the binding fragments in a single small-mol. ligand. The affinity gain was only observed when lysine residues were accessible in the immediate surroundings of the ligand-binding site and could be abrogated by quenching with a molar excess of hydroxylamine. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Recommanded Product: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Seale, James S. W.; Song, Bo; Qiu, Yunyan; Stoddart, J. Fraser published an article in Journal of the American Chemical Society. The title of the article was 《Precise Non-Equilibrium Polypropylene Glycol Polyrotaxanes》.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The author mentioned the following in the article:

Traditionally, the synthesis of polyrotaxanes has been limited by synthetic methods that rely on an innate affinity between the rings and the polymer chains. The use of rotaxane-forming mol. pumps allows this limitation to be circumvented in the production of non-equilibrium polyrotaxanes in which rings are trapped on polymer chains for which they have little or no affinity. Pumping cassettes, each composed of a bipyridinium unit linked (i) by a bismethylene bridge to a terminal 2,6-dimethylpyridinium cationic unit and (ii) by a methylene group to an isopropylphenylene steric barrier, were attached using copper-catalyzed azide-alkyne cycloadditions to the ends of a polypropylene glycol (PPG) chain of number-average mol. weight Mn ≈ 2200. Using a one-pot electrosynthetic protocol, a series of PPG-based polyrotaxanes with cyclobis(paraquat-p-phenylene) as the rings were synthesized. Despite the steric bulk of the PPG backbone, it was found to be a suitable collecting chain for threading up to 10 rings. The pumping of two rings is sufficient to render these hydrophobic polymers soluble in aqueous solution Their hydrodynamic diameters and diffusion constants vary according to the number of pumped rings. The non-equilibrium nature of these polyrotaxanes is manifested in their gradual degradation and dethreading at elevated temperatures The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Bateman, Leslie A.; Zaro, Balyn W.; Miller, Stephanie M.; Pratt, Matthew R. published 《Correction to “”An Alkyne-Aspirin Chemical Reporter for the Detection of Aspirin-Dependent Protein Modification in Living Cells”” [Erratum to document cited in CA159:508597]》.Journal of the American Chemical Society published the findings.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

In the original publication, The incorrect IUPAC name for AspAlk was given; the correction is provided here. In the original publication, The deuterated solvent used to collect the 1H NMR was incorrect; the correction is provided here. In the original publication, The deuterated solvent used to collect the 13C NMR was incorrect; the correction is provided here. In the original publication, The peak list for the 13C NMR was incorrect; the correction is provided here. The experimental process involved the reaction of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Pezzato, Cristian; Nguyen, Minh T.; Kim, Dong Jun; Anamimoghadam, Ommid; Mosca, Lorenzo; Stoddart, J. Fraser published 《Controlling Dual Molecular Pumps Electrochemically》.Angewandte Chemie, International Edition published the findings.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Artificial mol. machines can be operated using either phys. or chem. inputs. Light-powered motors display clean and autonomous operations, whereas chem. driven machines generate waste products and are intermittent in their motions. Herein, we show that controlled changes in applied electrochem. potentials can drive the operation of artificial mol. pumps in a semi-autonomous manner-i.e., without the need for consecutive additions of chem. fuel(s). The electroanal. approach described in this Communication promotes the assembly of cyclobis(paraquat-p-phenylene) rings along a pos. charged oligomeric chain, providing easy access to the formation of multiple mech. bonds by means of a controlled supply of electricity. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Name: Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics