Tag: 500-600

Cramer, Jonathan; Lakkaichi, Adem; Aliu, Butrint; Jakob, Roman P.; Klein, Sebastian; Cattaneo, Ivan; Jiang, Xiaohua; Rabbani, Said; Schwardt, Oliver; Zimmer, Gert; Ciancaglini, Matias; Abreu Mota, Tiago; Maier, Timm; Ernst, Beat published an article in 2021. The article was titled 《Sweet drugs for bad bugs: A glycomimetic strategy against the DC-SIGN-mediated dissemination of SARS-CoV-2》, and you may find the article in Journal of the American Chemical Society.Application of 510758-28-8 The information in the text is summarized as follows:

The C-type lectin receptor DC-SIGN is a pattern recognition receptor expressed on macrophages and dendritic cells. It has been identified as a promiscuous entry receptor for many pathogens, including epidemic and pandemic viruses such as SARS-CoV-2, Ebola virus, and HIV-1. In the context of the recent SARS-CoV-2 pandemic, DC-SIGN-mediated virus dissemination and stimulation of innate immune responses has been implicated as a potential factor in the development of severe COVID-19. In this study, we report on the discovery of a new class of potent glycomimetic DC-SIGN antagonists from a focused library of triazole-based mannose analogs, e.g. I. Structure-based optimization of an initial screening hit yielded a glycomimetic ligand with a more than 100-fold improved binding affinity compared to Me α-D-mannopyranoside. The identified ligand was employed for the synthesis of multivalent glycopolymers that were able to inhibit SARS-CoV-2 spike glycoprotein binding to DC-SIGN-expressing cells, as well as DC-SIGN-mediated trans-infection of ACE2+ cells by SARS-CoV-2 spike protein-expressing viruses, in nanomolar concentrations In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Application of 510758-28-8)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Application of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2019,Applied Organometallic Chemistry included an article by Fischer-Durand, Nathalie; Lizinska, Daria; Guerineau, Vincent; Rudolf, Bogna; Salmain, Michele. Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine. The article was titled 《’Clickable’ cyclopentadienyl iron carbonyl complexes for bioorthogonal conjugation of mid-infrared labels to a model protein and PAMAM dendrimer》. The information in the text is summarized as follows:

Owing to the intrinsic limitations of the conventional bioconjugation methods involving native nucleophilic functions of proteins, authors sought to develop alternative approaches to introduce metallocarbonyl IR labels onto proteins on the basis of the [3 + 2] dipolar azide-alkyne cycloaddition (AAC). To this end, two cyclopentadienyl iron dicarbonyl (Fp) complexes carrying a terminal or a strained alkyne handle were synthesized. Their reactivity was examined towards a model protein and poly (amidoamine) (PAMAM) dendrimer, both carrying azido groups. While the copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) proceeded smoothly with the terminal alkyne metallocarbonyl derivative, labeling by strain-promoted azide-alkyne cycloaddition (SPAAC) was less successful in terms of final coupling ratios. IR spectral characterization of the bioconjugates showed the presence of two bands in the 2000 cm-1 region, owing to the stretching vibration modes of the carbonyl ligands of the Fp entities. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Reference of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)aminePolytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Related Products of 510758-28-8In 2018 ,《Supercritical Angle Fluorescence Characterization Using Spatially Resolved Fourier Plane Spectroscopy》 was published in Analytical Chemistry (Washington, DC, United States). The article was written by Shirley, Finub James; Neutens, Pieter; Vos, Rita; Mahmud-Ul-Hasan, Md.; Lagae, Liesbet; Verellen, Niels; Van Dorpe, Pol. The article contains the following contents:

Most fluorescent immunoassays require a wash step prior to read-out due to the otherwise overwhelming signal of the large number of unbound (bulk) fluorescent mols. that dominate over the signal from the mols. of interest, usually bound to a substrate. Supercritical angle fluorescence (SAF) sensing is one of the most promising alternatives to total internal reflection fluorescence for fluorescence imaging and sensing. However, detailed exptl. investigation of the influence of collection angle on the SAF surface sensitivity, i.e., signal to background ratio (SBR), is still lacking. In this Letter, we present a novel technique that allows to discriminate the emission patterns of free and bound fluorophores simultaneously by collecting both angular and spectral information. The spectrum was probed at multiple positions in the back focal plane using a multimode fiber connected to a spectrometer and the difference in intensity between two fluorophores was used to calculate the SBR. Our study clearly reveals that increasing the angle of SAF collection enhances the surface sensitivity, albeit at the cost of decreased signal intensity. Furthermore, our findings are fully supported by full-field 3D simulations. In addition to this study using Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine, there are many other studies that have used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Related Products of 510758-28-8) was used in this study.

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) is a polytriazolylamine ligand which stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Related Products of 510758-28-8

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2022,Pollastri, Sara; Delaunay, Clara; Thepaut, Michel; Fieschi, Franck; Bernardi, Anna published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Glycomimetic ligands block the interaction of SARS-CoV-2 spike protein with C-type lectin co-receptors》.Synthetic Route of C30H30N10 The author mentioned the following in the article:

The C-type lectin receptors DC-SIGN and L-SIGN bind to glycans on the SARS-CoV-2 spike glycoprotein and promote trans-infection of ACE2-expressing cells. We tested C2 triazole-modified mono- and pseudo-di-mannosides as inhibitors of DC/L-SIGN binding to a model mannosylated protein (Man-BSA) and to SARS-CoV2 spike, finding that they inhibit the interaction of both lectins with the spike glycoprotein in a Surface Plasmon Resonance (SPR) assay and are more potent than mannose by up to 36-fold (DC-SIGN) and 10-fold (L-SIGN). The mols. described here are the first known glycomimetic ligands of L-SIGN. In the experiment, the researchers used many compounds, for example, Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Synthetic Route of C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Synthetic Route of C30H30N10

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Gan, Weiping; Cao, Xiaosong; Shi, Yi; Zou, Lei; Gao, Haifeng published 《Ligand effect in the synthesis of hyperbranched polymers via copper-catalyzed azide-alkyne cycloaddition polymerization (CuAACP)》.Journal of Polymer Science, Part A: Polymer Chemistry published the findings.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

Copper-catalyzed azide-alkyne cycloaddition polymerization (CuAACP) of AB2 monomers demonstrated a chain-growth mechanism without any external ligand because of the complexation of in situ formed triazole groups with Cu catalysts. In this study, we explored the use of various ligands that affected the polymerization kinetics to tune the polymers’ mol. weights and the degree of branching (DB). Eight ligands were studied, including polyethylene glycol monomethyl ether (PEG350, Mn = 350), tris(benzyltriazolylmethyl)amine (TBTA), 2,6-bis(1-undecyl-1H-benzo[d]imidazol-2-yl)pyridine (Py(DBim)2), 2,2′-bipyridyl (bpy), 4,4′-di-n-nonyl-2,2′-bipyridine (dNbpy), N,N,N’,N”,N”-pentamethyldiethylenetriamine (PMDETA), N,N,N’,N”,N”-penta(n-butyl)diethylenetriamine (PBuDETA), and N,N,N’,N”,N”-pentabenzyldiethylenetriamine (PBnDETA). All ligands except PEG350 exhibited stronger coordination with Cu(I) than the polytriazole polymer, which freed the Cu catalyst from polymers and resulted in dominant step-growth polymerization with simultaneous chain-growth feature. Meanwhile, the use of PEG350 ligand retained the confined Cu in the polymer, demonstrating a chain-growth mechanism, but lower polymer mol. weights as compared with the no-external-ligand polymerization Results indicated that aliphatic substituent groups on ligands had little effect on the mol. weights and DB of the polymers, but rigid aromatic substituent groups decreased both values. By varying the ligand species and amounts, hyperbranched polymers with DB value ranging from 0.53 ([TBTA]0/[Cu]0 = 5) to 0.98 ([PMDETA]0/[Cu]0 = 2) have been achieved. © 2018 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2018. The experimental part of the paper was very detailed, including the reaction process of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Androvic, Ladislav; Woldrichova, Lucie; Jozefjakova, Klaudia; Pechar, Michal; Lynn, Geoffrey M.; Kankova, Dana; Malinova, Lenka; Laga, Richard published their research in Macromolecules (Washington, DC, United States) in 2021. The article was titled 《Cyclotriphosphazene-Based Star Copolymers as Structurally Tunable Nanocarriers with Programmable Biodegradability》.COA of Formula: C30H30N10 The article contains the following contents:

Myriad nanocarriers have been developed to improve the therapeutic index of low-mol.-weight drugs for cancer treatment, but many have suboptimal size and/or are too stable for optimal penetration into tumors and their subsequent excretion from the body. To address this challenge, we developed a series of novel nanocarriers based on star polymers consisting of hydrophilic poly[N-(2-hydroxypropyl)methacrylamide] (PHPMA) or poly(ethylene glycol) (PEG) polymer arms attached to hexavalent cyclotriphosphazene (CTP)-derived cores through either stable or stimuli-responsive linkers. The star polymers were assembled using either “”grafting from”” or “”grafting onto”” approaches and characterized by quant. arm substitution at the core. The resulting star polymers were precisely defined water-soluble nanomaterials with a suitable hydrodynamic size (~10-25 nm) for tumor uptake; those with stimuli-responsive linkers exhibited programmable pH- or cathepsin-mediated degradability. Finally, low-mol.-weight drugs-an anthracycline-based cancerostatic and an imidazoquinoline-based immunostimulant-were linked to exemplary CTP-based star polymers to demonstrate their suitability for drug delivery. In the experiment, the researchers used Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8COA of Formula: C30H30N10)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.COA of Formula: C30H30N10Polytriazolylamines were synthesized by the copper(I)-catalyzed ligation of azides and alkynes.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

In 2018,Wi, Youngjin; Le, Hoa Thi; Verwilst, Peter; Sunwoo, Kyoung; Kim, Seo Jin; Song, Jung Eun; Yoon, Hey Young; Han, Geon; Kim, Jong Seung; Kang, Chulhun; Kim, Tae Woo published 《Modulating the GSH/Trx selectivity of a fluorogenic disulfide-based thiol sensor to reveal diminished GSH levels under ER stress》.Chemical Communications (Cambridge, United Kingdom) published the findings.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine The information in the text is summarized as follows:

We synthesized a fluorogenic disulfide-based naphthalimide thiol probe (ER-Naph) with a hydrophilic endoplasmic reticulum (ER)-guiding glibenclamide unit. Its ER targeting ability and high selectivity to glutathione (GSH) over thioredoxin (Trx), a potent competitor, were clearly demonstrated, both in solution and in vitro. Finally, a confocal microscopic investigation revealed that GSH levels in the ER were dramatically decreased under thapsigargin, brefeldin A, and tunicamycin-induced ER stress models. In the part of experimental materials, we found many familiar compounds, such as Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine)

Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine(cas: 510758-28-8) can stabilizes Cu(I) towards disproportionation and oxidation thus enhancing its catalytic effect in the azide-acetylene cycloaddition.Quality Control of Tris((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amine

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics