Tag: M.W=150-200

Nugent, Jeremy published the artcileA General Route to Bicyclo[1.1.1]pentanes through Photoredox Catalysis, Application In Synthesis of 143426-50-0, the main research area is bicyclopentane preparation photoredox catalyst halide carbocyclepropellane addition.

Photoredox catalysis has transformed the landscape of radical-based synthetic chem. Additions of radicals generated through photoredox catalysis to carbon-carbon π-bonds are well-established; however, this approach has yet to be applied to the functionalization of carbon-carbon σ-bonds. Here, the authors report the first such use of photoredox catalysis to promote the addition of organic halides to the carbocycle [1.1.1]propellane; the product bicyclo[1.1.1]pentanes (BCPs) are motifs of high importance in the pharmaceutical industry and in materials chem. Showing broad substrate scope and functional group tolerance, this methodol. results in the first examples of bicyclopentylation of sp2 carbon-halogen bonds to access (hetero)arylated BCPs, as well as the functionalization of nonstabilized sp3 radicals. Substrates containing alkene acceptors allow the single-step construction of polycyclic bicyclopentane products through unprecedented atom transfer radical cyclization cascades, while the potential to accelerate drug discovery is demonstrated through late-stage bicyclopentylations of natural product-like and drug-like mols. Mechanistic studies demonstrate the importance of the photocatalyst in this chem. and provide insight into the balance of radical stability and strain relief in the reaction cycle.

ACS Catalysis published new progress about Photocatalysts. 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, Application In Synthesis of 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Loubidi, Mohammed published the artcilePd-catalyzed Suzuki/Sonogashira cross-coupling reaction and the direct sp3 arylation of 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, Application of 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is methyltriazolopyrimidine chloro preparation aryl alkyne palladium catalyst Sonogashira coupling; arylalkynyl methyltriazolopyrimidine preparation; chloro methyltriazolopyrimidine preparation arylboronic acid palladium catalyst Suzuki coupling; aryl methyltriazolopyrimidine preparation bromobenzene palladium catalyst arylation; benzyl aryl methyltriazolopyrimidine preparation.

A rapid and efficient method was reported for the synthesis of the [1,2,4]triazolo[1,5-a]pyrimidine motif. Palladium catalyzed Suzuki and Sonogashira cross coupling reactions on 7-chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine were performed. The direct sp3 arylation of compounds resulting from the Suzuki reaction was then carried out.

Tetrahedron Letters published new progress about Arylation. 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Application of 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Campos, Joana F. published the artcileA greener and efficient method for nucleophilic aromatic substitution of nitrogen-containing fused heterocycles, Quality Control of 24415-66-5, the main research area is chloro heteroarenopyrimidine amine nucleophilic aromatic substitution green chem; amino heteroarenopyrimidine preparation; PEG-400; nitrogen fused heterocycles; nucleophilic aromatic substitution.

A simple and efficient methodol. for the nucleophilic aromatic substitution of nitrogen-containing fused heterocycles with interesting biol. activities was developed in an environmentally sound manner using polyethylene glycol (PEG-400) as the solvent, lead to the expected compounds in excellent yields only in five minutes.

Molecules published new progress about Aromatic nitrogen heterocycles Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Quality Control of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hu, Yongke published the artcileEfficient and selective palladium-catalyzed direct oxidative esterification of benzylic alcohols under aerobic conditions, COA of Formula: C9H9N3O, the main research area is aliphatic benzylic alc oxidative esterification palladium; alkyl benzoate preparation; palladium oxidative esterification catalyst.

A highly efficient palladium-catalyzed approach for the direct oxidative esterification of benzylic alcs. with methanol and long-chain aliphatic alcs. under mild conditions has been achieved. This practical catalyst system exhibits a broad substrate scope and good functional group tolerance. Catalytic amount of Bi(OTf)3 is used as co-catalyst to improve the activity and selectivity of the reactions. A variety of esters are obtained in yields of 43-96%.

Tetrahedron published new progress about Aliphatic alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, COA of Formula: C9H9N3O.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hu, Yongke published the artcilePractical CuCl/DABCO/4-HO-TEMPO-catalyzed oxidative synthesis of nitriles from alcohols with air as oxidant, Application In Synthesis of 143426-50-0, the main research area is copper chloride DABCO TEMPO oxidation alc; nitrile preparation green.

A mild and efficient methodol. for the direct oxidative synthesis of nitriles from easily available alcs. and aqueous ammonia by employing CuCl/DABCO/4-HO-TEMPO as the catalysts is described. This protocol uses the air as a green oxidant and aqueous ammonia as the nitrogen source at room temperature A variety of aryl, heterocyclic and allylic alcs. are smoothly converted into the corresponding nitriles in good to excellent yields.

Chinese Chemical Letters published new progress about Aralkyl alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, Application In Synthesis of 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Fuerstner, Alois published the artcileIron-Catalyzed Cross-Coupling Reactions, Quality Control of 24415-66-5, the main research area is iron complex cross coupling catalyst organometallic compound; aryl chloride triflate tosylate coupling iron catalyst; heteroaryl chloride triflate tosylate coupling iron catalyst; green chem iron complex cross coupling catalyst.

Simple iron salts such as FeCln, Fe(acac)n (n = 2,3) or the salen complex I turned out to be highly efficient, cheap, toxicol. benign, and environmentally friendly precatalysts for a host of cross-coupling reactions of alkyl or aryl Grignard reagents, zincates, or organomanganese species with aryl and heteroaryl chlorides, triflates, and even tosylates. An “”inorganic Grignard reagent”” of the formal composition [Fe(MgX)2], prepared in situ, likely constitutes the propagating species responsible for the catalytic turnover, which occurs in many cases at an unprecedented rate even at or below room temperature Because of the exceptionally mild reaction conditions, a series of functional groups such as esters, ethers, nitriles, sulfonates, sulfonamides, thioethers, acetals, alkynes, and -CF3 groups are compatible. The method also allows for consecutive cross-coupling processes in one pot, as exemplified by the efficient preparation of compound II, and has been applied to the first synthesis of the cytotoxic marine natural product montipyridine (III). In contrast to the clean reaction of (hetero)aryl chlorides, the corresponding bromides and iodides are prone to a reduction of their C-X bonds in the presence of the iron catalyst.

Journal of the American Chemical Society published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Quality Control of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Campos, Joana F. published the artcileEucalyptol as new solvent for the synthesis of heterocycles containing oxygen, sulfur and nitrogen, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, the main research area is fused heterocyclic compound one pot preparation green chem.

The first investigation of the use of eucalyptol as a new solvent for organic transformations was reported. Heterocycles containing oxygen, sulfur and nitrogen were chosen as targets or as starting materials for widely used palladium-catalyzed cross-coupling reactions, i.e. Suzuki-Miyaura and Sonogashira-Hagihara reactions. Eucalyptol turned out to be a viable sustainable alternative to common solvents.

Green Chemistry published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Name: 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Lou, Ji-Cong published the artcileMetal-Free Oxidation of Trichloroacetimidates to Aldehydes, HPLC of Formula: 143426-50-0, the main research area is alc trichloroacetonitrile DBU imidation; trichloroacetimidate preparation dimethylsulfoxide oxidation; carbonyl compound preparation.

A metal-free oxidation reaction of trichloroacetimidates to aldehydes or ketones with DMSO as an oxidant was reported. The reaction exhibited a broad range of functional group tolerance. Detailed mechanistic studies were performed with the aid of NMR, in-situ IR spectroscopy, GC-MS anal. and 18O-labeling experiments

Asian Journal of Organic Chemistry published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, HPLC of Formula: 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Hu, Yongke published the artcileDirect oxidative esterification of alcohols catalyzed by a nitrogen-doped carbon black-supported PdBi bimetallic catalyst under ambient conditions, SDS of cas: 143426-50-0, the main research area is PdBi bimetallic catalyzed oxidative esterification alc; aryl ester preparation PdBi bimetallic catalyzed oxidative esterification.

A highly efficient nitrogen-doped carbon black (NCB)-supported PdBi alloy nanocatalyst has been fabricated via a facile coredn. wet chem. approach. The optimal PdBi/NCB shows outstanding catalytic performance with broad substrate scope, good functional group tolerance towards direct oxidative esterification of alcs. under mild conditions in a heterogeneous catalytic system with air as the sole oxidant. A variety of benzylic and allylic alcs. were smoothly reacted with methanol and even with long-chain aliphatic alcs., providing desired esters in good to excellent yields. Moreover, the as-prepared catalyst is easily recycled and can be reused at least five times without a significant loss of catalytic activity. Superior catalytic activity is mainly attributable to the unique structure of the catalyst, including synergetic electronic effect between Pd and Bi, as well as modulated surface character by acidification and N doping for better active components’ anchoring and dispersion, as well as reactants’ adsorption. This study provides a facial, practical, eco-friendly and efficient catalytic system for oxidative esterification of alcs. and shows promising prospect in industrial production

Journal of Materials Science published new progress about Alcohols Role: RCT (Reactant), RACT (Reactant or Reagent). 143426-50-0 belongs to class triazoles, name is 4-(1,2,4-Triazol-1-yl)benzyl Alcohol, and the molecular formula is C9H9N3O, SDS of cas: 143426-50-0.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Campos, Joana F. published the artcileEucalyptol as bio-based solvent for Migita-Kosugi-Stille coupling reaction on O,S,N-heterocycle, Application In Synthesis of 24415-66-5, the main research area is eucalyptol heterocycle Migita Kosugi Stille coupling solvent green.

We report herein an investigation on the use of eucalyptol as new solvent for organic transformations applied to the Migita-Kosugi-Stille palladium-catalyzed cross-coupling reaction. Heterocycles containing oxygen, sulfur and nitrogen were chosen as starting materials. Eucalyptol turned out to be a viable sustainable alternative to common solvents for this reaction.

Catalysis Today published new progress about Aryl chlorides Role: RCT (Reactant), RACT (Reactant or Reagent) (heteroaryl). 24415-66-5 belongs to class triazoles, name is 7-Chloro-5-methyl-[1,2,4]triazolo[1,5-a]pyrimidine, and the molecular formula is C6H5ClN4, Application In Synthesis of 24415-66-5.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics