Tag: M.W=200-250

Matsuda, Yoshiro published the artcileReaction of 4-amino-1,2,4-triazolium salts with polarized olefins, Name: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, the main research area is aminotriazolium salt cyclization polarized olefin; triazolium salt amino cyclization polarized olefin; betaine mesomeric preparation; triazolopyrazole preparation.

The reaction of 4-amino-1,2,4-triazolium salts I (R = Me, CH2Ph, X = iodo, Br) with polarized olefins EtOCH:CR1CO2Et (R1 = CO2Et, NO2) and (MeS)2C:CXY (X = CO2Me, Y = cyano) in the presence of K2CO3 in EtOH or DMSO directly yielded the back-donated 1,6-cyclization products, mesomeric betaines II (R1 = CO2Et, NO2, R2 = H; R1 = cyano, R2 = SMe) via N-vinylimino ylides, while the reaction of the salts I with polarized olefins (MeS)2C:CXY (X = H, Y = NO2; X = SO2Ph, Y = cyano) gave the 1,5-dipolar cyclization products, pyrazoles III and [1,2,4]-triazolo[4,3-b]pyrazole IV.

Heterocycles published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Name: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Temple, Kayla J. published the artcileDiscovery of a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide M4 positive allosteric modulator (PAM) chemotype, Product Details of C7H6BrN3, the main research area is dimethylimidazopyrazinecarboxamide preparation M4 pos allosteric modulator; M(4); Muscarinic acetylcholine receptor; Positive allosteric modulator (PAM); Structure activity relationship (SAR).

This Letter details the authors’ efforts to discover structurally unique M4 PAMs containing 5,6-heteroaryl ring systems. In an attempt to improve the DMPK profiles of the 2,3-dimethyl-2H-indazole-5-carboxamide and 1-methyl-1H-benzo[d][1,2,3]triazole-6-carboxamide cores, the authors studied a plethora of core replacements. This exercise identified a novel 2,3-dimethylimidazo[1,2-a]pyrazine-6-carboxamide core that provided improved M4 PAM activity and CNS penetration.

Bioorganic & Medicinal Chemistry Letters published new progress about Molecular structure-property relationship. 108281-78-3 belongs to class triazoles, name is 6-Bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine, and the molecular formula is C7H6BrN3, Product Details of C7H6BrN3.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Jishkariani, Davit published the artcileCu(I)-Catalyzed Regioselective Synthesis of Pyrazolo[5,1-c]-1,2,4-triazoles, SDS of cas: 39602-93-2, the main research area is terminal alkyne triazolium imide regioselective cycloaddition copper; regioselective preparation; copper regioselective cycloaddition catalyst.

Cycloadditions of terminal alkynes to 1,2,4-triazolium N-imides in the presence of base and Cu(I) afford pyrazolo[5,1-c]-1,2,4-triazoles, e.g., I, regioselectively. The scope of alkynes, the influence of the electronic nature of the leaving group, and variations in the 1-alkyl substituent were examined Quantum chem. calculations were employed to explain the distinct reactivity of the propiolates.

Journal of Organic Chemistry published new progress about Alkynes, α- Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, SDS of cas: 39602-93-2.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Larson, Helen published the artcileNi-Catalyzed C-H Arylation of Oxazoles and Benzoxazoles Using Pharmaceutically Relevant Aryl Chlorides and Bromides, Synthetic Route of 108281-78-3, the main research area is nickel catalyst arylation oxazole benzoxazole pharmaceutically relevant aryl halide.

This manuscript details the development of the nickel-catalyzed arylation of oxazoles and benzoxazoles with aryl halides. A series of aryl, heteroaryl, and druglike electrophiles relevant to pharmaceutical applications were surveyed. The desired arylated products were obtained in synthetically useful yields using electronically and structurally varied aryl halides. The use of microscale high-throughput experimentation was essential for both the rapid identification of optimal reaction parameters and the investigation of the aryl halide scope.

Journal of Organic Chemistry published new progress about Aryl bromides Role: RCT (Reactant), RACT (Reactant or Reagent). 108281-78-3 belongs to class triazoles, name is 6-Bromo-3-methyl-[1,2,4]triazolo[4,3-a]pyridine, and the molecular formula is C7H6BrN3, Synthetic Route of 108281-78-3.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Panmand, Deepak S. published the artcileSynthesis and Direct C2 Functionalization of Imidazolium and 1,2,4-Triazolium N-Imides, Recommanded Product: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, the main research area is aryl imidazolpyrazolole pyrazolotriazole imidazoliumylamide triazoliumylamide preparation fluorescence emission spectra; azoliumimide acetylene aryl iodide arylation alkynylation cyclization.

Pd-catalyzed direct C2 arylation and Cu-catalyzed direct one-pot alkynylation/intramol. cyclization of azolium N-imides are reported. Various acetylenes, aryl iodides, and 1-alkyl substituents were examined The mild protocol allows direct C2 arylation of azolium N-imides without the use of specialized reagents together with novel one-pot regioselective preparations of imidazole-pyrazolo e. g., I, and pyrazolo-1,2,4-triazole e. g., II ring systems. The electronic properties of selected examples were examined by fluorescence spectroscopy.

Journal of Organic Chemistry published new progress about Alkynes, aryl Role: RCT (Reactant), RACT (Reactant or Reagent). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Recommanded Product: 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Schneider, Stefan published the artcileLiquid Azide Salts, Category: triazoles, the main research area is triazole amino azide crystal structure thermal stability ionic liquid.

Ionic liquid azides from azidoethyl, alkyl, and alkenyl substituted derivatives of amino-1,2,4- and -1,2,3-triazoles were prepared and examined for the first time to investigate their structural and phys. properties. All reported salts possess m.ps. below 100 °C. The unique character of these newly discovered ionic liquid azides is based upon the fact that these mols. are not simple protonated salts like previously reported substituted hydrazinium azides. The presence of quaternary nitrogen confers both thermal stability and negligible volatility.

Inorganic Chemistry published new progress about Azides Role: PRP (Properties), SPN (Synthetic Preparation), PREP (Preparation). 39602-93-2 belongs to class triazoles, name is 4-Amino-1-methyl-4H-1,2,4-triazol-1-ium iodide, and the molecular formula is C3H7IN4, Category: triazoles.

Referemce:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics