Tag: M.W=200-250

Sun, Jing published the artcileSynthesis, structure, photophysical and electroluminescent properties of a blue-green self-host phosphorescent iridium(III) complex, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Materials Chemistry and Physics (2015), 392-399, database is CAplus.

A kind of blue-green self-host phosphorescent Ir(III) complex, (CzPhBI)₂Ir(tfmptz) [CzPhBI = 9-(6-(2-phenyl-1-benzimidazolyl)hexyl)-9-carbazole; tfmptz = 2-(5-trifluoromethyl-1,2,4-triazolyl)pyridine], was designed and synthesized. The synthesized Ir(III) complex was characterized by ¹H NMR, ¹⁹F NMR, FTIR, elemental anal. and x-ray single-crystal diffraction, resp. Its thermal properties, optical properties and electrochem. properties were also studied. The host-free organic electroluminescent devices with the configuration of ITO/MoO₃ (3 nm)/NPB (30 nm)/TAPC (15 nm)/(CzPhBI)₂Ir(tfmptz) (30 nm)/TBPI (30 nm)/LiF (1 nm)/Al (100 nm) had been fabricated. The devices exhibited excellent performance indicating that (CzPhBI)₂Ir(tfmptz) was a promising phosphorescent material.

Materials Chemistry and Physics published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C6H5F4NO3S, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Cheng, Wei published the artcileBlue iridium(III) complexes with high internal quantum efficiency based on 4-(pyridin-3-yl)pyrimidine derivative and their electroluminescent properties, Name: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Dyes and Pigments (2020), 108257, database is CAplus.

Three novel highly efficient blue bicyclometalated Ir(III) complexes (Ir1-Ir3) were designed and synthesized with 4-(2,6-difluoropyridin-3-yl)-6-mesitylpyrimidine as primary ligands. The alternation of ancillary ligands had precisely regulated their emitting peaks from sky-blue to deep-blue. These complexes exhibit unimodal emission with PLQYs >90% and lifetimes shorter than 1.1μs. These complexes also show good thermal stability with T_d > 320°. The OLED using complex Ir3 as emitter in 13% exhibited a maximum luminous efficiency of 16.9 cd A^-1 with a high EQE of 13.0%. The CIE coordinates of this device are (0.15, 0.16), which are close to the standard blue color region.

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Name: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Hu, Fa-Chun published the artcileDesign of Os^II-based Sensitizers for Dye-Sensitized Solar Cells: Influence of Heterocyclic Ancillaries, COA of Formula: C8H5F3N4, the publication is ChemSusChem (2013), 6(8), 1366-1375, database is CAplus and MEDLINE.

A series of Os^II sensitizers (TFOS-x, in which x = 1, 2, or 3) with a single 4,4′-dicarboxy-2,2′-dipyridine (H₂dcbpy) anchor and two chelating 2-pyridyl (or 2-pyrimidyl) triazolate ancillaries was successfully prepared Single-crystal X-ray structural anal. showed that the core geometry of the Os^II-based sensitizers consisted of one H₂dcbpy unit and two eclipsed cis-triazolate fragments; this was notably different from the Ru^II-based counterparts, in which the azolate (both pyrazolate and triazolate) fragments are located at the mutual trans-positions. The basic properties were extensively probed by using spectroscopic and electrochem. methods as well as time-dependent d. functional theory (TD-DFT) calculations Fabrication of dye-sensitized solar cells (DSCs) was then attempted by using the I^–/I₃^–-based electrolyte solution One such DSC device, which utilized TFOS-2 as the sensitizer, showed promising performance characteristics with a short-circuit c.d. (J_SC) of 15.7 mA cm^-2, an open-circuit voltage of 610 mV, a fill factor of 0.63, and a power conversion efficiency of 6.08 % under AM 1.5G simulated one-sun irradiation Importantly, adequate incident photon-to-current conversion efficiency performances were observed for all TFOS derivatives over the wide spectral region of 450-950 nm, showing a panchromatic light harvesting capability that extended into the near-IR regime. The results underlined a feasible strategy for maximizing J_SC and increasing the efficiency of DSCs.

ChemSusChem published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, COA of Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Sun, Peng published the artcileBlue-emitting Ir(III) complexes using fluorinated bipyridyl as main ligand and 1,2,4-triazol as ancillary ligand: syntheses, photophysical properties and performances in devices, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Tetrahedron (2016), 72(50), 8335-8341, database is CAplus.

The blue-light-emitting Ir(III) complexes using 2-(3-(trifluoromethyl) -1H-1,2,4-triazol-5-yl)pyridine and fluorinated 2-phenylpyridine as ligands were synthesized and characterized in details. Their mol. structures were confirmed by ¹H NMR, FT-IR and elemental analyzer. The emission peaks of complex (F_2,4ppy)₂Ir(tfmptz) using 2-(2,4-difluorophenyl)pyridine as main ligand are located at 457 and 481 nm. Increasing the number of F atoms leads to a lower the LUMO energy level. Phosphorescent organic light-emitting devices doped the synthesized Ir(III) complexes into 4,4′-N,N’-dicarbazolebiphenyl as emitting layers were fabricated. The based-(F_3,4,5ppy)₂Ir(tfmptz) device shows the maximum current efficiency of 9.9 cd/A with the electroluminescent peaks at 471 and 502 nm.

Tetrahedron published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C4H5F3O, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Xu, Huixia published the artcileSynthesis and photoelectric performances of blue-green emitting iridium phenylpyridine complexes using N,N’-heteroaromatic ancillary ligands, Computed Properties of 219508-27-7, the publication is New Journal of Chemistry (2015), 39(7), 5293-5299, database is CAplus.

Four iridium complexes [(ppy)₂IrL] containing different ancillary ligands [HL = 2-(5-R-2H-1,2,4-triazol-3-yl)pyridine, where R = 4-CF₃C₆H₄ (Htfmpptz), 4-FC₆H₄ (Hfpptz), CF₃ (Htfmptz); Hppy = 2-phenylpyridine] were synthesized and characterized. Their mol. structures were identified by x-ray single crystal diffraction. The effects of ancillary ligands on the photophys. and luminescence behaviors were investigated. The emission maximum peaks of (ppy)₂Ir(tfmpptz), (ppy)₂Ir(fpptz) and (ppy)₂Ir(tfmptz) in CH₂Cl₂ solution appear at 485, 487 and 483 nm, resp. Phosphorescent organic light-emitting devices (PhOLEDs) were fabricated using these complexes doped in CBP as an emitting layer.

New Journal of Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C7H8O3, Computed Properties of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Tran, Kim T. published the artcileA Comparative Assessment Study of Known Small-Molecule Keap1-Nrf2 Protein-Protein Interaction Inhibitors: Chemical Synthesis, Binding Properties, and Cellular Activity, HPLC of Formula: 1799973-82-2, the publication is Journal of Medicinal Chemistry (2019), 62(17), 8028-8052, database is CAplus and MEDLINE.

Inhibiting the protein-protein interaction (PPI) between the transcription factor Nrf2 and its repressor protein Keap1 has emerged as a promising strategy to target oxidative stress in diseases, including central nervous system (CNS) disorders. Numerous non-covalent small-mol. Keap1-Nrf2 PPI inhibitors have been reported to date, but many feature suboptimal physicochem. properties for permeating the blood-brain barrier, while others contain problematic structural moieties. Here, we present the first side-by-side assessment of all reported Keap1-Nrf2 PPI inhibitor classes using fluorescence polarization, thermal shift assay, and surface plasmon resonance-and further evaluate the compounds in an NQO1 induction cell assay and in counter tests for nonspecific activities. Surprisingly, half of the compounds were inactive or deviated substantially from reported activities, while we confirm the cross-assay activities for others. Through this study, we have identified the most promising Keap1-Nrf2 inhibitors that can serve as pharmacol. probes or starting points for developing CNS-active Keap1 inhibitors.

Journal of Medicinal Chemistry published new progress about 1799973-82-2. 1799973-82-2 belongs to triazoles, auxiliary class Other Aromatic Heterocyclic,Bromide,Ether, name is 5-Bromo-7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazole, and the molecular formula is C4H3Cl2N3, HPLC of Formula: 1799973-82-2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Takizawa, Shin-Ya published the artcilePhosphorescent iridium complexes based on 2-phenylimidazo[1,2-a]pyridine ligands: tuning of emission color toward the blue region and application to polymer light-emitting devices, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Inorganic Chemistry (2007), 46(10), 4308-4319, database is CAplus and MEDLINE.

New blue-phosphorescent Ir(III) complexes 1-14 with ligands of 2-phenylimidazo[1,2-a]pyridine (pip) derivatives were successfully prepared, and their electrochem., photophys. and electroluminescent (EL) properties were systematically studied. The emission maxima are significantly dependent on the substituents on the Ph ring at 489-550 nm. For instance, electron-withdrawing groups such as F and CF₃ shift the emission maxima to shorter wavelengths by lowering the HOMO levels (complexes 4-8), whereas the extended π-conjugation leads to bathochromic shifts (2-3). To obtain further information about the frontier orbital, substitution effects on the imidazole part were also studied here, and electron-withdrawing or -donating substituents on the imidazole ring affected the emission maxima (9, 557 nm; 10, 525 nm). These results including their oxidation potentials suggest that the HOMO of the pip-based complex is a mixture of Ir-d, phenyl-π, and imidazole-π orbitals. From this viewpoint, combination of electron-withdrawing substituents on the Ph ring using another ancillary ligand enabled further blue shifts (13, 468, 499 nm; 14, 464, 494 nm). This new system based on pip is one of the rare examples of Ir complexes whose emissions can be tuned to the blue region. Preliminary polymer light-emitting devices employing the Ir complexes were fabricated, and the devices showed moderate EL efficiencies.

Inorganic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C10H14N2O, Application of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Pallesen, Jakob S. published the artcileDeconstructing Noncovalent Kelch-like ECH-Associated Protein 1 (Keap1) Inhibitors into Fragments to Reconstruct New Potent Compounds, SDS of cas: 1799973-82-2, the publication is Journal of Medicinal Chemistry (2021), 64(8), 4623-4661, database is CAplus and MEDLINE.

Targeting the protein-protein interaction (PPI) between nuclear factor erythroid 2-related factor 2 (Nrf2) and Kelch-like ECH-associated protein 1 (Keap1) is a potential therapeutic strategy to control diseases involving oxidative stress. Here, six classes of known small-mol. Keap1-Nrf2 PPI inhibitors were dissected into 77 fragments in a fragment-based deconstruction reconstruction (FBDR) study and tested in four orthogonal assays. This gave 17 fragment hits of which six were shown by X-ray crystallog. to bind in the Keap1 Kelch binding pocket. Two hits were merged into pyrazole I with a 220-380-fold stronger affinity (K_i = 16μM) relative to the parent fragments. Systematic optimization resulted in several novel analogs with K_i values of 0.04-0.5μM, binding modes determined by X-ray crystallog., and enhanced microsomal stability. This demonstrates how FBDR can be used to find new fragment hits, elucidate important ligand-protein interactions, and identify new potent inhibitors of the Keap1-Nrf2 PPI.

Journal of Medicinal Chemistry published new progress about 1799973-82-2. 1799973-82-2 belongs to triazoles, auxiliary class Other Aromatic Heterocyclic,Bromide,Ether, name is 5-Bromo-7-methoxy-1-methyl-1H-benzo[d][1,2,3]triazole, and the molecular formula is C8H8BrN3O, SDS of cas: 1799973-82-2.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Tao, Peng published the artcileHighly efficient thienylquinoline-based phosphorescent iridium(III) complexes for red and white organic light-emitting diodes, Formula: C8H5F3N4, the publication is Organic Electronics (2017), 293-301, database is CAplus.

Highly efficient 2-(thiophen-2-yl)quinoline-based phosphorescent iridium(III) complexes bearing 2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine or picolinic acid as ancillary ligands are designed and synthetised. The variation of ancillary ligands is attempted to finely tune the photophys. properties of these complexes, especially the solution phosphorescent quantum yields (Φ_PL), full width at half maximum (FWHM), etc. The picolinic acid-based complex displays the slightly red-shifted dual-peak emission compared to triazolpyridine-based one. The complexes show bright emission with broad FWHM up to 83 nm, and the emissions are in red region with the very high absolute Φ_PL up to 0.76 in solution Moreover, high-performance red and three-color-based white organic light-emitting diodes (OLEDs) with excellent color stability have been fabricated. The maximum external quantum efficiencies of red and white OLEDs can reach 16.2% and 15.1%, resp. The maximum current efficiency and power efficiency of white OLED are as high as 35.5 cd A^-1 and 34.0 lm W^-1, resp. Especially, the designed white OLED exhibits excellent spectral stability under wide operating voltage range, and the 1931 Commission Internationale de L’Eclairage of white OLED only changes from (0.43, 0.42) to (0.44, 0.44), the color rendering index is in a narrow range of 75-77.

Organic Electronics published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C15H21BO3, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Tong, Bi-hai published the artcileHigh-brightness solution-processed phosphorescent OLEDs with pyrimidine-based iridium(III) complexes, Category: triazoles, the publication is RSC Advances (2016), 6(41), 34970-34976, database is CAplus.

Two heteroleptic cyclometalated iridium(III) complexes, Ir(ppm)₂(pic) and Ir(ppm)₂(taz), using 4,6-di-Ph pyrimidine (Hppm) as a cyclometalating ligand, were successfully synthesized and characterized. Strong emission at 555 and 532 nm with high photoluminescence quantum yields of 83% and 86% in PMMA at 298 k were obtained for Ir(ppm)₂(pic) and Ir(ppm)₂(taz), resp. Solution-processed organic light-emitting diodes (OLEDs) based on Ir(ppm)₂(pic) and Ir(ppm)₂(taz) showed high-brightness of 112 233 and 125 072 cd m^-2, peak current efficiencies of 30.6 and 40.4 cd A^-1 and maximum external quantum efficiencies of 10.4 and 17.3%, resp., accompanied by very low efficiency roll-off values. The ancillary ligand taz tuned the emission to saturated green, and more importantly, it can significantly increase the spectral stability and device efficiency.

RSC Advances published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C10H16O2, Category: triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics