Tag: M.W=200-250

Chou, Ho-Hsiu’s team published research in ACS Applied Materials & Interfaces in 5 | CAS: 219508-27-7

ACS Applied Materials & Interfaces published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Quality Control of 219508-27-7.

Chou, Ho-Hsiu published the artcileNew Iridium Dopants for White Phosphorescent Devices: Enhancement of Efficiency and Color Stability by an Energy-Harvesting Layer, Quality Control of 219508-27-7, the publication is ACS Applied Materials & Interfaces (2013), 5(13), 6168-6175, database is CAplus and MEDLINE.

A new light blue complex (fmoppy)2Ir(tfpypz) [bis(4′-fluoro-6′-methoxylphenylpyridinato)[3-(trifluoromethyl)-5-(pyridin-2-yl)-1,2,4-triazolato]iridium] and a new orange complex (dpiq)2Ir(acac) [acetylacetonatobis(3,4-diphenylisoquinoline)iridium] were synthesized. These 2 complexes were used as the dopants for the fabrication of 2-element white phosphorescent devices. Via the introduction of a thin energy-harvesting layer (EHL) to harvest the extra energy and exciton from the emission zone, highly efficient 2-element white devices with excellent color stability were created. One of the best devices shows yellow-white color emission with an extremely high external quantum efficiency (EQE) of 21.5% and a current efficiency of 68.8 cd/A. The other device gave a pure white emission with an external quantum efficiency of 19.2% and a current efficiency of 53.2 cd/A. At a high brightness of 1000 cd/m2, the EQE still remains ≤18.9 and 17.2%. With a brightness of 1000-10000 cd/m2, the CIE coordinates of these 2 devices shift by only (0.02, ≤0.01). The white phosphorescent devices with the EHL showed much higher efficiency and better color stability than the 1 without the EHL. Crystallog. data are given.

ACS Applied Materials & Interfaces published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Quality Control of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Hu, Wei-Kang’s team published research in Dyes and Pigments in 150 | CAS: 219508-27-7

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Formula: C8H5F3N4.

Hu, Wei-Kang published the artcileBlue-to-green electrophosphorescence from iridium(III) complexes with cyclometalated pyrimidine ligands, Formula: C8H5F3N4, the publication is Dyes and Pigments (2018), 284-292, database is CAplus.

A series of 4, 6-disubstituted pyrimidine based iridium(III) complexes (1-5), has been synthesized with a simple method. Single X-ray structural analyses were conducted on 5 to reveal their coordination arrangement. These complexes exhibit almost single peak emission with the peak wavelength located in the range of 468-505 nm and quantum yields of over 75%. The relationship between photophys. properties and the substituent nature of the complexes was discussed by d. functional theory. Organic light-emitting diodes (OLEDs) were also fabricated using these complexes as dopants in 15 wt%. The green device based on 1 shows a maximum external quantum efficiency, current efficiency, and power efficiency of 9.7%, 46.5 cd A-1 and 29.0 lm W-1, resp., while the blue device based on 5 exhibits an external quantum efficiency of up to 14.5%, peak luminance efficiency of 28.0 cd A-1 and power efficiency of 19.5 lm W-1. Moreover, the Commission Internationale de L’Eclairage (CIE) coordinates of 5 are (0.15, 0.30) which is closer to blue emission than that of FIrpic.

Dyes and Pigments published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Formula: C8H5F3N4.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Yang, Cheng-Han’s team published research in Inorganic Chemistry in 44 | CAS: 219508-27-7

Inorganic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H6ClNO, SDS of cas: 219508-27-7.

Yang, Cheng-Han published the artcileHeteroleptic Cyclometalated Iridium(III) Complexes Displaying Blue Phosphorescence in Solution and Solid State at Room Temperature, SDS of cas: 219508-27-7, the publication is Inorganic Chemistry (2005), 44(22), 7770-7780, database is CAplus and MEDLINE.

A series of heteroleptic Ir(III) metal complexes 1–3 bearing two N-phenyl-substituted pyrazoles and one 2-pyridyl pyrazole (or triazole) ligands were synthesized and characterized to attain highly efficient, room-temperature blue phosphorescence. The N-phenylpyrazole ligands, dfpzH = 1-(2,4-difluorophenyl)pyrazole, fpzH = 1-(4-fluorophenyl)pyrazole, dfmpzH = 1-(2,4-difluorophenyl)-3,5-dimethylpyrazole, and fmpzH = 1-(4-fluorophenyl)-3,5-dimethylpyrazole, show a similar reaction pattern with respect to the typical cyclometalated (C-N) chelate, which utilizes its ortho-substituted Ph segment to link with the central Ir(III) atom, while the second 2-pyridylpyrazole (or triazole) ligand, namely, fppzH = 3-(trifluoromethyl)-5-(2-pyridyl)pyrazole, fptzH = 3-(trifluoromethyl)-5-(2-pyridyl)triazole, and hptzH = 3-(heptafluoropropyl)-5-(2-pyridyl)triazole, undergoes typical anionic (N-N) chelation to complete the octahedral framework. X-ray structural analyses on complexes [(dfpz)2Ir(fppz)] (1a) and [(fmpz)2Ir(hptz)] (3d) were established to confirm their mol. structures. Increases of the ππ* energy gaps of the Ir(III) metal complexes were systematically achieved with two tuning strategies. One involves the substitution for one or two fluorine atoms at the N-Ph segment or the introduction of two electron-releasing Me substituents at the pyrazole segment of the H(C-N) ligands. Alternatively, we have applied the more electron-accepting triazolate in place of the pyrazolate segment for the third (N-N)H ligand. Our results, on the basis of steady-state, relaxation dynamics, and theor. approaches, lead to a conclusion that, for complexes 1–3, the weakening of iridium metal-ligand bonding strength in the T1 state plays a crucial role for the fast radiationless deactivation. For the case of [(fmpz)2Ir(hptz)] (3d), a thermal deactivation barrier of 4.8 kcal/mol was further deduced via temperature-dependent studies. The results provide a theor. basis for future design and synthesis of the corresponding analogs suited to blue phosphorescent emitters.

Inorganic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H6ClNO, SDS of cas: 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Tung, Yung-Liang’s team published research in Journal of Materials Chemistry in 15 | CAS: 219508-27-7

Journal of Materials Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C20H21ClN4O4, Category: triazoles.

Tung, Yung-Liang published the artcileOrganic light-emitting diodes based on charge-neutral Os(II) emitters: generation of saturated red emission with very high external quantum efficiency, Category: triazoles, the publication is Journal of Materials Chemistry (2005), 15(4), 460-464, database is CAplus.

The authors report the syntheses of three sublimable charge neutral Os(II) triazolate complexes. Red-emitting organic electroluminescent devices employing one of the materials, either as a dopant in a 4,4′-N,N‘-dicarbazolyl-1,1′-biphenyl or as a neat film, were constructed and evaluated. Changing the hole-transport layer in the devices from 4,4’-bis[N-(1-naphthyl)-N-phenylamino]biphenyl NPB to 9,9-bis(4-di(p-biphenyl)aminophenyl)fluorene (BPAPF) was observed to produce an increase in quantum efficiency, attributed to the higher hole mobility of BPAPF.

Journal of Materials Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C20H21ClN4O4, Category: triazoles.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Cheng, Yi-Ming’s team published research in Advanced Functional Materials in 18 | CAS: 219508-27-7

Advanced Functional Materials published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Application In Synthesis of 219508-27-7.

Cheng, Yi-Ming published the artcileRational design of chelating phosphine functionalized Os(II) emitters and fabrication of orange polymer light-emitting diodes using solution process, Application In Synthesis of 219508-27-7, the publication is Advanced Functional Materials (2008), 18(2), 183-194, database is CAplus.

A new series of charge neutral OsII pyridyl azolate complexes with either bis(diphenylphosphino)methane (dppm) or cis-1,2-bis(diphenylphosphino)ethene (dppee) chelates were synthesized, and their structural, electrochem., photophys. properties and thermodn. relationship were established. For the dppm derivatives , the pyridyl azolate chromophores adopt an eclipse orientation with both azolate segments aligned trans to each other, and with the pyridyl groups resided the sites that are opposite to the phosphorus atoms. In sharp contrast, the reactions with dppee ligand gave rise to the formation of two structural isomers for all three kind of azole chromophores, with both azolate or neutral heterocycles (i.e., pyridyl or isoquinolinyl fragments) located at the mutual trans-disposition around the Os metal (denoted as series of a and b complexes). These chelating phosphines Os(II) complexes show remarkably high thermal stability, among which and several exhibit nearly unitary phosphorescence yield in deaerated solution at RT. A polymer light-emitting device (PLED) prepared using 0.4 mol % of I as dopant in a blend of poly(vinylcarbazole) (PVK) and 30 wt % of 2-tert-butylphenyl-5-biphenyl-1,3,4-oxadiazole (PBD) exhibits yellow emission with brightness of 7208 cd m-2, an external quantum efficiency of 10.4 % and luminous efficiency of 36.1 cd A-1 at c.d. of 20 mA cm-2. Upon changing to 1.6 mol % of II, the result showed even better brightness of 9212 cd m-2, external quantum efficiency of 12.5 % and luminous efficiency of 46.1 cd A-1 at 20 mA cm-2, while the maximum external quantum efficiency of both devices reaches as high as 11.7 % and 13.3 %, resp. The high PL quantum efficiency, non-ionic nature, and short radiative lifetime are believed to be the determining factors for this unprecedented achievement.

Advanced Functional Materials published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Application In Synthesis of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Park, Hea Jung’s team published research in Journal of Organic Chemistry in 78 | CAS: 219508-27-7

Journal of Organic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Application In Synthesis of 219508-27-7.

Park, Hea Jung published the artcileRational Design, Synthesis, and Characterization of Deep Blue Phosphorescent Ir(III) Complexes Containing (4′-Substituted-2′-pyridyl)-1,2,4-triazole Ancillary Ligands, Application In Synthesis of 219508-27-7, the publication is Journal of Organic Chemistry (2013), 78(16), 8054-8064, database is CAplus and MEDLINE.

On the basis of the results of frontier orbital considerations, 4-substituted-2′-pyridyltriazoles were designed to serve as ancillary ligands in 2-phenylpyridine main ligand containing heteroleptic iridium(III) complexes that display deep blue phosphorescence emission. The iridium(III) complexes, Ir1–Ir7, prepared using the new ancillary ligands, were found to display structured, highly quantum efficient (Φp = 0.20-0.42) phosphorescence with emission maxima in the blue to deep blue 448-456 nm at room temperature In accord with predictions based on frontier orbital considerations, the complexes were observed to have emission properties that are dependent on the electronic nature of substituents at the C-4 position of the pyridine moiety of the ancillary ligand. Importantly, placement of an electron-donating Me group at C-4′ of the pyridine ring of the 5-(pyridine-2′-yl)-3-trifluoromethyl-1,2,4-triazole ancillary ligand leads to an iridium(III) complex that displays a deep blue phosphorescence emission maximum at 448 nm in both the liquid and film states at room temperature Finally, an OLED device, constructed using an Ir-complex containing the optimized ancillary ligand as the dopant, was found to emit deep blue color with a CIE of 0.15, 0.18, which is close to the perfect goal of 0.15, 0.15.

Journal of Organic Chemistry published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Application In Synthesis of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Lee, Sunghun’s team published research in Journal of the American Chemical Society in 135 | CAS: 219508-27-7

Journal of the American Chemical Society published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Lee, Sunghun published the artcileDeep-blue phosphorescence from perfluoro carbonyl-substituted iridium complexes, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Journal of the American Chemical Society (2013), 135(38), 14321-14328, database is CAplus and MEDLINE.

The new deep-blue iridium-(III) complexes, (TF)2Ir-(pic), (TF)2Ir-(fptz), (HF)2Ir-(pic), and (HF)2Ir-(fptz), consisting of 2′,4”-difluororphenyl-3-methylpyridine with trifluoromethyl carbonyl or heptafluoropropyl carbonyl at the 3′ position as the main ligand and a picolinate or a trifluoromethylated-triazole as the ancillary ligand, were synthesized and characterized for applications in organic light-emitting diodes (OLEDs). D. function theory (DFT) calculations showed that these iridium complexes had a wide band gap, owing to the introduction of the strong electron withdrawing perfluoro carbonyl group. Time-dependent DFT (TD-DFT) calculations suggested that their lowest triplet excited state was dominated by a HOMO → LUMO transition and that the contribution of the metal-to-ligand charge transfer (MLCT) was higher than 34% for all four complexes, indicating that strong spin-orbit coupling exists in the complexes. The 10 wt % (TF)2Ir-(pic) doped 9-(3-(9H-carbazole-9-yl)-phenyl)-3-(dibromophenylphosphoryl)-9H-carbazole (mCPPO1) film exhibited the highest photoluminescence quantum yield of 74 ± 3% among the films based on the four complexes. Phosphorescent OLEDs based on (TF)2Ir-(pic) and (TF)2Ir-(fptz) exhibited maximum external quantum efficiencies of 17.1% and 8.4% and Commission Internationale de l’Eclairage (CIE) coordinates of (0.141, 0.158) and (0.147, 0.116), resp. These CIE coordinates represent some of the deepest blue emissions ever achieved from phosphorescent OLEDs with considerably high EQEs.

Journal of the American Chemical Society published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Sohn, Sunyoung’s team published research in Molecular Crystals and Liquid Crystals in 676 | CAS: 219508-27-7

Molecular Crystals and Liquid Crystals published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C12H15NO, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Sohn, Sunyoung published the artcileSynthesis and characterization of heptaflurosulfonyl-substituted iridium complexes for blue phosphorescent organic light emitting diodes, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Molecular Crystals and Liquid Crystals (2018), 676(1), 83-94, database is CAplus.

We synthesized the heptaflurosulfonyl-substituted iridium complexes with SOCF7pic, SOCF7mpic, and SOCF7taz as a dopants for blue phosphorescent organic light emitting diodes (PHOLEDs). The SOCF7pic, SOCF7mpic, and SOCF7taz showed high thermal stability with thermal decomposition temperature of 395, 396, and 411 °C by the TGA measurement. Using newly synthesized dopants, blue emissive PHOLEDs were fabricated by using co-host materials during vacuum process. The devices with SOCF7pic or SOCF7mpic dopant exhibited similar current efficiencies (1.55 cd/A vs. 1.25 cd/A) and power efficiencies (1.24 lm/W vs. 1.0 lm/W). It showed relatively higher than the SOCF7taz doped device efficiencies with 1.0 cd/A and 0.6 lm/W. The high efficiencies of the SOCF7pic and SOCF7mpic doped devices compared with the SOCF7taz doped device are caused by the improved electrons and holes injection into the emitting layer with well-aligned HOMO-LUMO levels or relatively uniform surface morphol.

Molecular Crystals and Liquid Crystals published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C12H15NO, Recommanded Product: 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Jang, Jae-Ho’s team published research in Synthetic Metals in 203 | CAS: 219508-27-7

Synthetic Metals published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Jang, Jae-Ho published the artcileBlue-green phosphorescent imidazole-based iridium(III) complex with a broad full width at half maximum for solution-processed organic light-emitting diodes, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, the publication is Synthetic Metals (2015), 180-186, database is CAplus.

A blue-green phosphorescent Ir(III) complex was designed and synthesized for solution-processed organic LEDs (OLEDs), (DMDPI)2Ir(tftap), that contains 1,2-dimethyl-4,5-diphenyl-1H-imidazole (DMDPI) as the main ligand and 2-(3-(trifluoromethyl)-1H-1,2,4-triazol-5-yl)pyridine (tftap) as an ancillary ligand. (DMDPI)2Ir(tftap) showed good solubility in common organic solvents such as CH2Cl2, CHCl3, toluene, and chlorobenzene. The luminescence (PL) of (DMDPI)2Ir(tftap) showed a maximum emission peak (λmax) of 532 nm in CH2Cl2 solution The HOMO and LUMO levels of (DMDPI)2Ir(tftap) are -5.36 and -2.76 eV, resp. Solution-processed blue-green OLEDs were fabricated based on (DMDPI)2Ir(tftap) with an ITO/PEDOT:PSS (30 nm)/26DCzPPy:(DMDPI)2Ir(tftap) (11%) (40 nm)/TPBi (60 nm)/CsF (1 nm)/Al structure. The electroluminescent (EL) spectra of (DMDPI)2Ir(tftap) exhibited a maximum emission peak at 522 nm with a broad full-width at half-maximum (FWHM) of 115 nm and Commission Internationale de L’Eclairage (CIE) coordinates of (0.33, 0.54) at 1000 cd m-2. The device with 11% doping concentration of (DMDPI)2Ir(tftap) exhibited a maximum luminance of 6304 cd m-2, a maximum luminous efficiency of 7.14 cd A-1, a power efficiency of 3.63 lm W-1, and an external quantum efficiency of 2.59%. White-emitting devices containing a single emissive layer consisting of PVK as a polymer host, (DMDPI)2Ir(tftap) as a blue-green dopant, and (PIQ)2Ir(acac) as a red dopant were fabricated. These devices exhibited CIE coordinates of (0.42, 0.48) at 1000 cd m-2, which are close to the standard warm white-light CIE coordinates of (0.44, 0.40).

Synthetic Metals published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Safety of 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Michlewska, Sylwia’s team published research in European Polymer Journal in 87 | CAS: 219508-27-7

European Polymer Journal published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Quality Control of 219508-27-7.

Michlewska, Sylwia published the artcileRuthenium metallodendrimers with anticancer potential in an acute promyelocytic leukemia cell line (HL60), Quality Control of 219508-27-7, the publication is European Polymer Journal (2017), 39-47, database is CAplus.

Ruthenium belongs to the family of metals widely used in anticancer therapy (platinum, arsenic, antimony, bismuth, gold, vanadium, iron, rhodium, titanium, gallium). This paper deals with a new kind of ruthenium terminated carbosilane dendrimers (CRD), consisting of carbosilane dendrons functionalized with N-, NH2-donor monodentate and N,N-chelating ruthenium complexes. The biophys. characterization, hemolytic activity and the cytotoxicity towards cancer (HL-60) and normal (B-14) cell lines of CRDs have been determined The data indicate that: (1) generation 0 metallodendrimers are the most effective drugs, being non-toxic for normal cells but induced significant cytotoxicity (>90%) in cancer cells; (2) an increase of generation leads both increased cytotoxicity of CRDs and the leveling of the difference in their action on normal and cancer cells; (3) coordination modes of ruthenium in a dendrimer scaffold did not correlate with their cytotoxicity towards normal and cancer cells. Results suggest that ruthenium dendrimers can be considered as alternative anticancer therapeutic agent.

European Polymer Journal published new progress about 219508-27-7. 219508-27-7 belongs to triazoles, auxiliary class Trifluoromethylated Building Blocks, name is 2-[5-(Trifluoromethyl)-1H-1,2,4-triazol-3-yl]pyridine, and the molecular formula is C8H5F3N4, Quality Control of 219508-27-7.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics