Tag: M.W:200-300

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 7411-23-6 as follows. 7411-23-6

Intermediate 11 -l-(2-methylallyl)-lH-l,2,4-triazole To 3,5-dibromo-lH-l,2,4-triazole (1.5 g, 6.61 mmol) in DMF (13 mL) was added sodium tert- pentoxide (0.728 g, 6.61 mmol) and the mixture was stirred for 10 min at rt under nitrogen atmosphere. 3-Bromo-2-methylprop-l-ene (0.667 mL, 6.61 mmol) was added and the mixture was stirred at 40C for 2 hours. The mixture was poured onto water and extracted with diisopropylether (2x). The organic phase was washed with water (2x), brine and dried over sodium sulfate. The solvents were evaporated to give the title compound as a liquid (1.70 g, 91%). GCMS (CI) m/z 281 [M+]. XH NMR (400 MHz, CDCI3) delta ppm 1.74 (d, 3 H) 4.69 (s, 2 H) 4.81 – 4.86 (m, 1 H) 5.05 (dd, 1 H).

According to the analysis of related databases, 7411-23-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; ACTURUM LIFE SCIENCE AB; BESIDSKI, Yevgeni; YNGVE, Ulrika; PAULSEN, Kim; LINDE, Christian; MALMBORG, Jonas; WO2014/195322; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

423165-07-5, Name is exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane, 423165-07-5, belongs to Triazoles compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows.

The amine of formula VII (0.29 g, 1.25 mmol), alcohol of formula XVII (0.45 g, 1.2 equivalents), [Cp*lrl2]2(0.036 g, 2.5 mol%), sodium iodide (0.019 g, 5 mol%) and molecular sieves (0.75 g) were suspended in 10 ml of toluene at the room temperature, the reaction mixture was bubbled (2 to 5 min) with argon and closed with a septum. The reaction mixture was heated up to 120C and stirred for 24 hours. Then, the mixture was cooled down to 50C, activated carbon (Norit A, 0.03 g) was added and the suspension was stirred for 15 minutes. The suspension was filtered through kieselguhr and washed with dichloromethane (30 ml). Removal of the solvent by distillation at a reduced pressure provided a crude mixture containing 67.8 % of Maraviroc of formula I (determined by UPLC).

Statistics shows that exo-3-(3-Isopropyl-5-methyl-4H-1,2,4-triazol-4-yl)-8-azabicyclo[3.2.1]octane is playing an increasingly important role. we look forward to future research findings about 423165-07-5.

Reference:
Patent; ZENTIVA, K.S.; CERNA, Igor; HAJICEK Josef; WO2014/173375; (2014); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

7411-23-6, Adding some certain compound to certain chemical reactions, such as: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7411-23-6.

To a solution of 3,5-dibromo-1H-1,2,4-triazole (10.0 g, 44.1 mmol) in DMF (75 mL) and potassium carbonate (12.2 g, 88.2 mmol) was added iodomethane (3.02 mL, 48.5 mmol) in one portion. This gave rise to a strong exotherm from 17 C to 38 C after one minute. The reaction mixture was stirred overnight, diluted with 150 mL of EtOAc and then filtered to remove most of the inorganics. The solvent was removed under reduced pressure and the resultant yellow oily solid was partitioned between EtOAc (250 mL) and water (100 mL) and the aqueous washed with EtOAc (150 mL). The combined organics were washed with washed with brine (50 mL), dried over magnesium sulfate, filtered and the solvent removed in vacuo to give 3,5-dibromo-1-methyl-1,2,4-triazole (6.2 g, 25.8 mmol, 58% yield) as a yellow solid. UPLC-MS (ES+, Method A): 1.79 min, m/z 241.7 [M+H]+.1H NMR (400 MHz, DMSO-d6) delta 3.83 (3H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7411-23-6.

Reference:
Patent; REDX PHARMA PLC; JONES, Clifford, D.; BUNYARD, Peter; PITT, Gary; BYRNE, Liam; PESNOT, Thomas; GUISOT, Nicolas, E.S.; (318 pag.)WO2019/145729; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common compound: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below. 7411-23-6

a 3,5-Dibromo-1-(4-methoxyphenylmethyl)-1H-1,2,4-triazole 4-Methoxyphenylmethyl chloride (4.47 ml) was added to a stirred solution of 3,5-dibromo-1,2,4-triazole (7.125 g) and triethylamine (4.81 ml) in anhydrous dichloromethane (70 ml) at room temperature. After 4 days, the mixture was evaporated under reduced pressure and the residue purified by column chromatography over silica, eluding with ethyl acetate/isohexane (1:4) to give the sub-title compound (7.34 g) as a solid. MS (+ve APCI) 346/348/350 ((M+H)+).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 7411-23-6, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Bantick, John; Ingall, Anthony; Perry, Matthew; Reynolds, Rachel; US2004/14634; (2004); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Some common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, molecular formula is C2HBr2N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 7411-23-6

NaH (60% dispersion in mineral oil; 5.29 g, 132 mmol) was added to a stirred solution of 3,5-dibromotriazole (20.0 g, 88.2 mmol) in DMF under an atmosphere of N2 at r.t. After 30 min, 2-iodopropane (10.6 ml, 106 mmol) was slowly added and the r.m. was heated at 40 C. for 2-3 h. The content was carefully poured onto ice/H2O (1 l), and the mixture was extracted with DIPE. The combined organic extracts were washed with H2O (4¡Á200 ml), then with brine and dried (Na2SO4). Filtration and concentration under reduced pressure yielded a yellow oil. Yield: 16.50 g of intermediate 24 (70%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 7411-23-6, its application will become more common.

Reference:
Patent; Van Brandt, Sven Franciscus Anna; De Cleyn, Michel Anna Jozef; Gijsen, Henricus Jacobus Maria; Berthelot, Didier Jean-Claude; Surkyn, Michel; US2012/295891; (2012); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 7411-23-6

To a stirred solution of N,N-diisopropylethylamine (5.7 mL, 33.0 mmol), bromotripyrrolidinophosphonium hexafluorophosphate (5.14 g, 11.02 mmol) and pyridine oxide (1.05 g, 11.0 mmol) in DCM (25 mL) at r.t under nitrogen was added 3,5-dibromo-1H-1,2,4-triazole (0.08 mL, 11.02 mmol) in a single portion and the reaction stirred at 25 C overnight. The solvents were removed in-vacuo and the residue partitioned between 50 mL of DCM and 35 mL of water, passed through a phase separation cartridge and concentrated in-vacuo. The crude material was purified by column chromatography (SiO2) eluting with 10-60% EtOAc in Pet. Ether to give 2-(3,5-dibromo-1,2,4-triazol-1-yl)pyridine (1.95 g, 6.4 mmol, 58 % yield) as a white crystalline solid. Intermediate 8: UPLC-MS (ES+, Method A): 1.53 min, m/z 304.9 [M+H]+.1H NMR (400 MHz, DMSO-d6) delta 8.66 (ddd, J = 4.7, 1.9, 0.8 Hz, 1H), 8.15 (td, J = 7.8, 1.9 Hz, 1H), 7.82 (dt, J = 8.1, 1.0 Hz, 1H), 7.66 (ddd, J = 7.5, 4.9, 1.0 Hz, 1H). Structure confirmed by DEPT NMR. A second compound was isolated to give 4-(3,5-dibromo-1,2,4-triazol-1-yl)pyridine (120 mg, 0.40 mmol, 3.6% yield). Intermediate 9: UPLC-MS (ES+, Method A): 1.33 min, m/z 304.9 [M+H]+.1H NMR (400 MHz, DMSO-d6) delta 8.93-8.80 (m, 2H), 7.82-7.74 (m, 2H). Structure confirmed by DEPT NMR

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7411-23-6.

Reference:
Patent; REDX PHARMA PLC; JONES, Clifford, D.; BUNYARD, Peter; PITT, Gary; BYRNE, Liam; PESNOT, Thomas; GUISOT, Nicolas, E.S.; (318 pag.)WO2019/145729; (2019); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

A common heterocyclic compound, 956317-36-5, name is 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid, molecular formula is C10H9N3O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 956317-36-5.

To a stirred solution of 7(184 mg,0.86 mmol) in DMF (5 ml) was added 92) (174 mg, 0.86 mmol), EDCI (198 mg, 1.03 mmol), HOAt (140 mg, 1.03 mmol), and N-methylmorpholine(0.5 ml, 4.30 mmol), the resulting mixture was stirred for 16 h at room temperature. The reaction mixture was diluted with EtOAc, sat.NaHCO3 aq, and organic phase was separated, the aqueous mixture was extracted with EtOAc. The organic phase and extracts were combined, dried over Na2SO4, and concentrated in vacuo. The residue was chromatographed on SiO2(Hexane- EtOAc = 2 : 1) to give 8 (300mg,87%) as a colorless oil. The 1H NMR and 13C NMR data for this compound was extremely complicated due to its existence as rotamers.1H NMR (500 MHz, CDCl3):delta 7.92-7.75 (3H, m), 7.33-7.10 (2H, m), 4.87-2.90 (7H, m), 2.41 (3H, s),2.19-1.88 (1H, m), 1.71-1.37 (10H, m), 1.31-1.10 (3H, m); 13C NMR(125 MHz, CDCl3): delta 169.59, 169.43, 168.98, 168.76, 154.89, 154.69,154.44, 138.16, 138.11, 137.81, 135.36, 135.24, 133.65, 133.57, 133.30, 130.12,129.52, 129.44, 129.03, 128.93, 128.27, 128.11, 127.95, 122.22, 122.13, 121.90,121.83, 79.54, 79.39, 52.02, 51.30, 48.16, 47.53, 46.39, 46.16, 45.49, 45.10,44.76, 44.41, 43.40, 42.96, 42.43, 42.03, 41.53, 41.16, 39.44, 36.85, 36.40,35.81, 35.02, 34.76, 34.47, 33.89, 29.40, 28.24, 28.16, 20.73, 20.67, 19.76,19.5517.96, 17.57, 17.33, 16.67; IR (neat): 1683, 1635 cm-1; MS (EI)m/z 399 (M+);HRMS (EI) calcd for C21H29N5O3:399.2270 (M+), found: 399.2273; [alpha]17 D -34.9 (c0.9, CHCl3).

The synthetic route of 5-Methyl-2-(2H-1,2,3-triazol-2-yl)benzoic acid has been constantly updated, and we look forward to future research findings.

Reference:
Article; Minehira, Daisuke; Takahara, Satoyuki; Adachi, Isao; Toyooka, Naoki; Tetrahedron Letters; vol. 55; 42; (2014); p. 5778 – 5780;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

7411-23-6, A common compound: 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, belongs to Triazoles compound, it can change the direction of chemical reaction, and react with certain compounds to generate new functional products. A new synthetic method of this compound is introduced below.

Into a 250-mL round-bottom flask, was placed 3,5-dibromo-lH-l,2,4-triazole (5 g, 22.04 mmol, 1.00 equiv) in N,N-dimethylformamide (25 mL) and potassium carbonate (9 g, 65.12 mmol, 3.00 equiv). This was followed by the addition of SEMC1 (4.43 g, 26.53 mmol, 1.20 equiv) dropwise with stirring at 0 C. The resulting mixture was stirred overnight at 25 C. The resulting solution was diluted with 100 mL of EA, washed with 5 x 100 mL of saturated brine and concentrated. The residue was applied onto a silica gel column and eluted with ethyl acetate/petroleum ether (1/10). This resulted in 7.26 g (92%) of 3,5-dibromo-l-((2- (trimethylsilyl)ethoxy)methyl)-lH-l,2,4-triazole as yellow oil. MS (ES, m/z) [M+H]+: 356, 358, 360.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3,5-Dibromo-1H-1,2,4-triazole, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; THE ROCKEFELLER UNIVERSITY; BRESLOW, Jan L.; PONDA, Manish P.; SELNICK, Harold; EGBERTSON, Melissa; (61 pag.)WO2017/123518; (2017); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

7411-23-6, The chemical industry reduces the impact on the environment during synthesis 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, I believe this compound will play a more active role in future production and life.

To a solution of 2 (15 g, 66.1 mmol) in acetonitrile(80 mL) was slowly added N,N-diisopropylethyamine(8.0 g, 61.9 mmol) followed by benzyl bromide(12.4 g, 5.8 mmol) in dimethyl foramide (15 mL). It was stirred for 12 h at 80C. Progress of the reaction was monitored by TLC. After completion of the reaction, volatiles were evaporated under reduced pressure. Into the residue, water was added and the reaction mass extracted with dichloromethane(3¡Á100 mL). Combined organic phase was dried over anhydrous magnesium sulphate, concentrated todryness and further purified by column chromatography to afford 6 as a white solid (18 g,80% yield). m.p. 67.4-68; IR (KBr): 3088, 2948,1586, 14.96, 1453, 1434, 1416, 1259, 1059 cm-1;1H NMR (400 MHz, CDCl3): 5.32 (s, 2H), 7.31-7.39(m, 5H); 13C NMR (100 MHz, CDCl3): 53.7, 128.0,128.8, 129.0, 129.4, 133.6, 140.3 (1H and 13C patterns match with the litereature value)22.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dibromo-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Article; Roy, Bhairab Nath; Singh, Girij Pal; George, Shaji K.; Lathi, Piyush S.; Agrawal, Manoj K.; Trivedi, Anurag; Mishra, Madhan; Singh, Gajendra; Indian Journal of Chemistry – Section B Organic and Medicinal Chemistry; vol. 53; 5; (2014); p. 610 – 618;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

These common heterocyclic compound, 7411-23-6, name is 3,5-Dibromo-1H-1,2,4-triazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. 7411-23-6

In a 250 mL round bottomed flask sodium hydride (60% dispersion in mineral oil) (264 mg, 6.61 mmol) was added to a colorless solution of 3,5-dibromo-1H-1,2,4-triazole (Int-1, 1 g, 4.41 mmol) in DMF (22 ml). The resulting suspension was stirred at room temp during 30 min and 3-(bromomethyl)-3-methyloxetane (873 mg, 5.29 mmol) was added and the reaction was stirred at 40C over night.The reaction mixture was poured into 50 mL H20 and extracted with EtOAc (3 x 50 mL). The organic layers were washed with sat NaCl (3 x 50 mL), dried over MgS04 and concentrated in vacuo. The title compound was isolated as a colorless liquid (1.35 g, 98.5 % yield). MS (ES+) m/z: 311.9 [(M+H)+].

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 7411-23-6.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; BARTELS, Bjoern; BERCHTOLD, Stefan; GALLEY, Guido; GOERGLER, Annick; JAKOB-ROETNE, Roland; KRUMMENACHER, Daniela; LIMBERG, Anja; NEIDHART, Werner; RATNI, Hasane; REUTLINGER, Michael; RODRIGUEZ SARMIENTO, Rosa Maria; SCHNIDER, Christian; (309 pag.)WO2018/87018; (2018); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics