Tag: M.W=300-350

Yu, Shichong published the artcileSynthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14α-demethylase, Name: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, the publication is European Journal of Medicinal Chemistry (2010), 45(10), 4435-4445, database is CAplus and MEDLINE.

A series of 1-(1H-1,2,4-triazol-1-yl)-2-(2,4-difluorophenyl)-3-substituted-2-propanols, which are analogs of fluconazole, have been designed and synthesized as the potential antifungal agents by the click reaction. Click reaction approach toward the synthesis of two sets of novel 1,2,3-triazolyl linked triazole antifungal derivatives was achieved by Cu(I)-catalyzed 1,3-dipolar cycloaddition of propargylated intermediates with substituted benzyl or alkyl azides. The 1,2,3-triazolyl group was inserted into the side chain of the target mol. which can increase the antifungal activity of compounds

European Journal of Medicinal Chemistry published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C3H6O2, Name: 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Guan, Zhongjun published the artcileSynthesis, molecular docking, and biological evaluation of novel triazole derivatives as antifungal agents, Quality Control of 86386-77-8, the publication is Chemical Biology & Drug Design (2010), 76(6), 496-504, database is CAplus and MEDLINE.

Twenty-eight novel triazoles I (R = 2-FC₆H₄, 4-BrC₆H₄, 3-BrC₆H₄, etc.) and II [4-(MeOSO₂)C₆H₄, 4-(EtOSO₂)C₆H₄, 4-(i-PrOSO₂)C₆H₄, etc.] have been synthesized for structure-activity relationship studies as antifungal agents. The compounds were designed based on the structure of fluconazole and mol. modeling of the active site of the cytochrome P 450 14α-demethylase (CYP51). All of them are reported for the first time. Their chem. structures are characterized by ¹H NMR, ¹³C NMR, LC-MS, and elemental anal. The antifungal activities have been evaluated in vitro by measuring the minimal inhibitory concentrations Compounds I exhibited higher activity against nearly all fungi tested except Aspergillus fumigatus than fluconazole. The computational mol. docking experiments indicated that the inhibition of CYP51 involves a coordination bond with iron of the heme group, a hydrophilic H-bonding region, a hydrophobic region, and a narrow hydrophobic binding cleft.

Chemical Biology & Drug Design published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Mittapelli, Vasantha published the artcileIsolation/synthesis & characterization & potential impurities of antifungal drug, Fluconazole, Quality Control of 86386-77-8, the publication is Asian Journal of Biochemical and Pharmaceutical Research (2011), 1(4), 201-206, database is CAplus.

In the synthesis of Fluconazole in bulk [α-(2,4-difluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol] various impurities are formed. The synthesis of the target compounds was achieved by a literature synthesis or using fluconazole as a starting material. The present work details the isolation/synthesis and characterization of isomer impurity, triazole impurity and desfluoro impurity [i.e., α-(4-fluorophenyl)-α-(1H-1,2,4-triazol-1-ylmethyl)-1H-1,2,4-triazole-1-ethanol].

Asian Journal of Biochemical and Pharmaceutical Research published new progress about 86386-77-8. 86386-77-8 belongs to triazoles, auxiliary class Epoxides,Triazole,Fluoride,Salt,Sulfonic acid,Benzene, name is 1-((2-(2,4-Difluorophenyl)oxiran-2-yl)methyl)-1H-1,2,4-triazole methanesulfonate, and the molecular formula is C12H13F2N3O4S, Quality Control of 86386-77-8.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

Xu, Liang-Zhong published the artcileSynthesis, crystal structure, and biological activities of 1-((5-(4-(4-chlorophenoxy)-2-chlorophenyl)-2,2,3-trimethyloxazolidin-5-yl)methyl)-1H-1,2,4-triazole, Computed Properties of 136815-80-0, the publication is Chinese Journal of Structural Chemistry (2008), 27(11), 1365-1369, database is CAplus.

The title compound 1-((5-(4-(4-chlorophenoxy)-2-chlorophenyl)-2,2,3-trimethyl-oxazolidin-5-yl) methyl)-1H-1,2,4-triazole (C₂₁H₂₂Cl₂N₄O₂) was synthesized and characterized by elemental anal., IR, ¹H NMR, MS and single-crystal X-ray diffraction. The crystal belongs to the triclinic system, space group P1̅ with a = 6.891(2), b = 9.074(2), c = 18.258(4) Å, α = 99.292(4), β = 95.105(4), γ = 108.068(3)°, C₂₁H₂₂Cl₂N₄O₂, M_r = 433.33, V = 1059.3(4) ų, Z = 2, D_c = 1.359 g/cm³, F(000) = 452, μ = 0.331 mm^-1, the final R = 0.0448 and wR = 0.0994 for 3727 unique reflections. The dihedral angle between the oxazolidine ring taking an envelope conformation with a local pseudo-mirror and the triazole ring is 27.7(9)°. Weak intermol. C-H…N hydrogen bonds and π-π interactions exist between the triazole rings of neighboring mols., forming a three-dimensional network, which stabilizes the crystal structure. The primary biol. test shows the target compound has certain fungicidal activity.

Chinese Journal of Structural Chemistry published new progress about 136815-80-0. 136815-80-0 belongs to triazoles, auxiliary class Triazoles, name is 1-(2-Chloro-4-(4-chlorophenoxy)phenyl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-one, and the molecular formula is C10H18O4, Computed Properties of 136815-80-0.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics