Tag: M.W=300-400

A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 4979-32-2, Name is S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine, molecular formula is C19H26N2S2. In an article, author is Sari, Anissa Nofita,once mentioned of 4979-32-2, SDS of cas: 4979-32-2.

Identification and Characterization of Mortaparib(Plus)-A Novel Triazole Derivative That Targets Mortalin-p53 Interaction and Inhibits Cancer-Cell Proliferation by Wild-Type p53-Dependent and -Independent Mechanisms

Simple Summary Functional inactivation of tumour suppressor protein p53 is frequently found in a large variety of cancers. One of the mechanisms by which p53 is inactivated is through its interaction with mortalin protein that inhibits its translocation, and hence the function, in the nucleus. Abrogation of mortalin-p53 interaction has been suggested as a target for cancer therapy. We report here a novel multimodal small molecule, called Mortaparib(Plus), that causes growth arrest or apoptosis of cancer cells by abrogating mortalin-p53 interaction yielding reactivation of p53 function. It also causes upregulation of tumour suppressor protein p73, and inactivation of PARP1 and CARF proteins accounting for its multimodal anticancer activity. p53 has an essential role in suppressing the carcinogenesis process by inducing cell cycle arrest/apoptosis/senescence. Mortalin/GRP75 is a member of the Hsp70 protein family that binds to p53 causing its sequestration in the cell cytoplasm. Hence, p53 cannot translocate to the nucleus to execute its canonical tumour suppression function as a transcription factor. Abrogation of mortalin-p53 interaction and subsequent reactivation of p53’s tumour suppression function has been anticipated as a possible approach in developing a novel cancer therapeutic drug candidate. A chemical library was screened in a high-content screening system to identify potential mortalin-p53 interaction disruptors. By four rounds of visual assays for mortalin and p53, we identified a novel synthetic small-molecule triazole derivative (4-[(1E)-2-(2-phenylindol-3-yl)-1-azavinyl]-1,2,4-triazole, henceforth named Mortaparib(Plus)). Its activities were validated using multiple bioinformatics and experimental approaches in colorectal cancer cells possessing either wild-type (HCT116) or mutant (DLD-1) p53. Bioinformatics and computational analyses predicted the ability of Mortaparib(Plus) to competitively prevent the interaction of mortalin with p53 as it interacted with the p53 binding site of mortalin. Immunoprecipitation analyses demonstrated the abrogation of mortalin-p53 complex formation in Mortaparib(Plus)-treated cells that showed growth arrest and apoptosis mediated by activation of p21(WAF1), or BAX and PUMA signalling, respectively. Furthermore, we demonstrate that Mortaparib(Plus)-induced cytotoxicity to cancer cells is mediated by multiple mechanisms that included the inhibition of PARP1, up-regulation of p73, and also the down-regulation of mortalin and CARF proteins that play critical roles in carcinogenesis. Mortaparib(Plus) is a novel multimodal candidate anticancer drug that warrants further experimental and clinical attention.

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Synthetic Route of 4979-32-2, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4979-32-2, Name is S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine, SMILES is N(C1CCCCC1)(C2CCCCC2)SC3=NC4=CC=CC=C4S3, belongs to Triazoles compound. In a article, author is Tian, Ye, introduce new discover of the category.

HOMO-controlled donor-acceptor contained polyimide for nonvolatile resistive memory device

Molecular orbital energy level plays a vital role in the storage performance of memory materials. Fixing LUMO levels, reasonable regulation of HOMO level can effectively optimize the memory behaviors of storage devices. Therefore, two triazole-based donor-acceptor contained polyimides (TZMPDA-6FDA, TZAPDA-6FDA) with similar LUMO levels but different HOMO levels are designed and synthesized by introducing the pendant groups with different electron-donating ability. The LUMO levels of TZMPDA-6FDA and TZAPDA-6FDA are-1.98 and 1.99 eV, respectively. In comparison with TZMPDA-6FDA, the HOMO level of TZAPDA-6FDA increased from 5.32 to -5.23 eV due to the stronger electron-donating ability of diethylamino group than methoxy group. The increased HOMO level can reduce the energy barriers for charge carriers injection and migration, and thus effectively decrease the threshold voltage of memory devices from -2.4 to-1.8 V. The high-lying HOMO levels can facilitate the intraand inter-molecular charge transfer, which benefit to optimize the performance of the memory device.

Synthetic Route of 4979-32-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 4979-32-2 is helpful to your research.

Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4979-32-2, Name is S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine, molecular formula is C19H26N2S2, belongs to Triazoles compound. In a document, author is Steppeler, Franz, introduce the new discover, Recommanded Product: S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine.

Synthesis of terminal alkynes based on (1S,3R,4R)- and (1S,3S,4R)-2-azabicyclo[2.2.1]heptane

Two approaches to terminal alkynes based on the enantiomerically pure epimers (1S,3R,4R)- and (1S,3S,4R)-2-azabicyclo[2.2.1]heptane aldehydes were established: i) a non-Wittig route through a dichloroalkene intermediate; and, ii) a Corey-Fuchs approach via dibromoalkene. Among various organometallic reagents tested, the use of n-butyllithium was efficient. The resulting alkynes were fully characterized, and one epimer was used in a click chemistry triazole synthesis. For one of the products containing a bulky N-Boc-proline substituent, the existence of atropisomers was observed. The absolute stereochemistry was determined by electronic circular dichroism spectroscopy (ECD) and optical rotation supported by quantum chemical simulations.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law. In my other articles, you can also check out more blogs about 4979-32-2. Recommanded Product: S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine.

4979-32-2, Name is S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine, molecular formula is C19H26N2S2, belongs to Triazoles compound, is a common compound. In a patnet, author is Osmanov, V. K., once mentioned the new application about 4979-32-2, Safety of S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine.

4-Phenyl-5-(2-Thienylmethyl)-2,4-Dihydro-3H-1,2,4-Triazole-3-Selone and 3,3′-Di[4-Phenyl-5-(2-Thienylmethyl)-4H-1,2,4-Triazolyl] Diselenide: Synthesis, Structures, and Biocidal Properties

Three new organoselenium compounds are synthesized: N-phenyl-2-(2-thienylacetyl)hydrazinecarboselenoamide (I), 4-phenyl-5-(2-thienylmethyl)-2,4-dihydro-3H-1,2,4-triazole-3-selone (II), and 3,3′-di[4-phenyl-5-(2-thienylmethyl)-4H-1,2,4-triazolyl] diselenide (III). Two of them (compounds II and III) are characterized by X-ray diffraction analysis (CIF files CCDC nos. 1956602 (II) and 1956603 (III)). Compound II crystallizes in the monoclinic crystal system (space group P2(1)/n) with two crystallographically independent molecules A and B being different conformers relative to rotation about the N-Trz-C-Trz-C(H-2)-C-Tph bond, where Trz is triazole and Tph is thiophene (gauche-A (51.4(3)degrees) and cis-B (4.2(4)degrees)). In the crystal of compound II, molecules A and B form chains along the crystallographic axis a due to strong hydrogen bonds N-H center dot center dot center dot Se. Then the chains are bound into a three-dimensional framework via intermolecular nonvalent interactions Se center dot center dot center dot S (3.3857(11) angstrom). Owing to the anomeric effect, diselenide III is characterized by the typical gauche conformation of the substituents at the Se-Se bond (torsion angle CSeSeC 83.5(4)degrees) stabilized by a weak intramolecular hydrogen bond C-H center dot center dot center dot pi. In the crystal of compound III, the molecules form chains along the crystallographic acid b due to intermolecular noncovalent interactions Se center dot center dot center dot pi(C-C) (3.404(6) and 3.458(12) angstrom), Se center dot center dot center dot Se (3.8975(11) angstrom), and S center dot center dot center dot N (3.250(5) angstrom). Bactericidal and fungicidal activity of the synthesized compounds is studied.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 4979-32-2. The above is the message from the blog manager. Safety of S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine.

Reference of 4979-32-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 4979-32-2, Name is S-(Benzo[d]thiazol-2-yl)-N,N-dicyclohexylthiohydroxylamine, SMILES is N(C1CCCCC1)(C2CCCCC2)SC3=NC4=CC=CC=C4S3, belongs to Triazoles compound. In a article, author is Yadeghari, Adeleh, introduce new discover of the category.

Synthesis of a magnetic sorbent and its application in extraction of different pesticides from water, fruit, and vegetable samples prior to their determination by gas chromatography-tandem mass spectrometry

In this investigation, an efficient sorbent based on Fe3O4@polyphenols magnetic nanoparticles has been prepared using the extract of Mentha piperita leaves for the first time. The main purposes of this study were synthesis of economically affordable and environmentally friendly sorbent using the extract of Mentha piperita leaves and evaluating its application as a sorbent in magnetic solid phase extraction. The functional groups, magnetic property, size, and shape of the synthesized sorbent were characterized. The sorbent was utilized for the extraction and preconcentration of various pesticides (chlorpyrifos, fenazaquin, penconazole, diniconazole, oxadiazon, haloxyfop-methyl, hexaconazole, clodinafop-propargyl, tebuconazole, and fenoxaprop-p-ethyl) from vegetable, fruit, and water samples. After magnetic solid phase extraction, a dispersive liquid-liquid microextraction method was done to achieve low detection limits. The enriched pesticides were monitored by gas chromatography-tandem mass spectrometry. The synthesized sorbent was characterized by Fourier transform infrared, scanning electron microscopy, energy-dispersive x-ray spectroscopy, x-ray diffraction, and vibrating sample magnetometer techniques, which confirmed the successful synthesis of the magnetic nanoparticles. The effective parameters such as the sorbent weight, ionic strength, pH, vortex time, and kind and volume of elution and extraction solvents were studied. Under optimum extraction conditions, the method showed broad linear ranges (0.05-10 0 0 mu g L-1 ) with low limits of detection (0.27-4.13 ng L-1 ) and quantification (0.91-13.8 ng L-1). Extraction recoveries and enrichment factors were in the ranges of 54-89 % and 491-811, respectively. (C) 2020 Elsevier B.V. All rights reserved.

Reference of 4979-32-2, Consequently, the presence of a catalyst will permit a system to reach equilibrium more quickly, but it has no effect on the position of the equilibrium as reflected in the value of its equilibrium constant.I hope my blog about 4979-32-2 is helpful to your research.

Reference of 107534-96-3, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 107534-96-3, name is 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below.

To an aqueous solution (3 mL) containing K2[PtCl4] (0.30 g, 0.72 mmol), reagent L (0.22 g, 0.72 mmol) in acetone (7 mL) was added under stirring. After 48 h, the settled bulky light-yellow precipitate was filtered out, sequentially washed with water and hexane, and dried in air. The yield based on reagent L was 91%.

The synthetic route of 3-((1H-1,2,4-Triazol-1-yl)methyl)-1-(4-chlorophenyl)-4,4-dimethylpentan-3-ol has been constantly updated, and we look forward to future research findings.

Reference:
Article; Khisamutdinov; Anpilogova; Shitikova; Murinov, Yu. I.; Russian Journal of Inorganic Chemistry; vol. 61; 12; (2016); p. 1530 – 1537; Zh. Neorg. Khim.; vol. 61; 12; (2016); p. 1591 – 1598,8;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1533519-85-5, These common heterocyclic compound, 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Take 8.0g of the purified product of compound (4) obtained in Example 3, 64ml of tetrahydrofuran, start stirring, warm up to T=30~35C, stir until dissolved; add 6.4g NBS, stir the reaction for 3~4h, the reaction is completed, and the temperature is reduced to T 05, add 40ml of toluene, add 40ml of purified water dropwise, the temperature is controlled not to exceed 7, drop it, stir for 10min, let stand for liquid separation; the organic phase is cooled to 05, add 3% hydrogen sulfite dropwise 40ml of sodium solution, keep the temperature below 10C, drop after completion, stir for 20min, stand for liquid separation, collect organic phase; warm to 1825C with camera, add 40ml of 7% sodium bicarbonate solution, stir for 10min, stand for liquid separation , Collect the organic phase, concentrate and dry to prepare the Recinade product, and test its purity to 99.940%.

Statistics shows that Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate is playing an increasingly important role. we look forward to future research findings about 1533519-85-5.

Reference:
Patent; Beijing Xinkaiyuan Pharmaceutical Technology Co., Ltd. Hainan Fen Corporation; Xia Zhongning; Wu Jin; Wang Shiwei; (10 pag.)CN111116500; (2020); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Application of 1533519-85-5, The chemical industry reduces the impact on the environment during synthesis 1533519-85-5, name is Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, I believe this compound will play a more active role in future production and life.

For the 250 ml reaction bottle B join the previous step product (4 g, 0.0118 muM), tetrahydrofuran (30 ml), tetramethyl piperidine (TEMPO, 0.2 g, 0.1 eq), oil bath 30 – 32 C heating and stirring, to dissolve to clarify. Batch by adding N – bromo succinimide (NBS, 3.2 g, 0 . 018 muM, 1.5 eq), temperature control not more than 35 C. Canada finishes, thermal insulation 30 – 32 C reaction 3 h. Detection of the raw material after the reaction is complete, stop heating, ice bath cooling. To be in reaches warm 0 – 5 C, batch by adding sodium sulfite aqueous solution quenching reaction, ethyl acetate extraction, anhydrous sodium sulfate drying, filtering, and concentration, drying, and the produced intermediate C crude product can be directly used for the next step reaction. Analysis of the sample through the column chromatography (200 – 300 mesh silica gel, eluent is dichloromethane: methanol=15:1) purification, to obtain white solid C.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-((4-(4-cyclopropylnaphthalen-1-yl)-4H-1,2,4-triazol-3-yl)thio)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Jingxin Pharmaceutical Co., Ltd.; Shanghai Jingxin Bio-pharmaceutical Co., Ltd.; Dai Xiangqian; Huang Yue; (17 pag.)CN107098866; (2017); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Synthetic Route of 31250-99-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 31250-99-4, name is 1-Trityl-1H-1,2,4-triazole, This compound has unique chemical properties. The synthetic route is as follows.

EXAMPLE 6 This Example illustrates the preparation of 1-trityl-3-bromo-1,2,4-triazole. A stirred solution of 1-trityl-1,2,4-triazole (15.55 g, prepared as described in Example 1) and N,N,N’,N’-tetramethylethylenediamine (5.8 g) in dry tetrahydrofuran (500 ml) was cooled to -70 C. under nitrogen and treated dropwise with n-butyllithium (37.5 ml, 1.6M in hexane). The deep-red solution was stirred at -70 C. for twenty minutes, then treated dropwise with a solution of bromine (10.4 g) in dry tetrahydrofuran (10 ml). The now brownish-yellow solution was allowed to warm to -20 C., quenched with 0.1M sodium thiosulphate solution (150 ml), and extracted with dichloromethane (500 ml). The organic layer was washed with water (4*100 ml), dried and evaporated. The residue was chromatographed on silica, using dichloromethane-ether (25:2) as eluant, to give 1-trityl-5-bromo-1,2,4-triazole (7.86 g, m.p. 239-241 C.). NMR (CDCl3):delta7.1-7.3(15H,m), 7.95(1H,s).

The chemical industry reduces the impact on the environment during synthesis 1-Trityl-1H-1,2,4-triazole. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 31250-99-4, name is 1-Trityl-1H-1,2,4-triazole, belongs to Triazoles compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 31250-99-4, Product Details of 31250-99-4

EXAMPLE 2 This Example illustrates the preparation of 1-trityl-1,2,4-triazole-5-carboxaldehyde. A solution of 1-trityl-1,2,4-triazole (62.2 g, prepared as described in Example 1) and N,N,N’,N’-tetramethylethylenediamine (23.2 g, 30 ml) in dry tetrahydrofuran (1 l) was cooled to -70 C. under nitrogen. n-Butyllithium (140 ml, 1.6M solution in hexane) was added dropwise, with stirring, at such a rate that the internal temperature was maintained below -60 C. The dark red solution was stirred at -70 C. for at least thirty minutes, treated dropwise with N,N-dimethylformamide (25 ml), allowed to warm to -30 C., then quenched with water (500 ml). The mixture was extracted with ethyl acetate (500 ml), containing a little dichloromethane if any solid precipitated. The extracts were washed with water (6*500 ml), dried over magnesium sulphate, evaporated under reduced pressure and the crude product triturated with ether-hexane (1:1, 150 ml) to give the title compound (60 g, m.p. 134-136 C.). This can be contaminated with 1,2,4-triazole itself, but subsequent stages are not adversly affected and the impurity can be removed at a later stage. NMR (CDCl3): delta7.1-7.4 (15H,m), 8.1(1H,s), 9.15(1H,s).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Zeneca Limited; US5393732; (1995); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics