Tag: M.W=450-500

Arujoe, Meeli’s team published research in Tetrahedron Letters in 58 | CAS: 1082951-62-9

Tetrahedron Letters published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Formula: C13H17ClF6N5O2P.

Arujoe, Meeli published the artcileComparison of various coupling reagents in solid-phase aza-peptide synthesis, Formula: C13H17ClF6N5O2P, the publication is Tetrahedron Letters (2017), 58(35), 3421-3425, database is CAplus.

Aza-peptides are promising drug leads, however extensive study of their properties is hampered by low yielding aza-peptide bond formation during conventional Fmoc SPPS. The kinetics of aza-peptide bond formation in the model peptide H-Ala-AzAla-Phe-NH2 was compared with various conventional amino acid activators. The reaction rates and yields were dependent on the activator structure. The reaction time of aza-peptide formation using oxyma-based agents was approx. 30 times longer than in typical peptide synthesis. Therefore, new activators are required to increase the reactivity of the activated amino acid to achieve effective acylation of the semicarbazide moiety during aza-peptide bond formation.

Tetrahedron Letters published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Formula: C13H17ClF6N5O2P.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

El-Faham, Ayman’s team published research in Chemistry – A European Journal in 15 | CAS: 1082951-62-9

Chemistry – A European Journal published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Application In Synthesis of 1082951-62-9.

El-Faham, Ayman published the artcileCOMU: A Safer and More Effective Replacement for Benzotriazole-Based Uronium Coupling Reagents, Application In Synthesis of 1082951-62-9, the publication is Chemistry – A European Journal (2009), 15(37), 9404-9416, S9404/1-S9404/34, database is CAplus and MEDLINE.

The authors describe a new family of uronium-type coupling reagents that differ in their iminium moieties and leaving groups. The presence of the morpholino group in conjunction with an oxime derivative, especially Et 2-cyano-2-(hydroxyimino)acetate (Oxyma), had a marked influence on the solubilities, stabilities, and reactivities of the reagents. Finally, the new uronium salt I (COMU) derived from Oxyma performed extremely well in the presence of only 1 equiv of base, thereby confirming the effect of the hydrogen bond acceptor in the reaction. I also showed a less hazardous safety profile than the benzotriazole-based HDMA and HDMB, which exhibited unpredictable autocatalytic decompositions Furthermore, the Oxyma moiety contained in I suggests a lower risk of explosion than in the case of the benzotriazole derivatives

Chemistry – A European Journal published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Application In Synthesis of 1082951-62-9.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics

El-Faham, Ayman’s team published research in Organic Letters in 9 | CAS: 1082951-62-9

Organic Letters published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Product Details of C13H17ClF6N5O2P.

El-Faham, Ayman published the artcileNovel proton acceptor immonium-type coupling reagents: Application in solution and solid-phase peptide synthesis, Product Details of C13H17ClF6N5O2P, the publication is Organic Letters (2007), 9(22), 4475-4477, database is CAplus and MEDLINE.

A novel proton acceptor coupling reagent (I) (X = CH, N; R1 = H, Cl) in a form of PF6– salt shows superiority to those described previously. The oxygen in the carbocation moiety confers more solubility to the reagent. Furthermore, it enhances coupling yields and decreases racemization, allowing the use of 1 equiv of base.

Organic Letters published new progress about 1082951-62-9. 1082951-62-9 belongs to triazoles, auxiliary class Active Esterification, name is 5-Chloro-1-((dimethyliminio)(morpholino)methyl)-1H-benzo[d][1,2,3]triazole 3-oxide hexafluorophosphate(V), and the molecular formula is C13H17ClF6N5O2P, Product Details of C13H17ClF6N5O2P.

Referemce:
https://en.wikipedia.org/wiki/1,2,3-Triazole,
Triazoles – an overview | ScienceDirect Topics