SDS of cas: 61-82-5. In 2020.0 CHEMISTRYSELECT published article about TRANSITION-METAL COMPOUNDS; DENSITY-FUNCTIONAL THEORY; MOLECULAR-STRUCTURES; DOCKING; MOLYBDENUM; INDOLES; MANNICH; BONDS in [El Sayed, Mardia T.] Natl Res Ctr, Chem Ind Res Div, Appl Organ Chem Dept, Dokki 12311, Egypt; [Sarhan, Alaadin E.] Natl Res Ctr, Pharmaceut Div, Therapeut Chem Dept, Dokki 12311, Egypt; [Ahmed, Entsar] Al Azhar Univ, Chem Dept, Fac Sci, Girls Branch, Cairo, Egypt; [Khattab, Reham R.] Natl Res Ctr, Chem Ind Res Div, Photochem Dept, Dokki 12311, Egypt; [Elnaggar, Mohamed] Univ Sharjah, Fac Sci, Chem Dept, Sharjah 27272, U Arab Emirates; [El-Messery, Shahenda M.] Mansoura Univ, Fac Pharm, Dept Organ Pharmaceut Chem, POB 35516, Mansoura, Egypt; [Shaldam, Moataz A.] Kafrelsheikh Univ, Fac Pharm, Dept Pharmaceut Chem, Kafr Al Sheikh 33516, Egypt; [Hassan, Ghada S.] Mansoura Univ, Fac Pharm, Dept Med Chem, Mansoura 35516, Egypt in 2020.0, Cited 39.0. The Name is 1H-1,2,4-Triazol-5-amine. Through research, I have a further understanding and discovery of 61-82-5.
In the present investigation, some novel nitro Mannich bases derived from Michael type addition of activated nitro olefin, beta-nitrostyrene with various amines either primary or secondary including some amino sugars were designed and synthesized. The produced Mannich bases have been full characterized through different spectroscopic techniques. Antimicrobial evaluation has been performed against the Gram positive S. aureus and methicillin-resistant S. aurues (MRSA) infections. 5 of the synthesized compounds represent the best candidates in the biological screening, they have exhibited good activity with MIC values range from 100 to 250 mu g/ml. The active agents have been tested for pyruvate kinase inhibition activity with % of inhibition range from 30 to 79 % with IC50 in a nano molar range. They also exhibited significant Pyruvate kinase inhibition in nanomolar range with IC50 of 1066, 662, 1887, 418 and 1128 ng/ml, respectively (versus 196 ng/ml for AZD7545). Molecular docking calculations for active agents were performed. A complete conformational analysis molecular modeling utilizing Gaussian 09 program (HF/DFT) was used to verify the mode of bonding through the optimized geometries as well as essential quantum parameters were calculated using frontier energies (EHOMO & ELUMO) for the active candidates indicating the overall stability of the structure.
Welcome to talk about 61-82-5, If you have any questions, you can contact El Sayed, MT; Sarhan, AE; Ahmed, E; Khattab, RR; Elnaggar, M; El-Messery, SM; Shaldam, MA; Hassan, GS or send Email.. SDS of cas: 61-82-5
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics