Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics, Recommanded Product: 5445-51-2, 5445-51-2, Name is Cyclobutane-1,1-dicarboxylic acid, SMILES is OC(=O)C1(CCC1)C(O)=O, belongs to Triazoles compound. In a document, author is Asgari, Mohammad Sadegh, introduce the new discover.
Copper Supported onto Magnetic Nanoparticles as an Efficient Catalyst for the Synthesis of Triazolobenzodiazepino[7,1-b]quinazolin-11(9H)-ones via Click N-Arylation Reactions
A novel catalyst is designed and synthesized based on immobilization of copper onto modified magnetic nanoparticles. The catalyst was characterized by several characterization techniques. The catalyst was applied for the synthesis of a novel series of heterocyclic scaffold containing a 1,4-benzodiazepine fused with a 1,2,3-triazole ring and a quinazolin-11(9H)-one skeleton. The method is based on the direct synthesis of quinazolin-11(9H)-one ring by the reaction of isatoic anhydride (or anthranilic acid) and propargylamine, and an aldehyde, containing a leaving group on its aromatic ring. The reaction contains an in situ sequential click reaction of azide group with terminal alkyne and subsequent N-arylation reaction to afford the final products. The method benefits various advantages, such as regioselectivity and high yield of the products. The reusability of the catalyst was evaluated and the results showed that the catalyst is highly reusable in 10 sequential reactions.
A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 5445-51-2. Recommanded Product: 5445-51-2.