So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Robinson, Donovan J.; Spurlin, Sean P.; Gorden, John D.; Karimov, Rashad R. researched the compound: 6-Methylnicotinic acid( cas:3222-47-7 ).HPLC of Formula: 3222-47-7.They published the article 《Enantioselective Synthesis of Dihydropyridines Containing Quaternary Stereocenters Through Dearomatization of Pyridinium Salts》 about this compound( cas:3222-47-7 ) in ACS Catalysis. Keywords: dihydropyridine piperidine preparation enantioselective; pyridinium salt dearomatization rhodium BINAP catalyst. We’ll tell you more about this compound (cas:3222-47-7).
Enantioselective synthesis of non-aromatic heterocycles containing a quaternary stereogenic center is a challenging synthetic problem. A strategy towards this problem involving dearomatization of N-alkylpyridinium salts using boronic acid nucleophiles have been described. This dearomatization reaction is catalyzed by Rhodium(I)/BINAP catalyst and delivers dihydropyridines that contain a fully substituted stereogenic center alpha to the ring nitrogen atom in high yield and enantioselectivity. The reaction is compatible with a wide range of functional groups such as halide, ester, amide, olefin and free alc. Derivatization of dehydropyridine products allows synthesis of the functionalized tetrahydropyridines and piperidines.
Different reactions of this compound(6-Methylnicotinic acid)HPLC of Formula: 3222-47-7 require different conditions, so the reaction conditions are very important.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics