Recently I am researching about AGENTS; SAR; AMINOAZOLES; INHIBITORS, Saw an article supported by the V. N. Karazin Kharkiv National University [811H/12-17]. Published in TAYLOR & FRANCIS INC in PHILADELPHIA ,Authors: Kolosov, MA; Shvets, EH; Manuenkov, DA; Kulyk, OG; Mazepa, AV; Orlov, VD. The CAS is 61-82-5. Through research, I have a further understanding and discovery of 1H-1,2,4-Triazol-5-amine. Application In Synthesis of 1H-1,2,4-Triazol-5-amine
6-Functionalized 7-R-4,7-dihydro[1,2,4]azolo[1,5-a]pyrimidines (R = H or Me) were synthesized by Biginelli-like reaction of formaldehyde or acetaldehyde, aminoazoles, and corresponding beta-dicarbonyl precursor. Alkylation of the obtained compounds proceeds smoothly at position 4, while oxidation leads to 7-R-[1,2,4]azolo[1,5-a]pyrimidines formation. 6-Ethoxycarbonyl derivatives could be reduced to the corresponding alcohols by LiAlH4 and hydrolyzed to the acids. [GRAPHICS] .
Application In Synthesis of 1H-1,2,4-Triazol-5-amine. About 1H-1,2,4-Triazol-5-amine, If you have any questions, you can contact Kolosov, MA; Shvets, EH; Manuenkov, DA; Kulyk, OG; Mazepa, AV; Orlov, VD or concate me.
Reference:
Article; Safari, Niloufar; Shirini, Farhad; Tajik, Hassan; Journal of Molecular Structure; vol. 1201; (2020);,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics