So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Sheng, Chun Quan; Zhang, Wan Nian; Ji, Hai Tao; Song, Yun Long; Zhang, Min; Zhou, You Jun; Lu, Jia Guo; Zhu, Jue researched the compound: 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone( cas:86404-63-9 ).Formula: C10H7F2N3O.They published the article 《Design, synthesis and antifungal activity of novel triazole derivatives》 about this compound( cas:86404-63-9 ) in Chinese Chemical Letters. Keywords: chloroacetophenone reaction triazole; triazolyl acetophenone preparation epoxidation; oxirane triazolylmethyl difluorophenyl preparation reaction piperazine derivative; triazole diflurophenyl piperazinyl hydroxypropyl derivative preparation antifungal activity. We’ll tell you more about this compound (cas:86404-63-9).
Twenty-one 1-(1H-1,2,4-triazolyl)-2-(2,4-diflurophenyl)-3-(4-substituted-1-piperazinyl)-2-propanol derivatives were designed and synthesized, on the basis of the active site of lanosterol 14α-demethylase. In vitro antifungal activities showed that some of the target compounds had higher antifungal activity and broader antifungal spectrum than fluconazole.
Although many compounds look similar to this compound(86404-63-9)Formula: C10H7F2N3O, numerous studies have shown that this compound(SMILES:FC1=CC=C(C(CN2N=CN=C2)=O)C(F)=C1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.
Reference:
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics