Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 13273-53-5, name is 4-Bromo-1-methyl-1H-1,2,3-triazole, A new synthetic method of this compound is introduced below., Recommanded Product: 4-Bromo-1-methyl-1H-1,2,3-triazole
The crude was dissolved in 10ml of tetrahydrofuran /1.5mlDMF added potassium carbonate (1.14g, 8.30mmol), methyl iodide (471mg, 3.32mmol), 20 ~ 30 for 48 hours, 20ml of water and 20ml of ethyl acetate, layered aqueous layer was adjusted with hydrochloric acid, pH = 1-5, and extracted with 20ml of ethyl acetate, 40 concentrated under reduced pressure to 3ml, was cooled to 0 crystallization, filtration, 40 dried in vacuo to give 1-methyl -1H-1, 2,3-triazole-4-carboxylate 587mg, 50% yield.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; The Haiya Chemical Co., Ltd.; Jiang, Yueheng; Que, Limin; Xu, Jun; Qin, Dongguang; Cai, Tong; (17 pag.)CN105585534; (2016); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics