Related Products of 16681-70-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 16681-70-2 as follows.
[0430] IH-1,2,3-triazole-4-carboxylic acid (15.9 mg, 141f.tmol) and HATU (53.5 mg, 141 f.tmol) were dissolved in DMF (2 mL) and stirred for 15 minutes at room temperature.(2R,4R)-4-Amino-2-azido-5-(5′-chloro-2′-fluorobiphenyl-4-yl)pentanoic acid ethyl ester (50 mg, 128 f.tmol) and DIPEA(67 f.LL, 384 f.tmol) were added, and the mixture was stirred atroom temperature for 15 minutes then concentrated in vacuoand the residue was dissolved in EtOH (2 mL). An aqueoussolutionoflNNaOH (1.3 mL, 1.3 mmol)was added, and themixture was stirred at room temperature for 30 minutes thenconcentrated in vacuo and the residue was purified by reversephase chromatography to yield Compound 1 ( 45 mg).
According to the analysis of related databases, 16681-70-2, the application of this compound in the production field has become more and more popular.
Reference:
Patent; THERAVANCE BIOPHARMA R&D IP, LLC; Fleury, Melissa; Beausoliel, Anne-Marie; Hughes, Adam D.; Long, Daniel D.; Wilton, Donna A.A.; US2015/210690; (2015); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics