In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 288-36-8, name is 1H-1,2,3-Triazole belongs to Triazoles compound, it is a common compound, a new synthetic route is introduced below. 288-36-8
To a mixture of (2-iodophenyl)methanol [5159-41-1] (1.50 g, 6.41 mmol), 1 H-1 ,2,3-triazole (0.797 g, 11.54 mmol), trans-N, N’-dimethylcyclohexane-l ^-diamine [68737-65-5] (0.091 g, 0.641 mmol) and Cs2C03 (3.76 g, 1 1.54 mmol) in DMF (15 mL), Cul (0.61 g, 3.20 mmol) was added and the reaction mixture was stirred for 20 min at 120C and 15 min at 160C in the microwave. The reaction mixture was cooled to rt and filtered to remove the solids. The filtrate was concentrated under reduced pressure. The residue was purified by flash-column chromatography over silicagel (eluent: gradient 10%-100% ethyl acetate/heptane) to yield the title compound (1.46 g, 64%). [1H NMR (400 MHz, DMSO-cfe) USD ppm 8.10 (s, 2 H), 7.74 (d, J=7.53 Hz, 1 H), 7.61 (dd, J=8.03, 1.25 Hz, 1 H), 7.52 (td, J=7.53, 1.25 Hz, 1 H), 7.44 (m, 1 H), 5.26 (t, J=5.40 Hz, 1 H), 4.59 (d, J=5.02 Hz, 2 H); LCMS RtA = 0.68, [M+H]+ = 176.1].
The synthetic route of 288-36-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; NOVARTIS AG; BADIGER, Sangamesh; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; COTESTA, Simona; HINRICHS, Juergen Hans-Hermann; OFNER, Silvio; PANDIT, Chetan; WAGNER, Juergen; WO2011/76747; (2011); A1;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics