Reference of 4922-98-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4922-98-9, name is 5-Phenyl-1H-1,2,4-triazol-3-amine belongs to triazoles compound, it is a common compound, a new synthetic route is introduced below.
General procedure: Initially, amidoguanidines (7) were prepared via the reaction of substituted benzoyl chloride (5) (10 mmol) and aminoguanidine hydrochloride (6) (20 mmol). The obtained intermediates (7) were then treated with microwave irradiation power (100 W) for 8-15 min in water to generate 5-amino-1,2,4-triazoles (8) [18] . Subsequently, 5-amino-1,2,4-triazoles (8) (3 mmol) were reacted with ethoxycarbonyl isothiocyanate (3.3 mmol) in anhydrous DMF (4 ml) at room temperature, leading to formation of thiourea derivatives (9).
The synthetic route of 5-Phenyl-1H-1,2,4-triazol-3-amine has been constantly updated, and we look forward to future research findings.
Reference:
Article; Bera, Hriday; Lee, Min Huey; Sun, Lingyi; Dolzhenko, Anton V.; Chui, Wai Keung; Bioorganic Chemistry; vol. 50; (2013); p. 34 – 40;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics