Electric Literature of 584-13-4, A common heterocyclic compound, 584-13-4, name is 4H-1,2,4-Triazol-4-amine, molecular formula is C2H4N4, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
4.41 g (0.0525 mol) of 4-amino-4H-1,2,4-triazole and 11.26 g (99.28%, 0.05 mol) of 2-chloro-1-(2,4-dichlorophenyl)ethanone Place in a 250 ml three-necked flask and stir with 100 ml of isopropanol.Heating under reflux for 4 hours; the product crystallized at the reflux temperature,The reaction mixture was cooled, filtered and washed with isopropyl alcohol.After drying, the product was 11.073g (72%).Mp. 214-215C;
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Qilu Normal College; Liu Zhongqiang; (17 pag.)CN108929207; (2018); A;,
1,2,3-Triazole – Wikipedia,
Triazoles – an overview | ScienceDirect Topics